New Licence for Cubicin(R) (daptomycin), the First in a Novel Class of Antibiotic, is Announced Today for the Treatment of Serious Bloodstream and Heart Infections Caused by the Most Problematic UK Organisms, Including MRSA
... FRIMLEY England September 13 /- ...- Physicians Welcome New Option for Potentially Life ThreateningDisea...- Daptomycin has a Rapidly Bactericidal Mode of Action ...The launch of daptomycin for the treatment of bothmethicillin-sensiti...
Date:9/12/2007
FRIMLEY, England, September 13 /PRNewswire-FirstCall/ --
- Physicians Welcome New Option for Potentially Life Threatening
Disease
- Daptomycin has a Rapidly Bactericidal Mode of Action
The launch of daptomycin for the treatment of both
methicillin-sensitive and resistant Staphylococcus aureus (MSSA and MRSA)
bloodstream infections (bacteraemia) and heart infections (right-sided
infective endocarditis) has been announced today by Novartis
Pharmaceuticals UK Ltd.(1) Daptomycin, one of only two new classes of
antibiotic in over 20 years, has been shown to be as effective as existing
agents in treating a range of serious Gram-positive infections, offering an
important new option for healthcare professionals.
MRSA is a frequent cause of bacteraemia and is associated with serious
complications, including endocarditis (in 30-40% of cases) and has a high
mortality rate.(2) Over 7,000 people each year contract bacteraemia and the
incidence is rising.(3) From 1993 to 2005 the number of deaths increased
from 51 to 1,629.(4) There is evidence that some strains of MRSA are
developing resistance to existing antibiotic options.(5) Daptomycin, which
is rapidly bactericidal, has a specific mode of action, which reduces the
likelihood of resistance developing. Daptomycin's once daily dosing and
tolerability profile, with no need for therapeutic drug monitoring, has the
potential to simplify the management of patients with complicated
infections.
Dr Andrew Seaton, consultant in infectious diseases, Gartnavel general
hospital, Glasgow welcomed the news, commenting; "Serious staphylococcal
infections are extremely challenging for hospital specialists to treat,
with about 40% in the UK now resistant to first line therapy. Daptomycin is
a fast acting agent in these potentially difficult situations and is well
tolerated by patients. This is an extremely important and welcomed
development in the battle against serious MRSA infection."
Daptomycin is
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SOURCE Novartis Pharmaceuticals UK Ltd
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