Navigation Links
New insight into dementia pathophysiology
Date:11/17/2010

Frontotemporal lobar degeneration (FTLD) refers to a group of disorders associated with degeneration of the frontal and temporal lobes of the brain. Symptoms include dementia, aphasia, and semantic disorders. Mutation of the gene for PGRN is associated with the most common form of FTLD, which is also characterized by inclusions of TDP-43 protein in the brain. Abnormal accumulation of TDP-43 has also been linked with amyotrophic lateral sclerosis (ALS).

While it is clear that a reduction in PGRN is causative for FTLD-TDP, the underlying mechanism is unknown. "Elucidation of PGRN action and the control of PGRN levels may have broad relevance for both FTLD and ALS," explains senior study author, Dr. Stephen M. Strittmatter from Yale University School of Medicine. "In order to advance the understanding of PGRN biology, we searched for cell surface binding sites that interact with PGRN."

Dr. Strittmatter and colleagues identified Sortilin as a key PGRN binding site on the surface of cortical neurons. In the stressed nervous system, PGRN was not expressed in neurons, but in nearby glial cells. Sortilin rapidly transferred PGRN inside of the neurons and delivered it to lysosomes, cellular structures that degrade proteins. Mice that did not express Sortilin exhibited high levels of extracellular PGRN. Importantly, mice with a PGRN deficiency similar to that seen in FLTD-TDP, were fully normalized with regards to PGRN levels when Sortilin was deleted.

Taken together, the findings implicate Sortilin-mediated PGRN endocytosis in FTLD-TDP pathophysiology and identify Sortilin binding as a potential therapeutic site to alter PGRN pathology. However, the authors are careful to caution that additional studies elucidating the connection between PGRN, Sortilin, and TDP-43 are needed. "Future functional studies of Sortilin in PGRN biology will require development of robust rodent models for PGRN-dependent neurodegeneration," says Dr. Strittmatter. "Nev
'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Protein Research Marketing Insights
2. BioTrends Releases TreatmentTrends(TM): Nephrology and Renal Dietitians, Two Syndicated Reports Providing Continuing Insight into the Management of Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism
3. Posit Science(R) Corporation Announces the Release of InSight(TM) 1.1
4. European Nephrologists Share Insights on the Management of Renal Anemia and Hyperphosphatemia in Latest BioTrends Report
5. BioTrends Releases TreatmentTrends(TM): US Nephrology, an Ongoing Syndicated Publication Providing Insight into Physician Perceptions and Management of Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism
6. Jatropha Sector Reality Check: Still Viable In Volatile Times? Upcoming Webcast Shares Latest Insights
7. Museomics yields new insights into extinct Tasmanian tiger
8. New Study Shares Insights for Competitive Intelligence Policies, Ethics and Data Collection
9. ExL Pharma Presents The Pharmaceutical Managed Markets Insight & Marketing for the Pharmaceutical Industry Conference
10. Stephen H. Friend, MD, PhD to Keynote at Defined Healths 9th Annual Therapeutic Insight Conference
11. PAREXEL Experts to Present Leading Insights at Drug Information Association 21st Annual Euromeeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... 2014 According to Jeff Howell, Partner ... ITRA Global, new development in Downtown Toronto is expanding ... approving another 755 storeys of new development last week ... will be dominating the Toronto skyline for the foreseeable ... unquenchable thirst for new development. , As the Toronto ...
(Date:9/16/2014)... RENU 28, the world's first and only skin ... purchase in Australia and New Zealand in mid-August . , ... The tour will make stops in Brisbane on September 16, ... Sydney on the 20th, and Melbourne on the 22nd. , ... and to educate people about the new product and business ...
(Date:9/15/2014)... phase transitionsthink solid, liquid, and gasbut much ... drops. If phase transitions occur at the ... subtle fluctuations can dramatically transform a material. ... of Energy,s Brookhaven National Laboratory and Stony ... of absolute zero to isolate and probe ...
(Date:9/15/2014)... Sept. 15, 2014   Global Science & ... scientific products and services for satellite and weather ... for Integrated Services (OASIS) from the General Services ... selected to provide the government best-value solutions for ... (SB) category in Pool 4. The OASIS SB ...
Breaking Biology Technology:ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 2ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 3Global Wellness Company Hosts ASEA Australia Tour September 16-22 2Elusive quantum transformations found near absolute zero 2Elusive quantum transformations found near absolute zero 3Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 3
... organizations see security and compliance as their top issues, they ... There is a big secret that few executives know about ... issue. It goes beyond knowing virus scans and firewalls. Security ... strategy and not a low-level function. , ,In several semesters ...
... trend away from IPOs and the progress of six regional ... Fund I annual meeting, held at the Wisconsin Athletic Club. ... Mason Wells met in Milwaukee to hear a speech ... Association , and listen to updates from six firms that ...
... Bone Care International Inc. announced on Wednesday that the ... ,Genzyme and Bone Care have signed a definitive agreement for ... transaction valued at $33.00 per fully diluted share. ... Care's shareholders at a meeting on June 30, and other ...
Cached Biology Technology:To find solid security candidates, look beyond tech certificates 2To find solid security candidates, look beyond tech certificates 3To find solid security candidates, look beyond tech certificates 4VC trends, company progress discussed at Mason Wells portfolio meeting 2VC trends, company progress discussed at Mason Wells portfolio meeting 3VC trends, company progress discussed at Mason Wells portfolio meeting 4
(Date:9/15/2014)... skin and gut microbes influence processes from digestion to ... the most biodiverse terrestrial ecosystems on the planet, more ... in the tropics. Smithsonian scientists and colleagues working on ... from a single tree were home to more than ... 57 tree species contained more than 7,000 different kinds. ...
(Date:9/15/2014)... (September 15, 2014) The so-called central dogma ... proteinhas long provided a simplified explanation for how ... organisms. , In reality, of course, the ... first articulated nearly 60 years ago by Nobel ... structure. For one, there are multiple types of ...
(Date:9/15/2014)... A published study indicates that lowland tapir populations may ... on hunting. Researchers from the Office National de ... Guiana and San Diego Zoo Global reviewed data retrieved ... the last four years and compared this data to ... were placed on hunting tapirs in French Guiana," said ...
Breaking Biology News(10 mins):Smithsonian scientists discover tropical tree microbiome in Panama 2Scientists discover RNA modifications in some unexpected places 2
... As governments prepare to gather at the United ... and 20, a new report published by a group ... evidence that a combined approach to tackling poverty and ... education, and nutrition/food securityachieves better results for the world,s ...
... which extends to include the formal scientific naming of all ... in the procedure scientists need to follow when they describe ... ,International Code of Nomenclature for algae, fungi and plants, are ... article published in BioMed Central,s open access journal BMC ...
... for Research on Aging (Novato, CA) and Biotica Technology ... investigate polyketides in diseases of aging. Building on observations ... & Kennedy; Nature 2009), the collaborators will ... range of age-related disease models to identify novel therapeutics. ...
Cached Biology News:Report showcases success of integrated development approaches 2Report showcases success of integrated development approaches 3Bringing botany into the 21st Century 2Buck Institute and Biotica to investigate polyketides in extension of healthy lifespan 2
... Polymorphic DNA Technologies offers a comprehensive SNP ... for SNP discovery by performing a service ... amplification, DNA sequencing and data analysis. ... Polymorphic uses the gold standard in DNA ...
... Sub-Cell Model 192 and PowerPac basic power supply ... nucleic acids in agarose gels. This Model 192 ... 15 cm UV-transparent gel tray with fluorescent ruler, ... supply, 100-120 and 220-240 V, provides output of ...
... you reduce the chance of error. Thats ... Developed using Beckman Coulters extensive experience in ... technology, the CEQ 8000 is a fully ... fills the capillary array with a patented ...
The optional fixed lens, 105 mm, is for use with the VersaDoc imaging systems for imaging small samples at high resolution....
Biology Products: