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New Independent Research Study Indicates That Cylex's ImmuKnow Test May Identify Kidney Transplant Patients at Risk for Early Acute Rejection
Date:2/20/2008

COLUMBIA, Md., Feb. 20 /PRNewswire/ -- Cylex, Inc., today announced the publication of an independent, peer reviewed, clinical research study in which the level of cellular immune response measured prior to kidney transplantation using the Company's proprietary ImmuKnow(R) immune cell function test was found to identify patients that may be at risk for early acute transplant rejection and unstable kidney function in the first three months following transplantation.

The results of this independent clinical research study, which was authored by members of the kidney transplant programs at Duke University Medical Center (Durham, NC), the University of Minnesota (Minneapolis, MN) and Cedars-Sinai Medical Center (Los Angeles, CA), appeared in an article published in the February 15, 2008 issue of the journal Transplantation.

"Based on our immunosuppression protocol, this study is the first to show that high pre-transplant ImmuKnow values identify recipients at risk for early acute rejection and unstable renal function," said Dr. Nancy L. Reinsmoen of Cedars-Sinai Medical Center and the lead author of the study. "No other innovative parameter we tested showed any such trends or associations."

This study of 126 kidney transplant patients was designed to evaluate the association of a number of immune parameters measured prior to kidney transplant with the occurrence of early acute rejection, unstable kidney function and graft outcome following transplantation. A statistically significant correlation was reported between high pre-transplant levels of cellular immune response, as measured using the ImmuKnow immune cell function test, and early acute transplant rejection as well as unstable kidney function within the first 90 days following kidney transplant.

The authors of the Transplantation article conclude that pre-transplant assessment of donor-specific and nonspecific immune parameters with ImmuKnow "may identify recipients who can bene
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SOURCE Cylex, Inc.
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