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New life sciences R&D model based on real-time learning and data-sharing needed to sustain innovation
Date:6/18/2012

e of low interest rates to raise large sums of debt. Importantly, capital raised by the rest of the industry (innovation capital) remained largely unchanged from the previous four years at US$16.8 billion. IPO buyers remained selective, with only 16 IPOs and aggregate proceeds of US$857 million, compared to US$1.3 billion in 2010.
  • M&As up, but big pharma largely absent:  Mergers and acquisitions involving European or US biotechs increased from 49 deals in 2010 to 57 deals in 2011. However, big pharma was the buyer in only 7 of these 57 deals, a potentially troubling trend given pharma's critical role in supporting biotech innovation.
    Ernst & Young estimates that the "firepower" of the top 28 drug companies to support biotech innovation declined by 30% between 2006 and 2011 — a situation that is not expected to improve with more patent expiries and investor pressure ahead.
  • A new model for industry R&D The report finds that drug R&D needs a new approach that is iterative, fast, adaptive, cost-efficient and open. The report propose such a new model, the holistic open learning network (HOLNet). These networks of diverse entities — drug firms, providers, patient groups, social media networks, data analytic firms and more — would pool vast amounts of data, share real-time insights from across the health care ecosystem, and adapt rapidly.  HOLNets would build on existing trends and, critically, connect information from across the value chain and cycle of care. This approach could:

  • Encourage data sharing in precompetitive spaces (e.g., genetic data from patients, claims data from payers, outcomes data from providers' Electronic Health Record systems, data on failed clinical trials from life sciences companies and insights from disease foundations)
  • Create uniform standards for data that will enable it to be combined and studied holistically
  • Enable engagement with regulators o
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  • SOURCE Ernst & Young
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