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New Research Shows Many Patients with Persistent Cough and Sputum Actually had Airway Obstruction Consistent with COPD
Date:10/28/2008

), was comprised of seven questions related to respiratory symptoms, smoking history and age.

About the Lung Function Questionnaire

Data was also presented at CHEST 2008 on the development of the Lung Function Questionnaire (LFQ), a patient screening tool to help identify patients at risk for airflow obstruction who are candidates for spirometry and to help address undiagnosed COPD issues.

The LFQ is being developed in 3 phases: 1) Empirical phase: candidate questionnaire items were identified and their accuracy evaluated using data from NHANES III; 2) Qualitative phase: questions identified in phase 1 were evaluated for clarity by patients/clinicians; 3) Quantitative phase: ongoing validation study of the LFQ in screening for airway obstruction. The LFQ contained age, wheeze, dyspnea, smoking and phlegm as questions being predictive of airflow obstruction. LFQ demonstrates moderate screening accuracy both in a chronic bronchitis population as well as in a general population in NHANES. Additional validation studies are underway to further evaluate LFQ in a general population.

Background on COPD

An estimated 24 million Americans suffer from COPD, which is the fourth leading cause of death in the United States. COPD is a progressive, life- threatening lung disease that includes chronic bronchitis and emphysema. It is characterized by airflow obstruction, a limitation in lung function that makes it difficult to breathe. Many patients have components of both chronic bronchitis and emphysema. Symptoms of COPD include chronic cough, chest tightness, shortness of breath, an increased effort to breathe and increased mucus production. Typically, patients with COPD develop shortness of breath during exertion, which continues and gradually worsens. Most patients also develop a productive, chronic cough. Over time, many patients suffer from shortness of breath so severe that it interferes with their most basic daily activities including sleepi
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SOURCE GlaxoSmithKline
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