Montclare says arriving at the right FH/mTat structure was more trial and error than complex manipulation. "Some have tried to make lipids that are 'decorated' with peptides, but those require sophisticated chemistries," she says. "But we thought, 'Let's do the simplest thing,' namely taking the two entities and just mix them to find the best combinations." She says her team went through a number of trials to find combinations with the best transfection efficiencies. "It seems to work, and it doesn't require complicated chemistries to conjugate one with the other; we essentially just mix them in a pot," she says.
The joint research from Yamano's and Montclare's labs was published in the Journal of Controlled Release, a prestigious journal for drug and gene delivery.
About Polytechnic Institute of New York University
Polytechnic Institute of New York University (formerly Polytechnic University), an affiliate of New York University, is a comprehensive school of engineering, applied sciences, technology and research, and is rooted in a 157-year tradition of invention, innovation and entrepreneurship: i-squared-e. The institution, founded in 1854, is the nation's second-oldest private engineering school. In addition to its main campus in New York City at MetroTech Center in downtown Brooklyn, it also offers programs at sites throughout the region and around the globe. Globally, NYU-Poly has programs in Israel, China and is an integral part of NYU's campus in Abu Dhabi. For more information, visit www.poly.edu.
About New York University College of Dentistry
Founded in 1865, New York University College of Dentistry (NYUCD) is the third oldest and the largest dental school in the U.S., educating more than eight percent of all dentists. NYUCD has a significant glo
|SOURCE Polytechnic Institute of New York University|
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