Navigation Links
New hydrolysis model promising tool in cellulosic biofuel studies
Date:7/26/2010

Scientists are working hard to develop the tools and find the organisms to break down the complex structure of plant cellulose into its component sugars the key step toward fermentation of those sugars into usable biofuel. This process needs to be simple and economically efficient before cellulosic biofuels can compete with fossil fuels for transportation energy use.

As with any exploration of systems that involve largely unknown processes, a mechanistic model can be an important first step in improved understanding. Researchers at the Energy Biosciences Institute's (EBI) laboratories on the University of California, Berkeley, campus have improved that step, bringing science closer than ever before to predicting the deconstruction activity of enzymes towards cellulose.

In a paper recently accepted by the journal Biotechnology and Bioengineering, four EBI scientists at UC Berkeley chemical engineering faculty members Doug Clark and Harvey Blanch, postdoctoral researcher Seth Levine and graduate student Jerome Fox detail their analysis that led to the most specific model to date of the enzymatic hydrolysis of cellulose.

"It's a first step in being able to have a detailed picture of what happens between cellulases (enzyme mixtures with complementary activities) and the substrate (cellulose)," said lead author Levine. Through this better understanding of the breakdown mechanisms, he said, more directed and rational approaches can be taken to engineer effective enzymes and improve the overall process of hydrolysis.

Much of the action happens at the surface of a substance like cellulose, the fibrous polysaccharide in the plant cell wall composed of hydrogen-bonded chains of the sugar glucose. Levine likens the surface to a "black box," where multiple shapes and unknown features of particles add to the complicated nature of the reactions there. Previous models relied on simple, sometimes overly broad assumptions and expla
'/>"/>

Contact: Ron Kolb
rrkolb@berkeley.edu
510-643-6255
University of California - Berkeley
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Campbell Alliance Sales Practice to Present at CBIs Leadership Summit on Evolving the Pharma Sales Model
2. Repligen Announces Publication of Positive Results with Proprietary HDAC Inhibitor in Huntingtons Disease Model
3. LifeModeler, Inc. Provides $400,000 Grant to InMotion Musculoskeletal Institute
4. Tengion Featured as Model of Innovation and Success at 35th Anniversary Celebration of the National Venture Capital Association
5. Pigs bred with cystic fibrosis provide model to mimic human disease
6. Researchers develop new model for cystic fibrosis
7. Samaritan Partners Forgetful Rat Model to Taconic to Commercialize
8. EntreMeds ENMD-2076 Demonstrates Tumor Regression in Human Colon Cancer Model
9. Antiangiogenic Role of 2ME2 Demonstrated in Rheumatoid Arthritis Models
10. Stem Cell Sciences Licenses Stem Cell Technology to Leading Provider of Genetically Modified Models for Pharmaceutical Research
11. Sigma-Aldrich Introduces MISSION(R) In VIVO QUALITY and iScale Oligos(TM) siRNA, a Superior Quality siRNA Designed for RNAi Research in Animal Models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... CA (PRWEB) October 30, 2014 ... today that they have manually curated public data source ... non profit customers. the data is now available ... curates and unifies public and internal data sources for ... and knowledge out of the data that becomes more ...
(Date:10/30/2014)... Grace Century portfolio project, Provia Laboratories , ... the Board, to the National Stem Cell Ethics Committee ... by the Ministry of Health on behalf of the Government ... More than a year after Bahamian Parliament passed the ... Christie said the government has completed the accompanying regulations and ...
(Date:10/30/2014)... that devastated a wide swath of Colorado last year ... and other infrastructure had been upgraded or modernized, according ... Denver. , "People need to understand the importance and ... of structural engineering at the CU Denver College of ... "There is an assumption that a bridge will stand ...
(Date:10/27/2014)... YORK , Oct. 27, 2014 Kalorama ... the recent Ebola concern in the United ... the virus.  The healthcare market researcher said the FDA,s Emergency ... in vitro diagnostic tests for the detection of the ... has proved useful.  Kalorama routinely assess the IVD industry ...
Breaking Biology Technology:Rancho BioSciences Manually Curated TCGA Data Sets Available 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3CU Denver study says upgrading infrastructure could reduce flood damage 2Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3
... Bill Gates , Co-Chair and Trustee of the Bill & Melinda ... mobile technologies to improve health outcomes in the developing world at ... The summit, organized by the Foundation for the National Institutes of ... the mHealth Alliance, will be held November 8-10 in ...
... ROCKVILLE, Md. , Aug. 2 Vanda Pharmaceuticals Inc. (Vanda) (Nasdaq: ... and commercialization of products for central nervous system disorders, today announced it will ... 2010 , before the market opens. A full text copy of the release ... , , ...
... 2 Tengion Inc. (Nasdaq: TNGN ) ... the position of Chief Financial Officer.  Mr. Davis comes to Tengion after ... to develop improved protein therapeutics. At its peak, Neose employed 200 individuals, ... , , ...
Cached Biology Technology:Bill Gates Named Keynote Speaker at the 2010 mHealth Summit 2Bill Gates Named Keynote Speaker at the 2010 mHealth Summit 3Bill Gates Named Keynote Speaker at the 2010 mHealth Summit 4Vanda Pharmaceuticals to Announce Second Quarter 2010 Financial Results on August 5, 2010 2Tengion Appoints A. Brian Davis Chief Financial Officer 2
(Date:10/29/2014)... who lose their hair as a consequence of chemotherapy ... improve the scalp cooling technology that prevents hair loss. ... being pioneered by global scalp cooling manufacturing company, Paxman ... biology department of the University of Huddersfield. , The ... who has a background in the pharmacology of cancer ...
(Date:10/29/2014)... their food, but they also need protection from its harmful ... of molecules in plants that shields them from sun damage. ... American Chemical Society , one team reports on the mechanics ... and colleagues at Purdue University note that the harsh ultraviolet ... to plant DNA and, as a result, hinder plant growth. ...
(Date:10/29/2014)... German . ... Peter Schlögelhofer at the Max F. Perutz Laboratories (MFPL) ... of Vienna dived into the process of meiosis in ... an inversion of the standard meiotic phases. The researchers ... Nature Communications . , Meiosis is the two-step series ...
Breaking Biology News(10 mins):New technology on the way to aid cancer suffers who lose their hair after chemotherapy 2Meiotic cell division 'the other way round' 2
... Aluminum salts, or alum, have been injected into billions of ... one knows, however, how they boost the immune response. In ... the National Academy of Sciences researchers at National Jewish ... that host DNA coats the alum adjuvant and induces two ...
... N.C. -- The cost of complying with tougher EPA air-quality ... toward natural gas for electricity generation, according to a new ... particulate matter, nitrogen oxide and mercury may make nearly two-thirds ... as plants powered by natural gas, the study finds. ...
... Engineering Professor Tim Bender and Post-Doctoral Fellow Benoit ... polymer synthesis could have implications for the manufacture ... and even medical implants, the researchers say. ... subphthalocyanine polymers by facile coupling to poly (acrylic ...
Cached Biology News:Vaccine adjuvant uses host DNA to boost pathogen recognition 2Vaccine adjuvant uses host DNA to boost pathogen recognition 3New emissions standards would fuel shift from coal to natural gas 2Accidental discovery may lead to improved polymers 2
... agarose is used for second-dimension SDS-PAGE ... in place in PROTEAN Plus cells. ... to allow monitoring of electrophoresis runs. ... agarose in 1x Tris, glycine, SDS, ...
... HV high-voltage power supply, with temperature probe, 100-120 ... 5,000 V, 500 mA, and 400 W. The ... between 0 and 90 degrees C during electrophoresis. ... Power cord and instructions are provided. Dimensions are ...
The stirbar is used in the buffer tank of the Trans-Blot Plus cell to maintain uniform conductivity and temperature during electrophoretic transfer. Dimensions are 3.5 x 0.5 in....
... cooling coil, Trans-Blot cell, provides ... high-intensity, and extended electrophoretic transfer ... Trans-Blot cell. Use of the ... to an external water recirculator, ...
Biology Products: