Navigation Links
New insight in nerve cell communication
Date:12/22/2009

Communication between nerve cells is vital for our bodies to function. Part of this communication happens through vesicles containing signalling molecules called neurotransmitters. The vesicle fuses with the nerve cell membrane; the neurotransmitters are released and quickly recorded by the next nerve cell. It is crucial that new vesicles constantly are produced for the nerve cell communication continuously to take place. If parts of this communication do not work, it leads to nerve pain like phantom pain following amputation.

New discoveries on a nanoscale

- In patients with nerve pain, part of the pathological picture is a defect in a protein domain we call BAR. We have studied how BAR binds to small membrane vesicles of different size. We expect that the new knowledge can be used to combat nerve pain in the future, explains Associate Professor Dimitrios Stamou, Bio-Nanotechnology Laboratory, Nano-Science Center and the Department of Neuroscience and Pharmacology. Dimitrios Stamou has led the work.

- We have used nanotechnology techniques, which give us the unique opportunity to study the binding of proteins to individual vesicles. Earlier studies have been performed in solutions where you measure a large number of vesicles and proteins at a time. This gives an average value of binding and "masks out" a large number of important information that we can retrieve by measurements on single vesicles, says Dimitrios Stamou.

Error in communication

More and more studies this study included, show that the curvature of the membrane is absolutely central to the binding of proteins to cell membranes the greater the curvature, the greater the binding. This also applies to nerve cells in the brain. It therefore provides an important insight for the overall understanding of how nerve cells communicate with each other and for treating diseases where the communication has failed.

- To our great surpri
'/>"/>

Contact: Dimitrios Stamou
stamou@nano.ku.dk
454-116-0468
University of Copenhagen
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Dental Implant Market Insights Webinar
2. InSightec Resumes Clinical Trials for Non-Invasive Treatment of Brain Tumors
3. Medivation Selected as Founding Member of New NASDAQ(R) NeuroInsights(R) Neurotech Index
4. Arena Pharmaceuticals Selected to Join New NASDAQ NeuroInsights Neurotech Index
5. New Scrip Report Provides Strategic Insight on the Burgeoning Biosimilars Market
6. New insights into the fate of anti-parasitics in manure and manured soils
7. PAREXEL to Present Leading Insights Regarding Key Industry Topics at 20th Annual Drug Information Association EuroMeeting
8. Apieron, Inc. Announces FDA Clearance of the Insight(TM) eNO System to Assist Physicians with Patient Asthma Management
9. PAREXEL Experts to Offer Insights Into Outsourcing Best Practices at 17th Annual Partnerships with CROs Conference
10. Pharmaceuticals & Biotechs to Share Insights for Developing Leaders in a Fast-Paced, Competitive Industry
11. New insights into cellular reprogramming revealed by genomic analysis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insight in nerve cell communication
(Date:1/14/2014)... , Jan. 14, 2014 The largest ... research medicinal plants and therapeutic derivatives thereof has ... professionals, and researchers about the challenges of adulterated ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society for ...
(Date:1/14/2014)... 14, 2014 In recent years, growing ... methods in product development and promotion has led to ... mistrust, fueled by concerns about the insidious impact of ... of spectacular fines to the world’s biggest pharmas for ...
(Date:1/14/2014)... 14, 2014   Kinaxis ®, provider of RapidResponse ®, ... and operations planning ( S&OP ) service, is proud to ... which will be held at the Hilton San Diego Bayfront, ... customer Elisabeth Kaszas , Director of Supply Chain at ...
(Date:1/14/2014)... NY (PRWEB) January 14, 2014 During the ... now known as “The Doctor’s Plague.” In this time period, ... hands. This led, at times, to the death of vulnerable ... today don’t know that they may be unwittingly transmitting herpes ...
Breaking Biology Technology:World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... the only one completely confused by the Cingular merger with ... facts of the deal. Cingular Wireless acquires the assets and ... have 46 million customers, topping now No. 2 carrier Verizon ... keeps the rights to the AT&T Wireless brand and plans ...
... of the statewide Wisconsin business-plan contest this year ... survive the first round than they did during the inaugural ... initial abstracts of business ideas has passed, a panel of ... The survivors, who must write extended summaries for a further ...
... of Wisconsin-Milwaukee The director of the university's ... would leave for the University of Cincinnati in April. Professor ... feel valued, and that UW-Milwaukee does not have good ... , Menasha, Wis. Banta Corporation said it would ...
Cached Biology Technology:Cingular confusion 2Cingular confusion 3Coaching available for business-plan contest survivors 2
(Date:7/9/2014)... puzzle behind nature,s ability to split the water ... development of artificial photosynthesis for clean, green and ... collaboration of scientists led by researchers with the ... SLAC National Accelerator Laboratory. , Working at ... most powerful x-ray laser, the researchers were able ...
(Date:7/9/2014)... Guelph scientist that involved fitting bumblebees with tiny ... neonicotinoid pesticide hampers bees, ability to forage for ... professor in Guelph,s School of Environmental Sciences, and ... July 9 in the British Ecological Society,s journal ... how long-term pesticide exposure affects individual bees, day-to-day ...
(Date:7/9/2014)... With grilling season upon us, many backyard cooks are ... fatty hot dogs. But low fat can sometimes mean ... addressing the texture problem in low-fat wieners that are ... study was published in ACS, Journal of Agricultural ... colleagues note that hot-dog consumers have come to expect ...
Breaking Biology News(10 mins):Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3Bee foraging chronically impaired by pesticide exposure: Study 2
... ARBOR, Mich. Researchers at the University of ... techniques for head and neck cancer to avoid ... A new study shows these principles and techniques ... swallowing complications. The researchers applied highly conformal, ...
... a CD, reminded her son, Ryan, of his 4-H project when ... three beautiful squealing black and white piglets at the auction," she ... Lincoln Town Car, because we didn,t have a truck." Recordings ... him four times a day. They were part of a new ...
... The European Nucleotide Archive (ENA) is launched today, consolidating ... point to globally comprehensive DNA and RNA sequence information. ... Institute (EMBL-EBI), a part of European Molecular Biology Laboratory. ... previously unimaginable amounts of data being deposited in the ...
Cached Biology News:U-M study achieves reduced side effects in head and neck cancer treatment 2Can a mother's voice spur recovery from a coma? 2Can a mother's voice spur recovery from a coma? 3Can a mother's voice spur recovery from a coma? 4Can a mother's voice spur recovery from a coma? 5Enabling easy access to DNA sequence information 2