Navigation Links
New findings could overcome major stumbling blocks to tissue cryopreservation for medical care
Date:11/5/2013

Developing an efficient way to freeze and store living tissues could transform many aspects of medical care and research, but ice crystallization often occurs within cells during such cryopreservation procedures, leading to cell death. In the November 5 issue of the Biophysical Journal, a Cell Press publication, researchers report that they have gained new information about the processes that are responsible for promoting the freezing of cells within tissues. This knowledge may ultimately lead to novel approaches for preventing tissue injury during cryopreservation.

A long-standing obstacle to avoiding tissue damage during freezing is that when cells are joined together within tissues, individual cells are more likely to crystallize than if the cells are kept apart. "In tissues, ice crystals are thought to be able to grow through membrane channels called gap junctions, thus allowing ice to easily propagate from cell to cell," explains senior author Dr. Jens Karlsson, of the Department of Mechanical Engineering at Villanova University. "But the results of the present study indicate that the mechanism of tissue cryo-injury is much more complex than was previously thought."

Dr. Karlsson and his team monitored microscopic freezing events inside genetically modified cells and used mathematical models to show that gap junctions do not always provide the major pathway for the spreading of ice crystals between cells. They saw that cell-to-cell propagation of ice also occurred during freezing of tissue samples in which gap junction formation had been suppressed. The authors discovered that intercellular connectionsin which neighboring cell membranes are stitched together by rows of rivet-like structures known as tight junctionsalso play a significant role.

"By using high-speed video imaging, we found evidence that ice from outside the cells sometimes forms nanoscale branches, which can penetrate the barriers created by tight junction
'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. US Oncology Research Affiliated Physician to Present Findings From Innovative Clinical Trial at 2011 CTRC-AACR San Antonio Breast Cancer Symposium
2. 23andMe Presents Top Ten Most Interesting Genetic Findings of 2011
3. Live Press Briefing on Findings of Biomedical Industry CEO Survey
4. GeoVax Labs Presents New Findings on Potential HIV Vaccine at 2012 Conference on Retroviruses and Opportunistic Infections (CROI)
5. Expanded Findings for FirstMarks Completed Clinical Study for Predicting Near-Term (2-3 Years) MI
6. Profil Institute Continues to Publish New Findings in Metabolic Research
7. New Findings of Daily Consumption of Soy Isoflavones and Cacao-Flavonoids in Diabetes Type 2 Patients
8. Published Findings In Human Gene Therapy Methods Journal Demonstrate Cardiums New Catheter-Based Method Significantly Boosts Gene Delivery To The Heart
9. Findings could be used to engineer organs
10. ENDECE Neural to Present Findings at 2013 Biotech Showcase on NDC-1308 which Induces Remyelination of Demyelinated Axons
11. Fertility Associates of Memphis, World-Renowned Expert in Infertility, Presents Findings to European Conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New findings could overcome major stumbling blocks to tissue cryopreservation for medical care
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... series is designed to introduce cutting edge ... users and partners of platform upgrades. This ... benefits; empowering users in their quest to ... tools. , According to SoundConnect’s Marketing Manager, ...
(Date:12/24/2014)... Texas (PRWEB) December 23, 2014 ... methyl mercaptan such as its definition, classification, ... presents product specification, manufacturing process, and product ... technology and applications. The analysis also covers ... marketing channels, industry development trend and proposals. ...
(Date:12/24/2014)... 2014 Pipette.com announces their Holiday ... can submit their #HolidayInTheLab pictures for a chance to ... , For those struggling to think of a holiday ... in the Lab Contest provides the ideal holiday presents. ... to send pictures of their chemistree, holiday sweaters, as ...
(Date:12/24/2014)... , December 23, 2014 ... Algeria , out today and available for free download ... actors driving change and growth in the sector today. ... scored notable successes has been in developing a homegrown pharmaceutical ... percent local production still remains some way off. A cursory ...
Breaking Biology Technology:SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3
... thing with IT shops right now. It's the new magic ... word and the music swells. Then we'll go skipping off ... happy customers. Yes, I was touting partnership just last week ... hard work. Partnership is the right relationship answer only if ...
... announced Wednesday it has been awarded a contract ... management hardware for a U.S. Department of Energy ... million project will develop, manufacture and demonstrate a mine ... metal-hydride storage and refueling hardware. , ,The project was ...
... Left to right: Professor James Dumesic, graduate students Steven ... researcher Won Bae Kim. Source: UW-Madison. MADISON - ... technical barrier to the efficient operation of fuel cells. ... of Wisconsin-Madison have not only cleared that barrier - ...
Cached Biology Technology:Blooming partnerships 2Blooming partnerships 3Blooming partnerships 4Modine Manufacturing to contribute to DOE's fuel-cell vehicle 2UW engineers clear bottleneck in hydrogen production 2
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the ... APAC Region 2015-2019"  report to their offering. ... market is advances in technology. With continuous advances ... solutions to the latest standard that meets the ...
(Date:12/11/2014)... , Dec. 10, 2014  That blood pressure plays ... a while. Hypertension – the medical term for high blood ... early 1800s, and the inflatable cuff that,s used in measuring ... however, mean there,s nothing new about hypertension, its triggers and ... beliefs about the condition and the best ways to treat ...
(Date:12/10/2014)... 2014 You,ve been here before: you desperately need ... your password, site key or the answer to your secret ... teacher? Today, Hoyos Labs , a ... will finally put an end to the frustration that comes ... . 1U leverages a user,s smartphone to acquire his or ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... 6, 2011 Ceelox, Inc. (OTCBB: CELO) announced today ... which operates on computers running the Windows 7 Operating ... their authentication approach to leverage the recent capability of ... (WBF) provides support for fingerprint biometric devices through a ...
... an alternative to drugs for the prevention of esophageal ... Annual Meeting 2011, held here April 2-6. ... eating strawberries is safe and easy to consume. In ... histological grade of precancerous lesions and reduce cancer-related molecular ...
... That,s the agonizing choice some birds face, according to ... by Guelph researchers discovered that for some male birds traveling ... attracting a female when they return home. Alice Boyle, a ... Chris Guglielmo, a biologist at the University of Western Ontario, ...
Cached Biology News:Ceelox Offers Beta Release of Ceelox ID 7 for Personal Computers 2Strawberries may slow precancerous growth in esophagus 2Birds must choose between mating, migrating, study finds 2
Mouse monoclonal [M2II-12] to MRP2 ( Abpromise for all tested applications). entrezGeneID: 1244 SwissProtID: Q92887...
Mouse monoclonal antibody to ANAPC2 - anaphase promoting complex subunit 2...
... The MAX POWER 500V Programmable ... operate instruments which can handle virtually ... to high current blotting. It is ... text displays. The MAX POWER Programmable ...
The Programmable MP-3500P-F Power Supply can be applied for any Microfluidic application....
Biology Products: