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New Shire Holding Company Proposal
Date:4/16/2008

BASINGSTOKE, England and PHILADELPHIA, April 16 /PRNewswire-FirstCall/ -- Shire plc ("Shire" or the "Company") (LSE: SHP) (NASDAQ: SHPGY), the global specialty biopharmaceutical company, announces that further to yesterday's announcement regarding Shire's new holding company proposal, it will today post the Circular and associated documents to its shareholders. A Prospectus, in relation to the ordinary shares in the new Shire holding company, to be called Shire Limited, has been published and both the Prospectus and Circular have been posted on the Company's website: http://www.shire.com.

Copies of the Circular and Prospectus have been submitted to the UK Listing Authority and are available for inspection at the Document Viewing Facility, which is situated at The Financial Services Authority, 25 The North Colonnade, Canary Wharf, London E14 5HS, tel. +44-20-7066-1000.

Notes to editors

SHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe. Shire believes that a carefully selected portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

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