Navigation Links
New Research Identifies Novel Target for Controlling Immune Response to Implanted Materials
Date:3/20/2017

NEW YORK, March 20, 2017 /PRNewswire-USNewswire/ -- Researchers at MIT and Boston Children's Hospital have published a report today in the journal Nature Materials that provides a better understanding of the body's immune responses to the materials used in implanted medical devices. Funding for this study is made possible through collaboration between JDRF and The Leona M. and Harry B. Helmsley Charitable Trust.

The report, "Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates," could have a significant impact on our future ability to prevent immune rejection of devices that treat type 1 diabetes (T1D), including infusion sets, sensors for continuous glucose monitors (CGMs), and in particular, cell encapsulation and transplantation devices.

"Tens of millions of people in the United States are living with implanted biomedical devices or devices that penetrate the skin. For people with type 1 diabetes, these advances could help improve insulin pump infusion sets, continuous glucose monitors and encapsulation therapies," said Aaron Kowalski, Ph.D., JDRF Chief Mission Officer. "By understanding how to target and prevent unnecessary immune responses to the materials used in medical devices, we can provide therapies that work more effectively and with fewer negative side effects. That would be an incredible step forward in JDRF's mission to cure, prevent and treat T1D."

The study, conducted in rodents and non-human primates, found a significant increase in immune response from colony stimulating factor-1 binding its receptor (CSF1R) following implantation of multiple biomaterial classes such as ceramic, polymer and hydrogel. It also found that specifically targeting CSF1R improved biocompatibility and reduced the thickening and scarring of connective tissue known as fibrosis without the need for broad immunosuppression that would inhibit necessary immune functions like wound healing.

"This gives us a better understanding of the biology behind fibrosis and potentially a way to modulate that response to prevent the formation of scar tissue around implants," said Daniel Anderson, an associate professor in MIT's Department of Chemical Engineering, a member of MIT's Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science (IMES), an affiliate at Boston Children's Hospital, and the senior author of the study.

"One of the things that is particularly exciting to me is that this is one of the first studies to really examine the fundamentals of how the immune system interacts with implantable biomaterials," said Robert Langer, the David H. Koch Institute Professor at MIT and a research associate at Boston Children's Hospital, who was another author of the paper.

Currently, devices like CGMs and infusion sets for insulin pumps must be changed regularly because the body's immune response causes what's known as a fibrotic cascade, preventing the device from interacting with the surrounding microenvironment – making it impossible for the devices to sense glucose levels or effectively deliver insulin. In addition, non-biodegradable microcapsules and macrodevices are being tested to immunoisolate transplanted islet cells in people with T1D, however immune and fibrosis responses directed at the encapsulation material contribute to the failure of the device. Overcoming the rejection of implanted medical devices without the use of broad-spectrum anti-inflammatory drugs could improve the lifespan and effectiveness of the devices, as well as the quality of life for people managing T1D on a daily basis.

This research was supported by grants from JDRF, The Leona M. and Harry B. Helmsley Charitable Trust, the National Institutes of Health, and the Tayebati Family Foundation.

To learn more about research funded by JDRF, visit www.jdrf.org/research.  

Reference: Nature Materials

About JDRF
JDRF is the leading global organization funding type 1 diabetes (T1D) research. Our mission is to accelerate life-changing breakthroughs to cure, prevent and treat T1D and its complications. To accomplish this, JDRF has invested more than $2 billion in research funding since our inception. We are an organization built on a grassroots model of people connecting in their local communities, collaborating regionally for efficiency and broader fundraising impact, and uniting on a national stage to pool resources, passion, and energy. We collaborate with academic institutions, policymakers, and corporate and industry partners to develop and deliver a pipeline of innovative therapies to people living with T1D. Our staff and volunteers throughout the United States and our six international affiliates are dedicated to advocacy, community engagement and our vision of a world without T1D. For more information, please visit jdrf.org or follow us on Twitter: @JDRF

 

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/new-research-identifies-novel-target-for-controlling-immune-response-to-implanted-materials-300426292.html


'/>"/>
SOURCE JDRF
Copyright©2017 PR Newswire.
All rights reserved


Related biology technology :

1. Global $7.52 Billion Next Generation Sequencing Market Assessment & Forecast: 2017-2021 - Opportunities in Reagents and Consumables Segment - Research and Markets
2. Three Day Biotechnology for the Non-Biotechnologist Course (London, United Kingdom - September 27-28-29, 2017) - Research and Markets
3. Global $1.47 Billion Biostimulants Market to 2022 - Research and Markets
4. PMG Research Announces Clinical Trial Community with Smart Patients
5. Cellecta, Inc. Announces Upcoming Presentations at the American Association for Cancer Research 2017 Annual Meeting
6. ABCs 2016 Norman R. Farnsworth Excellence in Botanical Research Award Granted to Her Excellency Ameenah Gurib-Fakim
7. Global Bioplastics Market - Trends and Forecasts (2016-2021) - Global Production Capacity Will Rise to 7.6 Million Metric Tonnes by 2019 - Research and Markets
8. Global Bioinsecticides Market to Reach $774 Million by 2020 - Growth Primarily Attributed to Advancements in Biopesticides Industry - Research and Markets
9. Rosalind Franklin University announces construction of new Innovation and Research Park
10. SRI International Awarded Two BARDA Contracts to Provide Nonclinical Research Services
11. Molecular Assemblies Appoints Floyd E. Romesberg from The Scripps Research Institute to Scientific Advisory Board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... ... August 15, 2017 , ... Any expert in stem cell research ... disciplines for more than half a century. Despite their essential roles in human ... widely known that molecular tags developed for this purpose also tag other, more abundant, ...
(Date:8/14/2017)... ... August 14, 2017 , ... Every ... Key researchers in the antibody community have recently come together to address this ... in the laboratory. , The team at Thermo Fisher Scientific ...
(Date:8/11/2017)... , ... August 11, 2017 , ... Algenist continues to ... formulation unlocking collagen like never before. , Collagen is the key structural element ... market with Liquid Collagen™, which include: , First to ...
(Date:8/10/2017)... Durham, NC (PRWEB) , ... August 09, 2017 , ... ... fractures. Almost half never recover well enough to live an independent lifestyle and, even ... , A new discovery by doctors at the University of California Davis Medical ...
Breaking Biology Technology:
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
(Date:3/27/2017)... 27, 2017  Catholic Health Services (CHS) has ... Society (HIMSS) Analytics for achieving Stage 6 on ... . In addition, CHS previously earned a place ... an electronic medical record (EMR). "HIMSS ... of EMR usage in an outpatient setting.  This ...
(Date:3/22/2017)... March 21, 2017   Neurotechnology , a ... technologies, today announced the release of the ... provides improved facial recognition using up to 10 ... single computer. The new version uses deep neural-network-based ... and it utilizes a Graphing Processing Unit (GPU) ...
Breaking Biology News(10 mins):