Navigation Links
New Study Confirms Texas Fertility Center Research About Increasing Pregnancy Rates with Frozen Embryo Transfer
Date:10/11/2017

A new study published in Fertility and Sterility in August compared the implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort study examined the contribution of progesterone and maternal age to IVF success.

After comparing the results from the fresh and frozen transfer cohorts, the authors of the study determined that freeze-only transfer protocols produce statistically significantly higher implantation and pregnancy rates compared with fresh cycles, especially when the woman has a progesterone level >1.0 ng/mL at trigger. The results remained consistent for women both above and below age 35.

The study has lead researchers to conclude that fertility specialists should shift their embryo transfer protocols from fresh to frozen, confirming the results of research that Texas Fertility Center published two decades ago.

The first to prove the link between progesterone production, FET and IVF success

In 1991, Kaylen Silverberg, M.D., the medical director of Texas Fertility Center, and other experts in the field evaluated the effect of premature progesterone production on pregnancy rates in IVF cycles. They concluded that even minimally increased progesterone production prior to ovulation trigger significantly lowered pregnancy rates. These findings were confirmed by several other studies, however, unlike Silverberg and his colleagues, those authors suggested that progesterone adversely affected the eggs or embryos. In contrast, Silverberg hypothesized that progesterone caused the uterine lining to prematurely mature, while leaving the eggs and embryos unaffected. “We thought that high progesterone levels had a negative effect on the uterine lining, not the eggs and embryos,” said Dr. Silverberg.

To determine a definitive answer, he and his colleagues then performed a study looking specifically at embryos that were frozen rather than transferred fresh. When they compared pregnancy rates, they found that embryos frozen from cycles with elevated progesterone levels provided the same chance for pregnancy as embryos frozen from cycles with lower progesterone levels. This confirmed their belief that progesterone affected the uterine lining rather than the egg or the embryo. The results of the study, published in 1994, were groundbreaking – rather than canceling IVF cycles due to premature progesterone production, fertility specialists learned they could simply freeze all of a patient’s embryos for transfer during a later cycle. The reproductive endocrinologists at Texas Fertility Center continued these studies and began performing only frozen embryo transfers several years ago.

Freezing embryos allows fertility specialists to transfer embryos into a woman’s uterus once progesterone levels have dropped and the uterine lining has returned to an optimal condition for implantation.

Research supports protocols for FET

“The team at Texas Fertility Center is known for performing leading-edge research and incorporating these findings into everyday practice for our patients. Frozen embryo transfers have been an integral part of our IVF practice for decades at Texas Fertility Center, and the new research in Fertility and Sterility confirms our initial research, as well as our shift to frozen embryo transfer protocols,” said Dr. Silverberg.

________________________________________
About Dr. Kaylen Silverberg

Dr. Silverberg has served two terms on the board of directors for the Society for Assisted Reproductive Technologies (SART). Dr. Silverberg has also been honored by the American Fertility Association with their national Family Building Award, and is recognized annually as a Best Doctor in America™. Actively involved in infertility research for more than two decades, Dr. Silverberg has published his findings extensively in infertility journals and textbooks of infertility and gynecology. He is a founder of Ovation Fertility™ and Ovation Fertility™ Genetics, national leaders in IVF and pre-implantation genetic embryo testing. Dr. Silverberg is board-certified in obstetrics and gynecology as well as reproductive endocrinology/infertility.

For more information, please visit http://www.txfertility.com.

Read the full story at http://www.prweb.com/releases/2017/09/prweb14730471.htm.


'/>"/>
Source: PRWeb
Copyright©2017 Vocus, Inc.
All rights reserved


Related biology technology :

1. SD Mines BuG ReMeDEE Team Lands $6 Million Grant to Study Microbes of the Methane Cycle in Extreme Environments
2. Heart failure caregivers face critical gaps in resources and support, new international study shows
3. New Case Study Shows How Product Inspection Technology Facilitates CPG Growth
4. Therapixs First-in-Class Therapy Demonstrates Reversal of Age-Related Cognitive Impairment in Pre-Clinical Study
5. DrugDev to Promote Adoption of Innovative Technologies to Advance Clinical Study Efficiency at Prestigious Pharma and Biotech Industry Conferences in Q4
6. Kessler Foundation study shows neuromechanical effects of exoskeleton-assisted walking in spinal cord injury
7. Matrix IT Wins AIM 2017 AIDC Case Study Competition
8. Orange County Water District Leads National Science Foundation Funded Study of the Metagenomics of Water Quality
9. PRC Clinical Announces Completion of First Patient Cohort in UC Davis Regenerative Medicine Study in Musculoskeletal Diseases
10. MMJ BioScience Moving Forward with Cannabis Multiple Sclerosis FDA Study
11. Study Finds Visual Evoked Potential Identifies Concussion History
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... 12, 2017 , ... DuPont Pioneer and recently formed CasZyme, ... into a multiyear collaboration to identify and characterize novel CRISPR-Cas nucleases. The goal ... editing across all applications. , Under the terms of the agreement, Pioneer will ...
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces expanded ... of its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market for ... fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS estimates ...
(Date:10/12/2017)... CA (PRWEB) , ... October ... ... (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform specifically designed ... bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, who made ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... gene in its endogenous context, enabling overexpression experiments and avoiding the use of ... small RNA guides is transformative for performing systematic gain-of-function studies. , This ...
Breaking Biology Technology:
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
(Date:3/30/2017)... March 30, 2017 The research team of ... three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae ... realm of speed and accuracy for use in identification, crime investigation, ... cost. ... A research ...
Breaking Biology News(10 mins):