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New Insights Link Low HDL-Cholesterol and Elevated Triglycerides With Coronary Heart Disease and Microvascular Complications in Patients at Goal for LDL-Cholesterol
Date:9/1/2009

- When moving from the lowest levels of TG and highest levels of HDL-C to the highest levels of TG and lowest levels of HDL-C, the risk of CHD increases 10-fold

Addressing atherogenic dyslipidemia may reduce the microvascular complications of type 2 diabetes

REALIST is also evaluating the risk of microvascular complications in patients with type 2 diabetes who achieve or approach LDL-C goal. Data collected by Professor Michel Hermans from the Cliniques Universitaires Saint-Luc in Brussels, Belgium, were presented by Professor Paola Fioretto, from the Department of Medical and Surgical Sciences, University of Padua, Italy and showed that:

    - Low HDL-C, elevated TG and elevated non-HDL-C levels are more
      prevalent in patients who developed microvascular complications

    - High TG levels are associated with increased risk of incident
      retinopathy, blindness and diabetic kidney disease

    - Low HDL-C levels are associated with incident diabetic kidney
      disease

Similar to the findings of the macrovascular REALIST survey, the initial microvascular data showed that patients with incident microvascular complications of type 2 diabetes are more likely to present with atherogenic dyslipidemia even when LDL-C is nearly at goal (less than or equal to 130mg/dL).

"Further analysis of microvascular data from this and other centers should confirm the relationship between atherogenic dyslipidemia and microvascular complications of type 2 diabetes," said Professor Fioretto.

Implications of the R3i research program for future treatment

The REALIST research program is being globally extended and data are currently being collected in 27 centers in 12 countries around the world. This will support the major global program of education and advocacy being implemented by the R3i.

The ultimate objective of the R3i
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SOURCE Residual Risk Reduction Initiative Foundation
Copyright©2009 PR Newswire.
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