New insights into lipid-related macrovascular risk
Professor Gerd Assmann, member of the R3i International Steering Committee and President of the Board of the Assmann-Foundation for Prevention, presented a new analysis from PROCAM in which 823 men who survived a myocardial infarction (MI) were matched with an equal number of controls free from MI. This analysis, which was funded by the R3i, demonstrated:
- Low HDL-C and/or elevated triglycerides (TG) was seen in nearly two-thirds of MI patients - When all risks factors were matched, the odds of experiencing a MI were increased five-fold for men with LDL-C at target (less than or equal to 100mg/dL) presenting a low level of HDL-C (<45 mg/dL) and an elevated level of TG (>150 mg/dL)
The initial macrovascular findings of REALIST were also presented by Professor Frank Sacks, Vice-President of the R3i. This case-control study conducted in 170 patients hospitalized with CHD in Boston, USA, at goal for LDL-C, matched with 175 controls free from CHD shows that:
- High TG and low HDL-C are strong indicators of residual risk of CHD - High TG and low HDL-C levels each contribute to the risk of a coronary event in patients with LDL-C levels less than or equal to 130 mg/dL or even less than or equal to 70 mg/dL - TG and HDL-C appear to act synergistically with the impact of TG increasing when HDL-C is low and the impact of HDL-C increasing when TG levels are high
|SOURCE Residual Risk Reduction Initiative Foundation|
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