Navigation Links
New discovery reveals fate of nanoparticles in human cells
Date:9/22/2009

Scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) have uncovered what happens to biomimetic nanoparticles when they enter human cells. They found that the important proteins that make up the outer layer of these nanoparticles are degraded by an enzyme called cathepsin L. Scientists now have to take this phenomenon into account and overcome this process to ensure the exciting field of nanomedicine can progress. The research is published today (22 September) in ACS Nano.

Dr Raphal Lvy, a BBSRC David Phillips Fellow at the University of Liverpool and lead researcher on the project said: "We've known for some time that nanoparticles are taken into cells and there have been experiments done to establish their final destinations, but we didn't know until now what state they are in by the time they get there."

In most biological applications, nanoparticles are coated with a layer of molecules, often proteins, which determine the use of nanoparticles when they enter cells. The researchers have confirmed, in a wide range of cells, that nanoparticles are taken into a region called the endosome, where this essential coating is degraded by cathepsin L.

Dr Violaine Se, also a BBSRC David Phillips Fellow at the University of Liverpool, and joint corresponding author, added: "One of the promising applications of nanoparticles in medicine is to use them as a method to deliver therapeutic protein molecules inside cells. For these biological therapies to be effective the proteins have to be maintained with high integrity and unfortunately we have seen this compromised by the degrading action of cathepsin L."

The design of any intracellular nanodevice must now take into account the possibility of cathepsin L degradation and either bypass the endosome area all together or have some built-in inhibition of the enzyme.

Dr Lvy continued: "The methods we have developed will help with this as we
'/>"/>

Contact: Nancy Mendoza
press.office@bbsrc.ac.uk
44-179-341-3355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Antigen Discovery, Inc. Awarded Grant for Chlamydia Vaccine Development
2. CELLECTA, INC. to Develop New Approach for Cancer Gene Discovery in Partnership with Roswell Park Cancer Institute and Health Research, Inc.
3. StoredIQ Shares Expertise at IQPCs eDiscovery Pharma, Biotech and Medical Device Conference
4. Alzheimers Drug Discovery Foundation and the Lewy Body Dementia Association Invite Scientists to Apply for LBD Grant Award Program
5. PTC Therapeutics Announces Celgene Exercised Option to Drug Discovery Collaboration
6. PTC Therapeutics Announces Drug Discovery Collaboration With Roche
7. ChemBridge Corporation and Collaborative Drug Discovery Announce Strategic Collaboration to Provide Diverse Chemical Libraries Together With Researchers Own Private Data
8. Alzheimers Drug Discovery Foundation Hosts 10th International Conference on Alzheimers Drug Discovery - September 14-15
9. Rib-X Pharmaceuticals Antibiotic Drug Discovery Platform Discovers Novel Compounds with Activity Against Key Multiple Drug Resistant Gram-negative Bacteria
10. Discovery of natural odors could help develop mosquito repellents
11. PharmatrophiX, Initially Funded by the Alzheimers Drug Discovery Foundation, Announces Exclusive Global Collaboration with Elan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... July 30, 2015 Ascendis Pharma A/S ... applies its innovative TransCon technology to address significant ... from a six-month Phase 2 study to evaluate ... Hormone in 53 treatment-naïve, pre-pubertal children with growth ... extremely pleased with the top-line results from our ...
(Date:7/30/2015)... , July 30, 2015  Discovery Laboratories, Inc. ... has received the second $1.0M tranche under a ... (SBIR) grant valued at up to $3.0 million ... KL4 surfactant as a potential medical countermeasure to ... Labs was awarded an initial $1.0 million under ...
(Date:7/30/2015)... ... 2015 , ... GEA's Pony™ NS2006L is a ... to 1500 bar. The sanitary design gauge of the NS2006L is well suited ... Pony™ NS2006L homogenizer is an ideal solution for the processing of nanoparticles, ...
(Date:7/29/2015)... -- Sanofi, un leader mondial et ... le premier semestre 2015. Le Directeur Général ... Visionner l,interview vidéo et lire la transcription :  ... sommaire de l,interview :  - Résultats ... - Diabète - Praluent ...
Breaking Biology Technology:Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2
... Global consultant Tom Koulopoulos said at the Fusion2006 CEO-CIO ... work they do that does not support their core competency ... expect, a discussion of outsourcing versus doing work in house ... the Delphi Group founder to tap his experience in IT ...
... Robert Paulos, associate director for the IceCube project, holds ... IceCube neutrino telescope. Photo courtesy of the Ice Cube ... of scientists and engineers has taken a major step ... cosmic neutrino observatory, harnessing a sophisticated hot-water drill to ...
... have been infected with the H5N1 avian influenza virus, mostly ... virus does not spread easily from its pioneering human hosts ... a study of cells in the human respiratory tract reveals ... that makes it difficult for the virus to jump from ...
Cached Biology Technology:IT outsourcing according to Tom Koulopoulos, part 1 2IT outsourcing according to Tom Koulopoulos, part 1 3Polar neutrino observatory construction leaps ahead 2Polar neutrino observatory construction leaps ahead 3Polar neutrino observatory construction leaps ahead 4UW shows why avian flu hasn't spread among humans yet 2UW shows why avian flu hasn't spread among humans yet 3
(Date:7/21/2015)... Passwords have proven futile for securing ... U.S. Office of Personnel Management breach. Biometric authentication ... but developers and end-users are concerned about how ... Biometrics-as-a-Service provider HYPR Corp. announced today the general ... party integration. A video overview ...
(Date:7/9/2015)...  Synaptics Inc. (NASDAQ: SYNA ), a leading developer ... report financial results for the fourth quarter and fiscal ... close of market. The company will host a corresponding ... PT (5:00 p.m. ET), during which management may discuss ... live call, analysts and investors should dial 888-455-2260 (conference ...
(Date:7/8/2015)... YORK , July 8, 2015 Summary ... globally, and the fourth most fatal, with a mortality ... The poor prognosis of pancreatic cancer patients has highlighted ... treatment, which is not being met by the current ... an array of products with varying molecule types and ...
Breaking Biology News(10 mins):HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3
... at LSU's Museum of Natural Science, or LSUMNS, and ... species of lizard while conducting field research in Borneo. ... the Institute of Biodiversity and Environmental Conservation at the ... of the new species in the prestigious Journal of ...
... visiting biologist at the University of California, San Diego ... that there are close linkages between outbreaks of Ebola ... climate may influence the spread of the disease. , ... date of January) in the journal Transactions of the ...
... have been responsible for the deadly 1998?000 outbreak of ... Republic of the Congo, according to an article in ... Journal of Medicine. , Daniel G. Bausch, associate ... Public Health and Tropical Medicine and an international team ...
Cached Biology News:LSU professor discovers new species 2Pattern of human Ebola outbreaks linked to wildlife and climate 2Pattern of human Ebola outbreaks linked to wildlife and climate 3Pattern of human Ebola outbreaks linked to wildlife and climate 4
... numbers of samples may be carried out using ... minimum operator attention. System control and data ... CE 4900. The elegant, powerful and very ... and Windows 98 and 2000., The supplied automatic ...
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (F1676) or contact customer s...
... This CLS number is a new ... Cornings product number. If showing no ... old Sigma-Aldrich number (E6152) or contact ... Dim: H diam. 11.25 ...
A convenience pack containing one each of the most popular sizes of Cat. No. 4980 flask. Designed for the low volume user, a case contains one each of five sizes: 50mL, 125mL, 250mL, 500mL, and 1L....
Biology Products: