Navigation Links
New Research Helps Explain Weakened Immune Response in Elderly
Date:1/8/2013

Saranac Lake, New York (PRWEB) January 08, 2013

Researchers from the Trudeau Institute have recently uncovered abnormal behavior in aging cells that helps explain the loss of previously acquired immunity. The findings were made available yesterday on the website of the online scientific journal Immunity & Ageing.

The paper, titled “Early dysregulation of the memory CD8+ T cell repertoire leads to compromised immune responses to secondary viral infection in the aged,” was authored by Lisa M. Connor, Jacob E. Kohlmeier, Lynn Ryan, Alan D. Roberts, Tres Cookenham, Adam A. Quinn, Marcia A. Blackman, and David L. Woodland. The new information should be helpful to immunologists working to develop improved vaccine protocols for elderly populations.

The research team focused on “memory” T-cells, a type of white blood cell that fights infection and tumor development. Memory T-cells generated following an infection have the capacity to “remember” the prior pathogen; upon secondary exposure, they typically respond with accelerated speed and strength.

A key question for researchers is how these memory T-cells can be maintained into old age. It is well known that the memory pool becomes progressively dysregulated with age, such that large expansions of identical cells (or clones) occur in the elderly. These “clonal expansions” are found in most individuals and are thought to contribute to age-associated immune dysfunction.

Understanding how and when these clonal expansions develop is a key focus of aging research.

The Trudeau team developed in a mouse model a sensitive new assay that allowed them to track the early development of these clonal expansions and test their impact on the ability of the mice to respond to re-infection. Their data show that the clonal composition of the virus-specific memory CD8+ T cell pool begins to change within months of the initial infection. These early clonal perturbations eventually result in large clonal expansions that have been associated with aging.

Importantly, most of these expanded clones are significantly impaired in their capacity to mount recall responses to secondary challenge in vivo. However, as re-infection promotes the expansion of the normal memory cells in the pool, this raises the possibility that booster vaccination regimes could overcome the increasingly dysregulated immune response in the elderly.

These data illustrate how experiments in mouse models can reveal fundamental principles that can be applied to human medicine. The abstract for the paper can be accessed at http://www.immunityageing.com/content/9/1/28/abstract.

About the Trudeau Institute
The Trudeau Institute is a nonprofit biomedical research center founded in 1884 by Dr. E.L. Trudeau. The Institute's fundamental research on immunity fosters the development of vaccines, treatments and cures for many life-threatening diseases, including cancer, tuberculosis and influenza. The Institute is supported by federal and state grants and contributions from individuals, private foundations and corporations. For further information about the Trudeau Institute, go to http://www.trudeauinstitute.org.
###

Read the full story at http://www.prweb.com/releases/2013/1/prweb10298934.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. Penn researchers show new level of control over liquid crystals
2. Market for Biologic Imaging Reagents and Medical Imaging & Diagnosing Analyzed in New Research Reports at ReportsnReports.com
3. Carin Grings remains identified by researchers at Uppsala University
4. LA Dental Bone Graft Substitute & Other Biomaterials Market Reviewed in New iData Research Report Available at MarketPublishers.com
5. Liquid crystal research, future applications advance
6. New funding to research super material graphene
7. National MS Society Reports Sweeping Advances Made in MS Research in 2012
8. Asia-Pacific Active Pharmaceutical Ingredients (APIs) Market Analysis & Forecasts to 2017 in New Research Report @ RnRMarketResearch.com
9. Mesenchymal Stem Cells Mobilize Body’s Own Healing Cells According to New Research Published in STEM CELLS Translational Medicine
10. APAC Stem Cell Research & Therapy Market a “Growth Engine” for Region’s Scientific Ambitions Says A New Market Research Report at ReportsnReports.com
11. Bayer CropScience Purchases Land Adjacent to its Research Triangle Park Headquarters
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... 22, 2017   iSpecimen ®, the ... Doctors Pathology Service (DPS), a full-service anatomic pathology ... the United States , has joined a program ... Network (DHIN) to make human biospecimens and associated ... novel program, announced in 2015 as a collaboration between ...
(Date:3/22/2017)... /PRNewswire/ - FACIT announced a seed stage investment ... start-up created by FACIT focused on developing a ... with non-dilutive capital, achieves a targeted $3.0M financing ... Propellon to accelerate the nomination of a candidate ... entering a strategic partnership for clinical trials in ...
(Date:3/22/2017)... ... ... Premier executive recruitment firm, Slone Partners, is proud to have been named a Top ... Hunt Scanlon Media is one of the most respected life science publications in the ... sector. , “It is a great honor for Slone Partners to be part of ...
(Date:3/22/2017)... (PRWEB) , ... March 21, 2017 , ... Benchworks ... Science Chief Executive Officer Forum on March 23-24 in San Diego. The event ... device and diagnostic industries. , Benchworks Vice President Christian Meyer will also participate ...
Breaking Biology Technology:
(Date:3/9/2017)... MELBOURNE , Australia , March ... clinical study data at the prestigious World Lung Imaging ... Dr. Andreas Fouras , was invited to deliver ... and pulmonary medicine. This globally recognised event brings together ... and share the latest developments in lung imaging. ...
(Date:3/2/2017)... YORK , March 2, 2017 Summary ... better understand Perrigo and its partnering interests and activities since ... ... Partnering Deals and Alliance since 2010 report provides an in-depth ... leading life sciences companies. On demand company reports ...
(Date:2/28/2017)... ANGELES , Feb. 28, 2017   Acuant ... verification software globally, announces significant enhancements to new and ... May 2016. New products include mobile and desktop Acuant ... DocX TM - a real time manual review ... core idScan® technology provides the fastest and most accurate ...
Breaking Biology News(10 mins):