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New approach may render disease-causing staph harmless
Date:2/14/2008

tallography to determine the structure of the enzyme and how it interacts with the inhibitors.

Our structural studies pinpointed how these drug candidates bound to the bacterial enzyme to shut off pigment production, Wang said.

The new findings are particularly promising because BPH-652 already has been used (as a cholesterol-lowering agent) in human clinical trials, reducing the cost and time for development.

This research is an excellent example of how discoveries at the lab bench can lead to clinical advances, said Dr. Elias A. Zerhouni, the director of the National Institutes of Health, which supported the research. By following their scientific instinct about a basic biological process, the researchers found a promising new strategy that could help us control a very timely and medically important health concern.


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Contact: Diana Yates
diya@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

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