Navigation Links
New insight in nerve cell communication
Date:12/22/2009

Communication between nerve cells is vital for our bodies to function. Part of this communication happens through vesicles containing signalling molecules called neurotransmitters. The vesicle fuses with the nerve cell membrane; the neurotransmitters are released and quickly recorded by the next nerve cell. It is crucial that new vesicles constantly are produced for the nerve cell communication continuously to take place. If parts of this communication do not work, it leads to nerve pain like phantom pain following amputation.

New discoveries on a nanoscale

- In patients with nerve pain, part of the pathological picture is a defect in a protein domain we call BAR. We have studied how BAR binds to small membrane vesicles of different size. We expect that the new knowledge can be used to combat nerve pain in the future, explains Associate Professor Dimitrios Stamou, Bio-Nanotechnology Laboratory, Nano-Science Center and the Department of Neuroscience and Pharmacology. Dimitrios Stamou has led the work.

- We have used nanotechnology techniques, which give us the unique opportunity to study the binding of proteins to individual vesicles. Earlier studies have been performed in solutions where you measure a large number of vesicles and proteins at a time. This gives an average value of binding and "masks out" a large number of important information that we can retrieve by measurements on single vesicles, says Dimitrios Stamou.

Error in communication

More and more studies this study included, show that the curvature of the membrane is absolutely central to the binding of proteins to cell membranes the greater the curvature, the greater the binding. This also applies to nerve cells in the brain. It therefore provides an important insight for the overall understanding of how nerve cells communicate with each other and for treating diseases where the communication has failed.

- To our great surprise we find that BAR binds to the membrane vesicles via small cracks in the vesicle membrane. We had expected that BAR bound to the small round membrane vesicles both because of its banana shaped structure, which fits with the shape of the vesicle, and by means of an attraction between "the banana's" positive surface and vesicle's negative surface. But instead, it is the hydrophobic part of BAR that is involved in binding, explains Dimitrios Stamou.


'/>"/>

Contact: Dimitrios Stamou
stamou@nano.ku.dk
454-116-0468
University of Copenhagen
Source:Eurekalert  

Related biology technology :

1. Dental Implant Market Insights Webinar
2. InSightec Resumes Clinical Trials for Non-Invasive Treatment of Brain Tumors
3. Medivation Selected as Founding Member of New NASDAQ(R) NeuroInsights(R) Neurotech Index
4. Arena Pharmaceuticals Selected to Join New NASDAQ NeuroInsights Neurotech Index
5. New Scrip Report Provides Strategic Insight on the Burgeoning Biosimilars Market
6. New insights into the fate of anti-parasitics in manure and manured soils
7. PAREXEL to Present Leading Insights Regarding Key Industry Topics at 20th Annual Drug Information Association EuroMeeting
8. Apieron, Inc. Announces FDA Clearance of the Insight(TM) eNO System to Assist Physicians with Patient Asthma Management
9. PAREXEL Experts to Offer Insights Into Outsourcing Best Practices at 17th Annual Partnerships with CROs Conference
10. Pharmaceuticals & Biotechs to Share Insights for Developing Leaders in a Fast-Paced, Competitive Industry
11. New insights into cellular reprogramming revealed by genomic analysis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insight in nerve cell communication
(Date:6/28/2017)... 2017 Spectrecology LLC has announced a 4 ... and research dollars. The program is designed to help ... spectroscopy and photonics equipment despite current funding challenges.  The ... Innovations in Spectroscopy Grants – Discounts ... used for the classroom or research. ...
(Date:6/28/2017)... (PRWEB) , ... June 28, ... ... Siemens’ STAR-CCM+® software for multiphysics computational fluid dynamics (CFD) simulation and analysis ... and optimization. STAR-CCM+ version 12.04 introduces Design Manager, allowing users to easily ...
(Date:6/27/2017)... ... June 27, 2017 , ... Biodex Medical Systems, Inc. announces ... in one device. This assistive aid lifts patients safely from a seated to a ... lift mechanics. The Mobility Assist is the latest in a line of Biodex products ...
(Date:6/26/2017)... ... ... Third Wave Bioactives, LLC announces the addition of Brett Thompson. Brett joins ... and ensuring quality customer experience. , Brett brings to Third Wave Bioactives ... and sales roles. “Brett’s background working with customers and eye for market opportunities make ...
Breaking Biology Technology:
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
(Date:4/6/2017)... -- Forecasts by Product Type (EAC), Biometrics, ... (Transportation & Logistics, Government & Public Sector, Utilities / ... Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality ... looking for a definitive report on the $27.9bn Access ... ...
Breaking Biology News(10 mins):