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New Research Shows Many Patients with Persistent Cough and Sputum Actually had Airway Obstruction Consistent with COPD
Date:10/28/2008

on all patients. Albuterol was self-administered for determination of post- bronchodilator FEV(1)/FVC ratio, post-albuterol FEV(1)% of predicted normal and FEV(1) reversibility. All patients had self-reported symptoms of chronic bronchitis and were current or previous cigarette smokers with a history of cigarette smoking of > or = 10 pack-years. COPD was defined as a post- bronchodilator FEV(1)/FVC < or = 0.7.

COPD is characterized by a progressive airflow limitation that is not fully reversible and is associated with an abnormal inflammatory response of the lungs, primarily caused by smoking. The range of conditions described by COPD, which include chronic bronchitis and emphysema, has led to confusion about disease terminology and difficulty with diagnosis especially in the primary care setting. Despite the availability of effective medicines to help manage the disease, many patients with COPD remain undiagnosed and under- treated. This study aimed to characterize airway obstruction, patient characteristics, and patient and provider awareness and understanding of COPD in primary care patients with symptoms of chronic bronchitis.

About the Study

This was a multi-center, cross-sectional study of more than 1,200 subjects 40 years of age and older with a minimum 10 pack-year smoking history and symptoms of chronic bronchitis recruited from primary care centers. There was no treatment intervention in the study. Each study subject completed a single visit encompassing all study procedures, which included two questionnaires completed by each study subject. One questionnaire was a compilation of the medical research council (MRC) dyspnea scale, the 12-item Short Form Health Survey (SF-12, version 2), a modified American Thoracic Society (ATS) respiratory questionnaire, and additional questions about disease and smoking history, work and non-work activities missed due to breathing problems. The other questionnaire, The Lung Function Questionnaire (LFQ
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SOURCE GlaxoSmithKline
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