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New Study Finds Growth Factor Boosts Productivity in Mammalian Cell Culture

Leading researchers in academia and industry reveal powerful effects of recombinant lactoferrin (tradename: Lacromin) in mammalian cell culture

leading to a significant boost in productivity.

FORT COLLINS, Colo., Oct. 10 /PRNewswire/ -- A recently published study in the scientific journal In Vitro Cellular & Developmental Biology revealed that recombinant lactoferrin (tradename: Lacromin, see is a strong growth factor for promoting cell growth and cell productivity across a variety of cell lines, including intestinal cells, hybridoma cells, osteoblast cells and embryonic kidney (293) cells.

A global collaborative research effort led to the findings. The study included research conducted by two prestigious international research institutions: University of Auckland in New Zealand and Barts & The London Queen Mary's School of Medicine & Dentistry in London. Also, cell culture industry researchers at the following companies contributed to these findings:

-- HyClone Inc in Logan, Utah;

-- KC Bio in Kansas City, Missouri; and

-- InVitria in Fort Collins, Colorado.

Dr. Ning Huang, Vice President of Research and Development for InVitria, coordinated the study entitled, "Bioactive recombinant human lactoferrin, derived from rice, stimulates mammalian cell growth (1)."

"In working with research collaborators in the industry and leading academic centers around the world, recombinant lactoferrin has been shown to promote cell growth and productivity in a variety of cell lines and also improves antibody product yields in mammalian cell culture," said Dr. Huang. "Since recombinant lactoferrin is well defined, it is an important component for adapting cells and transitioning cells from serum to animal free and completely defined cell culture media."

"We have discovered that recombinant lactoferrin is an important growth factor in bone cell culture media," said Professor Jillian Cornish, Department of Medicine, Faculty of Health and Medical Sciences at University of Auckland. "Not only did we see improved growth of osteoblasts, but we also found that growth increased with greater amounts of recombinant lactoferrin."

About InVitria (

InVitria has developed cell culture media components that enhance productivity, safety and time to market for companies in the biopharmaceutical, mammalian cell culture, regenerative medicine, cell therapy, stem cell and diagnostics industry. InVitria's recombinant human lactoferrin called Lacromin ( was utilized in this study.

For more detailed product information requests or to order re-prints of the above-mentioned article contact InVitria by e-mail or phone.

E-mail: Phone: 1-800-916-8311

(1) Huang, N. et al. Bioactive recombinant human lactoferrin, derived from

rice, stimulates mammalian cell growth. In Vitro Cellular &

Developmental Biology. September 19, 2008 (E-publication Date).

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