Navigation Links
New Preclinical Data Confirm Naurex's Novel Antidepressant GLYX-13 Appears Free of the Behavioral Impairment and Abuse Potential Seen With Ketamine
Date:12/7/2010

MIAMI and EVANSTON, Ill., Dec. 7, 2010 /PRNewswire/ -- Naurex Inc., a clinical-stage company developing innovative treatments to address unmet needs in psychiatry and neurology, reported that data being presented today at the 49th Annual Meeting of the American College of Neuropsychopharmacology (ACNP) further confirm that its lead antidepressant candidate GLYX-13 appears free of the behavioral impairment and abuse potential that have limited the clinical utility of other NMDA receptor (NMDAR) modulator drugs such as ketamine.

Ketamine and similar NMDAR-modulating agents act very rapidly to alleviate the symptoms of depression and bipolar disorder, but their clinical utility has been hampered by their potential for abuse and behavioral impairment, including schizophrenia-like effects, at doses near the therapeutic dose.  GLYX-13 is Naurex's lead glycine-site functional partial agonist (GFPA) selective modulator of the NMDA receptor.  The novel GFPA class of compounds has been specifically designed to achieve the well-documented efficacy of classic NMDAR-modulating drugs, while avoiding their serious side effects.

In previously reported preclinical studies, GLYX-13 demonstrated the robust antidepressant-like activity of ketamine, including its rapid onset and long duration of effect, with no signs of side effects.  In preclinical studies, GLYX-13 has demonstrated the widest therapeutic ratio between efficacy and side effects (>500:1) of any known NMDAR modulator.

In the new study, researchers employed a sophisticated preclinical model measuring whether subjects detect and respond to the presence of a specific drug.  Rats were trained to accurately discriminate whether ketamine or saline was present in a routine injection, by choosing one of two levers that delivers a reward when correctly matched to the injected substance.  The tests were run using increasing doses of ketamine and GLYX-13, including doses that are k
'/>"/>

SOURCE Naurex Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Aeterna Zentaris Presents Encouraging Preclinical Data on Two Novel Orally Active Anti-Cancer Compounds at Major Conference in Germany
2. Tarsa Therapeutics and Unigene Present Preclinical Data Suggesting Calcitonin May Have Utility in Combination Therapy for the Treatment of Osteoarthritis
3. Advanced Life Sciences Announces Successful Preclinical Data Supporting Restanza Intravenous Formulation for Hospital Use
4. Pieris Announces Positive Preclinical Data on c-Met Anticalin Drug Program
5. Mettler Toledo and PDS Pathology Data Systems Integrate Powerful Solutions for Faster and More Accurate Preclinical Studies
6. GeoVax Labs, Inc. Reports Data on Prototype Adjuvant - Supplemented HIV Vaccine Tested in Preclinical Animal Studies
7. NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate
8. Repligen Receives Second Research Grant from the Muscular Dystrophy Association to Support Friedreichs Ataxia Preclinical Development Program
9. Pajama Pathology -- the New Wave of Preclinical Pathology Embraced by PDS
10. AMT Successful in Preclinical Treatment of DMD
11. New approach for growing bone comes from Duke preclinical research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... this month, a report was created by Colorado ... Force on the performance of vehicles using an eco-friendly, ... fuel made from mustard seeds, offered great potential as ... friendly future. In fact, every branch of the U.S. ... foreign oil over the next few years. They will ...
(Date:8/27/2014)... August 27, 2014 Green & Grow ... Series B funding and secured Otter Capital as a ... will accelerate commercialization of GGI’s Agriplier™ technology, building on ... , “Since our first meeting, we have been ... biological product space,” said Alan Sobba, President and CEO ...
(Date:8/27/2014)... how plants survive impact by the huge amounts ... using this energy for photosynthesis. The hypothesis is ... quickly dissipate the energy throughout the entire protein ... Physics have now managed to successfully ,film, this ... light-absorbing proteins which play a role in photosynthesis ...
(Date:8/27/2014)... , Aug. 27, 2014  A novel ... to help physicians better identify early-stage disease, when ... disability, according to a new study in The ... Diagnostics (NYSE: DGX ) and other ... 14-3-3eta protein outperformed conventional antibody-serum testing, including rheumatoid ...
Breaking Biology Technology:Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3DTU researchers film protein quake for the first time 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4
... UCLA today announced the launch of the Mattel ... of personalized medicine for children, including the opportunities ... the world,s first dedicated solely to nanomedicine and ... a nanopediatrics program? Because children are not small ...
... 17 Bunge Limited,(NYSE: BG ), an integrated, ... the quarter ended September 30, 2008, on Thursday,October 23, ... management will host a conference call at 10:00 a.m.,EDT ... To listen to the conference call, please dial ...
... American Society of Anesthesiologists Annual Meeting as Masimo ... Oxygen Content (SpOC) monitor with live ... ... the inventor,of Pulse CO-Oximetry(TM) and Measure-Through-Motion-and-Low-Perfusion pulse,oximetry, announced today that ...
Cached Biology Technology:Mattel Children's Hospital UCLA launches program in nanopediatrics 2Bunge Limited Schedules Third Quarter 2008 Earnings Release and Conference Call 2Five New Clinical Studies Show Value of Masimo PVI & PI 2Five New Clinical Studies Show Value of Masimo PVI & PI 3Five New Clinical Studies Show Value of Masimo PVI & PI 4Five New Clinical Studies Show Value of Masimo PVI & PI 5
(Date:8/28/2014)... called TX Invasives is now available from the Lady ... at Austin for identifying harmful non-native plant, insect and ... the United States cause about $137 billion in economic ... clog waterways, kill native plants and more. , "By ... reporting where invasive species occur, we,re more likely to ...
(Date:8/28/2014)... America (ESA) is pleased to announce the selection of ... Society. Honorary Membership acknowledges those who have served ESA ... the affairs of the Society that has reached an ... the ESA Governing Board and then voted on by ... the Awards Ceremony at Entomology 2014, ESA,s Annual Meeting ...
(Date:8/28/2014)... have identified a handful of bacterial culprits that may ... and ulcerative colitis, using patients, own intestinal immune responses ... 28 in the journal Cell . , Trillions ... plays a critical role in the development and progression ... number of bacterial species affect a person,s susceptibility to ...
Breaking Biology News(10 mins):Mobile app makes ID of harmful plants, insects in Texas a snap 2Fred Baxendale selected as Honorary Member of the Entomological Society of America 2Yale study identifies possible bacterial drivers of IBD 2
... conodonts early vertebrates that kept their skeleton in their ... teeth (see image) and, like teeth, they were often worn ... conodonts evolved the first vertebrate dentitions. Scientists know that ... they are microscopic about 2 to 0.2 mm long ...
... A parking lot at the edge of the University ... emerging concern for the environment and human health. ... journal Environmental Science & Technology , has found that ... lots throughout the nation, has significant health and ecosystem implications. ...
... For the first time, scientists at the University of ... progenitor cells using induced pluripotent stem (iPS) cells derived ... retina structures showed the capacity to form layers of ... development and these cells possessed the machinery that ...
Cached Biology News:Size isn't everything -- it's how sharp you are 2UNH research adds to mounting evidence against popular pavement sealcoat 2Scientists produce eye structures from human blood-derived stem cells 2
Mouse NOV/CCN3 Affinity Purified Polyclonal Ab...
SNARE associated protein snapin, clone MGC:2717...
HiTrap NHS-activated HP, 1 x 5 ml. Category: Chromatography Systems & Accessories, Systems....
Human Serpin A8/AGT Affinity Purified Polyclonal Ab Keywords: Ang II, AngII, Hypertension, Salt Homeostasis, Pre-eclampsia...
Biology Products: