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New SPE Cation Exchange Technology From Varian Simplifies Extraction of Basic Compounds

PALO ALTO, Calif., Oct. 22 /PRNewswire-FirstCall/ -- Varian, Inc. (Nasdaq: VARI) announced today the release of Bond Elut Plexa(TM) PCX, a new addition to the Plexa family. Bond Elut Plexa and Plexa PCX comprise an advanced generation of polymers for solid phase extraction (SPE), designed for ease of use and improved analytical performance. SPE is used by analytical chemists to concentrate and clean up compounds of interest from their surrounding sample matrices for analysis by liquid chromatography/mass spectrometry (LC/MS).

Plexa and Plexa PCX are high performance polymers using novel formats and methods for high throughput automation and simple method development. Bond Elut Plexa is a general purpose choice for a wide range of acid, basic and neutral analytes. Plexa PCX is designed specifically to provide a single, simple extraction method for basic compounds. Both are ideal for applications in pharmacokinetics, pharmacodynamics, forensics, toxicology, food safety and environmental investigation.

Plexa PCX uses a polymer cation exchange mechanism that combines the outstanding properties of Bond Elut Plexa -- superior flow characteristics and improved analytical performance -- with strong cation exchange capability. This advanced SPE sorbent effectively removes neutral and acidic interferences from the sample matrix and concentrates basic analytes, resulting in improved sensitivity, quantification and analytical performance.

The Plexa range of SPE products delivers faster flow rates because the particles have much smaller spaces between them with no fines to cause blockages. Results are more reproducible because the polymer particles are more regular and uniform. With Plexa PCX, a simplified, method for basic compounds is possible, reducing development time and costs. In addition, the Plexa range reduces ion suppression because of the unique polymer design -- the particle exterior excludes proteins and avoids strong binding of phospholipids, and so efficient removal of phospholipids from biological samples is ensured.

"Plexa PCX builds on the success of Bond Elut Plexa, offering an exciting new choice for simplified, high performance sample processing", says Martin O'Donoghue, Senior Vice President, Scientific Instruments, Varian, Inc. "Both products make excellent use of sophisticated polymer resins, supported by optimized methods to provide faster, better SPE results in a high-throughput laboratory environment."

For more technical information about Varian's SPE consumables, please visit

Varian, Inc. is a leading worldwide supplier of scientific instruments and vacuum technologies for life science and industrial applications. The company provides complete solutions, including instruments, vacuum components, laboratory consumable supplies, software, training and support through its global distribution and support systems. Varian, Inc. employs approximately 3,800 people and operates manufacturing facilities in 13 locations in North America, Europe and Asia Pacific. Varian, Inc. had fiscal year 2006 sales of $835 million, and its common stock is traded on the NASDAQ Global Select Market under the symbol, "VARI". Further information is available on the company's Web site:

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