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New findings by UCR scientists hold big promise for fight against mosquito-borne diseases
Date:6/1/2011

s, effectively "blinding" the mosquitoes and disabling their carbon dioxide detection machinery for several minutes.

"These chemicals offer powerful advantages as potential tools for reducing mosquito-human contact, and can lead to the development of new generations of insect repellents and lures," said Ray, who led the study. "The identification of such odor molecules which can work even at low concentrations, and are therefore economical could be enormously effective in compromising the ability of mosquitoes to seek humans, thus helping control the spread of mosquito-borne diseases."

Female mosquitoes spread disease by first obtaining a blood meal from an infected person and subsequently finding an uninfected person to bite. Extremely sensitive to minute changes in carbon dioxide concentrations, they can sense carbon dioxide in our breath from long distances. Upon encountering a carbon dioxide plume, the mosquitoes orient and fly upwind, arriving eventually near us.

Most mosquito-trapping devices also use carbon dioxide to attract mosquitoes. But these devices tend to be expensive and bulky, and suffer from the usual difficulties associated with supplying carbon dioxide via gas cylinders, dry ice or propane combustion.

"Odor molecules that mimic carbon dioxide activity, on the other hand, can lead to the development of small and inexpensive lures to trap mosquitoes a great benefit, especially to developing countries," Ray said. "These highly portable, convenient and easily replenishable lures can be used wherever mosquitoes are a menace."

In the case of the "blinder" class of molecules, Ray's group found that even a brief exposure to these odor molecules (presented in a blend of four odors: 2.3-butanedione, 1-hexanol, 1-butanal and 1-pentanal) activated the carbon dioxide-sensitive neurons in mosquitoes for at least five and a half minutes, and evoked such a strong and prolonged response in the neurons
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Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert  

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New findings by UCR scientists hold big promise for fight against mosquito-borne diseases
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