Navigation Links
New lab-on-a-chip technique developed at U of T
Date:10/9/2009

Scientists at the University of Toronto have developed a new "lab-on-a-chip" technique that analyses tiny samples of blood and breast tissue to identify women at risk of breast cancer much more quickly than ever before.

"The concentration of the hormone estrogen and its metabolites the products of metabolized estrogen in breast tissue are known to be significantly increased in breast cancer patients compared to healthy women, and is therefore believed to increase the risk of breast cancer. Despite this, breast estrogen levels in women at risk are not routinely measured because conventional techniques require large tissue samples obtained through invasive biopsies," says Dr. Noha Mousa, a Canadian Institute of Health Research fellow at Samuel Lunenfeld Research Institute and a clinical fellow in the Department of Obstetrics and Gynecology at the University of Toronto.

In response to this challenge, an interdisciplinary group of U of T scientists have used a new technology called digital microfluidics where instead of moving electrons across tiny wires, minute droplets of fluid are manipulated electrically on the surface of a microchip. Because these devices can be used to integrate multiple different laboratory functions, this type of technology is sometimes called a "lab-on-a-chip."

"We applied this technique for the first time to analyze hormones in tiny clinical samples we looked at blood, serum and breast cancer tissue," says Aaron Wheeler, director of the Wheeler Microfludics lab in the Department of Chemistry. "We developed methods to move droplets of several different kinds of reagents a substance consumed during a chemical reaction to extract hormones and purify them all on a device that can fit into the palm of a hand."

"The new methods we've developed may someday facilitate routine screening of clinical samples for analysis of hormones. This may be useful in many applications, including screening for risk of d
'/>"/>

Contact: Christine Elias
christine.elias@utoronto.ca
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology technology :

1. A New Era in the Application of Lab-on-a-Chip to Rapid Point-of-Care Diagnosis
2. Tiny lab-on-a-chip detects pollutants, disease and biological weapons
3. Leading Cardiovascular Surgeons Gather from Around the World to Share Ross Procedure Survival Data, Techniques at 2nd Annual Summit
4. Graphitic memory techniques advance at Rice
5. Single-molecule technique captures calcium sensor calmodulin in action
6. New MRI technique could mean fewer breast biopsies in high-risk women
7. New statistical technique improves precision of nanotechnology data
8. Five Cord Blood Transplant Centers in Catalonia and Valencia Join a Study to Test a New Technique to Treat Leukemia and Lymphoma
9. Secret of sandcastle construction could help revive ancient building technique, researchers say
10. Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting
11. Gender-Selection Technique Embraced for Hopeful Parents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... January 15, 2014 AudioNotch is the ... therapy for the treatment of tinnitus. Patients listen to ... and over a period of weeks to months, their tinnitus ... in two forms: Notched Music and Notched White Noise. Now, ...
(Date:1/14/2014)... 14, 2014  3D Communications, a leading provider of strategic communications services ... media events in the United States and ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as Associate ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management ... Product Strategy. In this role, Michelle will work with current ... in the development of iLab products. Her main goal will ... to the scientific community by offering the most advanced, user-friendly, ...
(Date:1/14/2014)... and Cardiff, UK (PRWEB) January 13, 2014 ... development leader with more than 20 years in the ... optics and photonics . Hainsey will serve as the ... to have Dr. Hainsey join SPIE as our Technology ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... to Membership , , , COLD SPRING HARBOR, ... year agreement with Amerinet Inc. to offer the AccuVein AV300, ... members. The AccuVein AV300 projects a pattern of light ... healthcare professional locate veins for blood draw (venipuncture), IV starts ...
... , NEW YORK, June 8 Keryx Biopharmaceuticals, Inc. ... the Phase 2 study of Zerenex (ferric citrate) for ... in patients with end-stage renal disease (ESRD) on thrice ... clinical trial, which enrolled 55 patients. The primary objective ...
... , DUROS(R) continuous delivery of exenatide produces impressive reductions ... 28-day treatment , , NEW ORLEANS, June 8 ... first clinical study of ITCA 650 (DUROS(R) continuous delivery ... as a late-breaker at the Annual Conference of the ...
Cached Biology Technology:AccuVein Inks National Three-Year Group Purchasing Deal With Amerinet 2Keryx Biopharmaceuticals Reports Positive Phase 2 Study Results of Zerenex (Ferric Citrate) for the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients 2Keryx Biopharmaceuticals Reports Positive Phase 2 Study Results of Zerenex (Ferric Citrate) for the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients 3Keryx Biopharmaceuticals Reports Positive Phase 2 Study Results of Zerenex (Ferric Citrate) for the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients 4Keryx Biopharmaceuticals Reports Positive Phase 2 Study Results of Zerenex (Ferric Citrate) for the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients 5Intarcia Therapeutics, Inc. Presents ITCA 650 Phase 1b Study Results as a Late-Breaker at the American Diabetes Association 69th Scientific Sessions 2Intarcia Therapeutics, Inc. Presents ITCA 650 Phase 1b Study Results as a Late-Breaker at the American Diabetes Association 69th Scientific Sessions 3Intarcia Therapeutics, Inc. Presents ITCA 650 Phase 1b Study Results as a Late-Breaker at the American Diabetes Association 69th Scientific Sessions 4
(Date:4/23/2014)... German . Man ... difference between sexes depends on one single element of the genome: ... two sexual chromosomes are X and Y, whereas women have two ... morphological and physiological differences between males and females. , But this ... the X and Y were identical, until the Y started to ...
(Date:4/23/2014)... Huntington,s disease, most in their mid-thirties and forties, ... behavioral decline within two decades. "Mutant" protein clusters, ... disease, have been the primary focus of therapies ... new research from Prof. Gerardo Lederkremer and Dr. ... Cell Research and Immunology, in collaboration with Prof. ...
(Date:4/23/2014)... (Apr. 23 2014) A team of ... cells (hNSCs) into the brains of nonhuman primates ... and 24 months found that the hNSCs had ... not cause tumors. , The study will be ... Transplantation but is currently freely available on-line ...
Breaking Biology News(10 mins):Male or female? 2Male or female? 3On the defensive 2On the defensive 3Study finds long-term survival of human neural stem cells transplanted into primate brain 2
... MDDouglas E. Koshland, staff scientist at Carnegie,s Department of ... the National Academy of Sciences (NAS) for his excellence ... one of the highest honors given to a scientist ... inducted into the academy next April during its 148th ...
... This press release is available in French . ... of the most deadly parasitic diseases in the world. It affects ... America alone it kills 50 000 people each year. A reliable ... but until now, this has been next to impossible. Dr. Momar ...
... internationally renowned plant cell biologist at the University of California, ... of Sciences ( NAS ) for his excellence in original ... of the highest honors given to a scientist or engineer ... academy next April during its 148th annual meeting in Washington, ...
Cached Biology News:Carnegie's Doug Koshland elected to National Academy of Sciences 2Major breakthrough in the diagnosis of parasitic diseases 2UC Riverside plant cell biologist receives top scientific honor 2UC Riverside plant cell biologist receives top scientific honor 3
Fingerprinting II cluster analysis is an optional module that adds dendrogram and phylogenetic tree construction, cluster and group significance, and congruence of techniques functions to the Fingerp...
Fingerprinting II Informatix optional matrix types module, is an optional module that adds external similarity and distance matrix functions to the Fingerprinting II Informatix software package....
... Lines ,High Quality, Functionally-Validated, Ion Channel Cell ... for having a critical role in nerve ... key function in pain, CNS and the ... been investigated in therapeutic areas, such as ...
... tissue microarrays are derived from frozen embedded ... quality control procedures to ensure the highest ... assembled in one block, sectioned at a ... coated slides. Sections are large (3-5 mm ...
Biology Products: