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New 'magnetic yeast' marks step toward harnessing Nature's magnetic capabilities
Date:2/28/2012

lates with magnetism by instructing the production of a critical protein that can dial up magnetism. They then enhanced the magnetic sensitivity even further through interaction with a second protein that regulates cell metabolism. Since the same metabolic protein functions similarly in cells ranging from simple yeast to more advancedeven humancells, the new method could potentially be applied to a much wider range of organisms.

Silver notes that in an industrial setting, magnetization could be extremely helpful as a means of targeting and isolating specific cells. Contaminated cells could be pulled out and disposed of during the processing of biological materials, and cells that are critical to a certain manufacturing process could be isolated and put to use. Magnetic cells could also be used to interact with non-living machinery. For example, magnetism could be used in tissue engineering to guide cells to layer themselves on a scaffold in a specific way. New therapies might one day be created in which cells are engineered to respond to a magnetic field by growing or healing, and implanted magnetic stem cells might one day be tracked with magnetic resonance imaging.

"This work shows how design principles from one type of cell can be harnessed using synthetic biology to transfer novel functionalities to another, which is a core approach driving the field of biologically inspired engineering," said Wyss Institute Founding Director Donald Ingber, M.D. Ph.D. Ingber is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Children's Hospital Boston, and Professor of Bioengineering at Harvard's School of Engineering and Applied Sciences. "The ability to control cells magnetically will also synergize with many other technologies in the pipeline at the Wyss Institute that rely on use of magnetic fields to control cell functions remotely, or to isolate rare cells from biological fluids."


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Contact: Twig Mowatt
twig.mowatt@wyss.harvard.edu
617-432-1547
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert

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