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New approaches needed to gauge safety of nanotech-based pesticides
Date:10/4/2010

said.

But researchers need to be equally realistic about the dangers, she said. OSU labs have tested more than 200 nanomaterials, and very few posed any toxic concerns but a few did. In one biomedical application, where nanoparticles were being studied as a better way to deliver a cancer drug, six out of 40 evoked a toxic response, most of which was linked to a specific surface chemistry that scientists now know to avoid.

"The emergence of nanotechnology in the pesticide industry has already begun, this isn't just theoretical," said David Stone, an assistant professor in the OSU Department of Environmental and Molecular Toxicology. "But pesticides are already one of the most rigorously tested and regulated class of compounds, so we should be able to modify the existing infrastructure."

One important concern, the researchers said, will be for manufacturers to disclose exactly what nanoparticles are involved in their products and what their characteristics are. Another issue is to ensure that compounds are tested in the same way humans would be exposed in the real world.

"You can't use oral ingestion of a pesticide by a laboratory rat and assume that will tell you what happens when a human inhales the same substance," Stone said. "Exposure of the respiratory tract to nanoparticles is one of our key concerns, and we have to test compounds that way."

Future regulations also need to acknowledge the additional level of uncertainty that will exist for nano-based pesticides with inadequate data, the scientists said in their report. Tests should be done using the commercial form of the pesticides, a health surveillance program should be initiated, and other public educational programs developed.

Special assessments may also need to be developed for nanoparticle exposure to sensitive populations, such as infants, the elderly, or fetal exposure. And new methodologies may be required to understand nanoparticle effects, whic
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Contact: Stacey Harper
harpers@science.oregonstate.edu
541-737-2791
Oregon State University
Source:Eurekalert

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