Navigation Links
New cow genome sequence released
Date:4/23/2009

Scientists from the University of Maryland have published their assembly of the domestic cow (Bos taurus), an important new resource for the genetics community. The new version of the cow genome improves considerably on other assemblies, in terms of both completeness and accuracy. The article describing their research is freely available in BioMed Central's open access journal Genome Biology.

The research team led by Steven Salzberg developed special-purpose software to assemble 35 million DNA sequence fragments into the 30 chromosomes that make up the Bos taurus genome. The algorithms use paired-end sequence information, mapping data, and synteny with the human genome to detect errors, correct inverted segments and fill in sequence gaps. The resulting assembly has around 91% of the assembled genome anchored onto chromosomes.

The researchers believe their assembly is the best available, thanks to its completeness and the algorithm's ability to smooth out thousands of errors. Their comparisons demonstrate that the new cow genome assembly has better agreement with independent genetic maps, and a more complete representation of cow genes, than alternative assemblies.

The new assembly places some 150 million nucleotides (6%) more DNA sequence data onto chromosomes than the other draft assembly currently available, BosTau4.0 from the Baylor College of Medicine (BCM4). A new, expanded cow-human synteny map increases the number of syntenic breakpoints by approximately 30%. Salzberg's team also pinpointed a portion of the Bos taurus Y chromosome for the first time.

"Until the assembly is truly finished - a state that no mammalian genome, including human, has yet reached - we will continue to incorporate new data to fill in gaps, to correct the mis-oriented regions, and to place more sequences onto chromosomes," says Salzberg. The alpaca and sheep genomes are currently being sequenced, and should provide a rich source for making further improvements between these closely related mammals.

Although sequencing and assembly of mammalian genomes has become commonplace since the human genome was first sequenced seven years ago, assembling large genomes accurately remains a challenge.


'/>"/>

Contact: Charlotte Webber
charlotte.webber@biomedcentral.com
44-203-192-22216
BioMed Central
Source:Eurekalert

Related biology technology :

1. Human Genome Sciences Announces $40 Million Milestone Payment Related to Albuferon(R) Development
2. GenVault Partnership with Genome Quebec Brings $3.3 Million Sale of Dynamic Archive Product
3. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at Thomas Weisel Partners Conference
4. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at BioCentury-Thomson Financial Investment Conference
5. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at Bear Stearns Conference
6. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at Merrill Lynch Conference
7. BioNanomatrix Announces Issuance of Key Nanofluidics Patent Enabling Single Molecule Whole Genome Analysis
8. BioNanoatrix and Complete Genomics Receive $8.8 Million NIST-ATP Award to Develop Sequencing Platform for $100 Genome
9. Individual differences caused by shuffled chunks of DNA in the human genome
10. BioNanomatrix and Complete Genomics Receive $8.8 Million NIST-ATP Award to Develop Sequencing Platform for $100 Genome
11. Sir Walter Bodmer Joins Oxford Genome Sciences Scientific Advisory Board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... USA (PRWEB) , ... May 23, 2017 , ... Federal ... as well as an enabler of life-saving medical and other vital technologies — deserves ... . They joined others in the scientific community today in responding to the President’s ...
(Date:5/23/2017)... ... May 23, 2017 , ... A recent survey conducted by the Weed Science ... control weed in 12 categories of broadleaf crops, fruits and vegetables, while common lambsquarters ... U.S. and Canada participated in the 2016 survey, the second conducted by WSSA. ...
(Date:5/23/2017)... ... May 22, 2017 , ... A new ... San Diego, California, this August will feature high-level speakers on quantum devices, graphene ... SPIE Optics and Photonics, the largest multidisciplinary optical sciences meeting in North America, ...
(Date:5/23/2017)... , ... May 23, 2017 , ... Bacterial biofilms, surface ... molecules, can cause diverse pathologies ranging from food poisoning and catheter infections to gum ... is in the tens of billions of dollars per year, there is currently a ...
Breaking Biology Technology:
(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
(Date:3/27/2017)... 27, 2017  Catholic Health Services (CHS) has ... Society (HIMSS) Analytics for achieving Stage 6 on ... . In addition, CHS previously earned a place ... an electronic medical record (EMR). "HIMSS ... of EMR usage in an outpatient setting.  This ...
(Date:3/24/2017)... 2017 Research and Markets has announced the ... & Trends - Industry Forecast to 2025" report to their ... The Global ... CAGR of around 15.1% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
Breaking Biology News(10 mins):