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New Phase III Data Demonstrate Oxycodone / Naloxone Combination Tablet Reduces Opioid-Induced Bowel Dysfunction in Patients With Chronic Severe Pain
Date:9/26/2007

oxone combination can reduce patients' risk of developing opioid-induced constipation whilst providing comparable pain relief to the highly effective oxycodone - this new approach to opioid-based pain management therapy may be of potential benefit to a large number of patients suffering from chronic pain and will address an important unmet clinical need."

Oxycodone is a strong opioid analgesic, used for the treatment of severe chronic pain. Its efficacy has been demonstrated across a broad spectrum of pain states such as somatic and neuropathic pain(5,6). Recent experimental data in healthy volunteers and patients with chronic pancreatitis also suggest that oxycodone may be useful for the treatment of severe visceral pain(7,8).

Naloxone is an opioid receptor antagonist that is used intravenously to reverse opioid overdose. Oral naloxone has negligible systemic bioavailability, which means it provides a full, local inhibitory effect on opioid receptors in the gut, thus reducing the impact of opioid-induced constipation, while having no effect on the analgesic efficacy of oxycodone and minimal central effects.

The oral PR oxycodone / naloxone combination tablet has been licensed in Germany under the trade name TARGIN(R) for adult patients with severe chronic pain and will be submitted for registration in other European countries.

Notes to Editors:

- TARGIN(R) is a Registered Trademark.

About Mundipharma International Limited

Mundipharma International Limited is one of the Purdue/Mundipharma/Napp independent associated companies - privately owned companies and joint ventures covering the world's pharmaceutical markets. The companies worldwide are dedicated to bringing to patients with severe and debilitating diseases the benefits of novel treatment options in fields such as severe pain, haemato-oncology and respiratory disease. For more information: http://www.mundipharma.co.
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