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New Phase III Data Demonstrate Oxycodone / Naloxone Combination Tablet Reduces Opioid-Induced Bowel Dysfunction in Patients With Chronic Severe Pain
Date:9/26/2007

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About oxycodone

Oxycodone is a full opioid agonist with affinity for mu (micro) and kappa (k) receptors. Its opioid agonist actions are similar to those of other opioid analgesics, primarily affecting the central nervous system and smooth muscle. It is used, in both prolonged-release and immediate-release formulations, across a broad spectrum of moderate to severe cancer and severe non-cancer related pain types such as somatic (e.g. osteoarthritis), neuropathic (e.g. diabetic neuropathy) and visceral (e.g. pancreatitis) pain. As with all pure opioid agonists, there is no ceiling effect to the analgesia seen with oxycodone.

References:

(1) Muller-Lissner S et al. Oral prolonged release oxycodone / naloxone combination reduces opioid-induced bowel dysfunction in patients with severe chronic pain, presented at the World Institute of Pain Congress, Budapest (Presented on 26.09.07, Poster 1134)

(2) Coluzzi, F et al. Minverva Anestesiol 2005; 71: 451-460

(3) Thorpe DM et al. Curr Pain headache Rep 2001; 5: 237-240

(4) De Schepper HU et al. Neurogastroenterol Motil 2004; 16: 383-394,5

(5) Gimbel JS et al. Neurology 2003; 60: 927-934

(6) Watson CP et al. Neurology 1998; 50 : 1837-1841

(7) Staahl C et al. Differential effect of opioids in patients with chronic pancreatitis: An experimental pain study. Scandinavian Journal of Gastroenterology 2007;42; (3)

(8) Staahl C et al. A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model. Pain 2006; 123:28-36

For further information, please contact:

Aoife Gallagher

Tel: +44-(0)20-7331-2324

Fax: +44-(0)20-7331-9084

Email: aoife_gallagher@uk.cohnwolfe.com


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