Navigation Links
New Research Helps Explain Weakened Immune Response in Elderly
Date:1/8/2013

Saranac Lake, New York (PRWEB) January 08, 2013

Researchers from the Trudeau Institute have recently uncovered abnormal behavior in aging cells that helps explain the loss of previously acquired immunity. The findings were made available yesterday on the website of the online scientific journal Immunity & Ageing.

The paper, titled “Early dysregulation of the memory CD8+ T cell repertoire leads to compromised immune responses to secondary viral infection in the aged,” was authored by Lisa M. Connor, Jacob E. Kohlmeier, Lynn Ryan, Alan D. Roberts, Tres Cookenham, Adam A. Quinn, Marcia A. Blackman, and David L. Woodland. The new information should be helpful to immunologists working to develop improved vaccine protocols for elderly populations.

The research team focused on “memory” T-cells, a type of white blood cell that fights infection and tumor development. Memory T-cells generated following an infection have the capacity to “remember” the prior pathogen; upon secondary exposure, they typically respond with accelerated speed and strength.

A key question for researchers is how these memory T-cells can be maintained into old age. It is well known that the memory pool becomes progressively dysregulated with age, such that large expansions of identical cells (or clones) occur in the elderly. These “clonal expansions” are found in most individuals and are thought to contribute to age-associated immune dysfunction.

Understanding how and when these clonal expansions develop is a key focus of aging research.

The Trudeau team developed in a mouse model a sensitive new assay that allowed them to track the early development of these clonal expansions and test their impact on the ability of the mice to respond to re-infection. Their data show that the clonal composition of the virus-specific memory CD8+ T cell pool begins to change within months of the initial infection. These early clonal perturbations eventually result in large clonal expansions that have been associated with aging.

Importantly, most of these expanded clones are significantly impaired in their capacity to mount recall responses to secondary challenge in vivo. However, as re-infection promotes the expansion of the normal memory cells in the pool, this raises the possibility that booster vaccination regimes could overcome the increasingly dysregulated immune response in the elderly.

These data illustrate how experiments in mouse models can reveal fundamental principles that can be applied to human medicine. The abstract for the paper can be accessed at http://www.immunityageing.com/content/9/1/28/abstract.

About the Trudeau Institute
The Trudeau Institute is a nonprofit biomedical research center founded in 1884 by Dr. E.L. Trudeau. The Institute's fundamental research on immunity fosters the development of vaccines, treatments and cures for many life-threatening diseases, including cancer, tuberculosis and influenza. The Institute is supported by federal and state grants and contributions from individuals, private foundations and corporations. For further information about the Trudeau Institute, go to http://www.trudeauinstitute.org.
###

Read the full story at http://www.prweb.com/releases/2013/1/prweb10298934.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. Penn researchers show new level of control over liquid crystals
2. Market for Biologic Imaging Reagents and Medical Imaging & Diagnosing Analyzed in New Research Reports at ReportsnReports.com
3. Carin Grings remains identified by researchers at Uppsala University
4. LA Dental Bone Graft Substitute & Other Biomaterials Market Reviewed in New iData Research Report Available at MarketPublishers.com
5. Liquid crystal research, future applications advance
6. New funding to research super material graphene
7. National MS Society Reports Sweeping Advances Made in MS Research in 2012
8. Asia-Pacific Active Pharmaceutical Ingredients (APIs) Market Analysis & Forecasts to 2017 in New Research Report @ RnRMarketResearch.com
9. Mesenchymal Stem Cells Mobilize Body’s Own Healing Cells According to New Research Published in STEM CELLS Translational Medicine
10. APAC Stem Cell Research & Therapy Market a “Growth Engine” for Region’s Scientific Ambitions Says A New Market Research Report at ReportsnReports.com
11. Bayer CropScience Purchases Land Adjacent to its Research Triangle Park Headquarters
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2016)... ... May 23, 2016 , ... Foresight Institute , ... the winners for the 2015 Foresight Institute Feynman Prizes. , These prestigious ... categories, one for experiment and the other for theory in nanotechnology. Prof. Markus ...
(Date:5/20/2016)... ... , ... Kablooe Design, a leading provider of product design and development services ... the business. “We have worked hard to build long-term relationships,” says President and CEO, ... honor of serving their product design and development needs through the years.” , Kablooe ...
(Date:5/19/2016)... (PRWEB) , ... May 19, 2016 , ... Anton Paar ... 30,000 square foot office building is complete. The new structure adds a third office ... Anton Paar USA purchased 2.4 acres of land, along with office space ...
(Date:5/19/2016)... , ... May 19, 2016 , ... ... organization (CRO) has welcomed Abu Siddiqui as Director, Large Molecule & Biomarker Bioanalysis. ... biologics, vaccine and translational biomarker discovery studies for preclinical and clinical safety programs. ...
Breaking Biology Technology:
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
(Date:4/28/2016)... First quarter 2016:   , ... the first quarter of 2015 The gross margin was ... 18.8) and the operating margin was 40% (-13) Earnings ... flow from operations was SEK 249.9 M (21.2) , ... SEK 7,000-8,500 M. The operating margin for 2016 is ...
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
Breaking Biology News(10 mins):