Navigation Links
New Research Helps Explain Weakened Immune Response in Elderly
Date:1/8/2013

ng how and when these clonal expansions develop is a key focus of aging research.

The Trudeau team developed in a mouse model a sensitive new assay that allowed them to track the early development of these clonal expansions and test their impact on the ability of the mice to respond to re-infection. Their data show that the clonal composition of the virus-specific memory CD8+ T cell pool begins to change within months of the initial infection. These early clonal perturbations eventually result in large clonal expansions that have been associated with aging.

Importantly, most of these expanded clones are significantly impaired in their capacity to mount recall responses to secondary challenge in vivo. However, as re-infection promotes the expansion of the normal memory cells in the pool, this raises the possibility that booster vaccination regimes could overcome the increasingly dysregulated immune response in the elderly.

These data illustrate how experiments in mouse models can reveal fundamental principles that can be applied to human medicine. The abstract for the paper can be accessed at http://www.immunityageing.com/content/9/1/28/abstract.

About the Trudeau Institute
The Trudeau Institute is a nonprofit biomedical research center founded in 1884 by Dr. E.L. Trudeau. The Institute's fundamental research on immunity fosters the development of vaccines, treatments and cures for many life-threatening diseases, including cancer, tuberculosis and influenza. The Institute is supported by federal and state grants and contributions from individuals, private foundations and corporations. For further information about the Trudeau Institute, go to

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Penn researchers show new level of control over liquid crystals
2. Market for Biologic Imaging Reagents and Medical Imaging & Diagnosing Analyzed in New Research Reports at ReportsnReports.com
3. Carin Grings remains identified by researchers at Uppsala University
4. LA Dental Bone Graft Substitute & Other Biomaterials Market Reviewed in New iData Research Report Available at MarketPublishers.com
5. Liquid crystal research, future applications advance
6. New funding to research super material graphene
7. National MS Society Reports Sweeping Advances Made in MS Research in 2012
8. Asia-Pacific Active Pharmaceutical Ingredients (APIs) Market Analysis & Forecasts to 2017 in New Research Report @ RnRMarketResearch.com
9. Mesenchymal Stem Cells Mobilize Body’s Own Healing Cells According to New Research Published in STEM CELLS Translational Medicine
10. APAC Stem Cell Research & Therapy Market a “Growth Engine” for Region’s Scientific Ambitions Says A New Market Research Report at ReportsnReports.com
11. Bayer CropScience Purchases Land Adjacent to its Research Triangle Park Headquarters
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... , July 29, 2014 According ... (Whole Slide Imaging), Analytics (Image Analysis Software), Delivery Modes ... Global Forecasts & Trends to 2018", published by MarketsandMarkets, ... in geographies such as North America ... , and the Rest of the World (RoW). ...
(Date:7/29/2014)... SPRINGS, Colo. , July 29, 2014 /PRNewswire/ ... specializing in cannabis formulation-based drug development and related ... York Times for taking a strong position in ... its Sunday, July 27, 2014 publication.  The New ... editorials and articles this week exploring the issue ...
(Date:7/29/2014)... Philadelphia’s newest entrepreneurial incubation space is ready for business, and ... Center @3401 , a collaborative effort of Drexel University ... help attract and nurture start-up businesses in the region, officially ... , The Innovation Center @3401 (ic@3401), which is located at ... home of DreamIt Ventures and Point.io ...
(Date:7/29/2014)... Seattle, WA (PRWEB) July 29, 2014 ... central IRB services, has been awarded accreditation by ... (IASSC) for its Lean Six Sigma Deployment ... eliminate waste and improve performance. , Quorum’s Lean ... granted the Accredited Deployment Program designation. The designation ...
Breaking Biology Technology:Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 2Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 3Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 2Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 3Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 2Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 3
... ... Support Innovative Start-up Companies and Entrepreneurs in Communications and Communications Convergence , ... San Diego, CA (PRWEB) June ... of Cricket Communications, Inc., a leading provider of unlimited wireless services, today announce their ...
... Germany, June 17 , - MedITEX ... Medicine , - MedITEX from 28 June ... , The IT consulting company CRITEX, which ... in vitro fertilisation, MedITEX IVF,at the 25th Annual Meeting of the ...
... 16 Microfluidic Systems, a privately-held company, announced ... "Sonication to Selectively Lyse Different Cell Types". This ... extraction of male/female DNA from a mixed forensic ... of biological sample processes for analysis and identification. ...
Cached Biology Technology:San Diego Wireless Heavyweight Leap Wireless Supports New Start-up Incubator 2San Diego Wireless Heavyweight Leap Wireless Supports New Start-up Incubator 3San Diego Wireless Heavyweight Leap Wireless Supports New Start-up Incubator 4New IVF Software MedITEX to be Presented at the ESHRE Exhibition 2MicroFluidic Systems (MFSI) Receives Patent for Method to Selectively Process Different Biological Cell Types for Analysis. 2
(Date:7/28/2014)... Eight of the top 10 U.S. cities that have ... public inconveniences as frequent road closures, overwhelmed storm drains ... a new NOAA technical report. , This nuisance flooding, ... three U.S. coasts, between 300 and 925 percent since ... Nuisance Flood Frequency Changes around the United States, also ...
(Date:7/28/2014)... of the Earth that are high priorities for conservation ... particularly vulnerable, as it has the lowest fraction of ... continent in ,refugia, areas of biological diversity that ... constant during times of great environmental change. The refugia ... and Scotland. , The biggest refugia are in ...
(Date:7/28/2014)... 2014) Rice University researchers are using magnetic beads ... that can be used as microscale models for polymer ... polymers, introduced as theory in the 1950s, can be ... should be of interest to materials scientists who study ... by Rice chemical and biomolecular engineer Sibani Lisa Biswal ...
Breaking Biology News(10 mins):NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 3Study finds Europe's habitat and wildlife is vulnerable to climate change 2Seeing is bead-lieving 2
... industry is being significantly challenged as production levels ... means for improving the industry,s competitiveness are being ... Manufacturing, Innovation, Trade, Resources and Energy (DMITRE) has ... to undertake a study that identifies potential routes ...
... restrictions have become unnecessarily restrictive and expensiveon Mars., ... astrobiologists Alberto Fairn of Cornell University and Dirk ... Office of Planetary Protection,s "detailed and expensive" efforts ... missions to search for life on the red ...
... Research Careers) Program has announced the travel award recipients ... in Immunology meeting in Boston, MA from July 28-August ... entry of students, postdoctorates and scientists from underrepresented groups ... to encourage the participation of young scientists at the ...
Cached Biology News:Bioeconomy as a solution for South Australia's declining forest industry 2Bioeconomy as a solution for South Australia's declining forest industry 3Researchers call for rethinking efforts to prevent interplanetary contamination 2
... Beacon Designer designs oligos for SYBR ... beacon, NASBA and FRET assays. Highly specific ... found by automatically interpreting BLAST search results. ... secondary structures identified by connecting to the ...
Human IL-17D Affinity Purified Polyclonal Ab...
... FHS-LVF and CVD-Diffuse We've combined our ... to create the world's first notch filter ... bandpass. Each filter features an excellent transmission ... These filters -- with interference coatings applied ...
Agar, 500 g. Noble Agar.Moisture: < 10%, ash: < 1.6%, EEO (-mr): < 0.450 (pH 8.4). Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Biology Products: