Navigation Links
New HIV vaccine approach targets desirable immune cells
Date:9/1/2011

DURHAM, N.C. Researchers at Duke University Medical Center, Beth Israel Deaconess Medical Center and Harvard Medical School have demonstrated an approach to HIV vaccine design that uses an altered form of HIV's outer coating or envelope protein.

The researchers showed that they could design HIV envelopes that could bind better to immature B cell receptors to create an enhanced immune response in an animal model. Immature B cells are the targets of vaccines, and when strongly targeted, they produce strong vaccine responses. The work of the Duke team was to improve on the ability of the HIV envelope to target immature B cells of the immune system.

"This is first step towards a new way of making vaccines against HIV: targeting immature immune cells and attempting to drive a pathway of events that rarely occur," said Barton Haynes, M.D., co-senior author and director of the national Center for HIV-AIDS Vaccine Immunology (CHAVI) laboratory and Frederic M. Hanes Professor of Medicine and Immunology at Duke University School of Medicine. "This avenue of research provides additional evidence about why some of the earlier, traditional vaccine approaches for HIV may not have been successful."

The study was published in the Sept. 1 issue of PLoS Pathogens.

Handcrafting vaccines that will stimulate different stages of the pathway toward immunity looks to be important, Haynes said. A vaccine usually uses a part of the virus (like part of its outer coating) or a harmless form of the virus to create a strong immune response against the virus.

This new work is the first time researchers have made an HIV envelope that binds better to precursor antibodies and also stimulates better immunity, compared with a natural envelope, in primates.

Hua-Xin Liao, M.D., Ph.D., a professor of medicine in the Duke Human Vaccine Institute (DHVI) and co-senior author, created the altered HIV outer coats. "Roadblocks thrown up by
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology technology :

1. GeoVax Awarded $3.6 Million Grant by U.S. Government for its HIV/AIDS Vaccine Program
2. Americans Travel to Mexico for Stem Cell Stimulation Therapies and E+ Peptide Cancer Vaccine -- Treatments Not Yet Offered in U.S.
3. Scientists take a step towards developing better vaccines for bluetongue
4. SEEK Announces Clinical Proof of Efficacy in HIV Vaccine Phase Ib/II Human Trial
5. Final countdown: Atlantis to carry next-generation vaccine candidate on last space voyage
6. Sorrento Therapeutics Innovative Approach to Developing Vaccines and Therapeutics for MRSA Receives Continued Support From the National Institute of Allergy and Infectious Diseases
7. New salmonella-based clean vaccines aid the fight against infectious disease
8. Inovio Pharmaceuticals DNA Vaccine for Foot-and-Mouth Disease Generates Protective Neutralizing Antibodies in Second Large-Animal Study
9. Inovio Pharmaceuticals Prostate Cancer DNA Vaccine Demonstrates Strong T Cell Responses in Monkeys; Company on Track for Phase I Clinical Trial
10. PharmAthene Achieves Anthrax Vaccine Program Milestone and Successfully Completes Technology Transfer
11. GeoVax Initiates Third Site For Therapeutic Testing of Its HIV Vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... Cambridge Healthtech Institute will host its fifth annual ... Renaissance Waterfront Hotel in Boston, MA. The ten ... the current strategies and innovations for optimizing bioprocesses while ... the field will reveal how their work has resulted ... and efficiency. , “In this age of rapid innovation, ...
(Date:5/16/2013)... , May 16, 2013  HealthSparq, a ... of the nation,s largest regional health plans, will ... Health Insurance Plans (AHIP) Institute 2013 conference on ... survey results showing how health insurance companies across ... the consumer and marketplace demands for increased healthcare ...
(Date:5/16/2013)... Scientists at the Center for Learning and ... the California -based biopharmaceutical company Magceutics, ... for reversing memory decline in mice with Alzheimer,s Disease. ... improvement in advanced stage AD mice. The study is ... decline for advanced stage AD mice, and is also ...
(Date:5/16/2013)... Toronto, Canada (PRWEB) May 16, 2013 ... years and costs over one billion dollars. Despite this ... market. With stakes this high, is your clinical trial ... and deliver the best outcomes? , Dr. Frederic Sax, ... Quintiles, will discuss the use of data, information and ...
Breaking Biology Technology:The 2013 Bioprocessing Summit to Bring Together International Leaders to Discuss Today's Bioprocess Issues From Cell Line Selection to Manufacturing in Boston, MA 2HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 2HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 3Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 3Optimizing Clinical Trials Outcomes through Computer Assisted Design, New Life Science Webinar Hosted by Xtalks 2
... , ... • Alexa Fluor • TAMRA • ... Flexible and scalable uHTS programs demand that organizations ... the task. This application note describes experiments to assess the performance of ...
... , ... fluorescent image analysis • IN Cell Analyzer • IN Cell Developer ... Neurite extension, or neurite outgrowth, plays a fundamental ... outgrowth is also critical in some neuropathological disorders as well as ...
... , ... CypHer ™ 5, a pH sensitive dye, has shown utility ... to obtain dose-response and rank-order potency data for both agonist ... live-cell receptor internalization studies, an enhanced version of this dye, ...
Cached Biology Technology:Performance of fluorescent dyes with LEADseeker Multimodality Imaging System 2Performance of fluorescent dyes with LEADseeker Multimodality Imaging System 3Neurite outgrowth cell-by-cell analysis using the IN Cell Developer Toolbox 2Neurite outgrowth cell-by-cell analysis using the IN Cell Developer Toolbox 3Neurite outgrowth cell-by-cell analysis using the IN Cell Developer Toolbox 4Neurite outgrowth cell-by-cell analysis using the IN Cell Developer Toolbox 5Neurite outgrowth cell-by-cell analysis using the IN Cell Developer Toolbox 6Screening for potential beta 2-adrenergic receptor antagonists using CypHer5E and IN Cell Analyzer 1000 2Screening for potential beta 2-adrenergic receptor antagonists using CypHer5E and IN Cell Analyzer 1000 3Screening for potential beta 2-adrenergic receptor antagonists using CypHer5E and IN Cell Analyzer 1000 4Screening for potential beta 2-adrenergic receptor antagonists using CypHer5E and IN Cell Analyzer 1000 5Screening for potential beta 2-adrenergic receptor antagonists using CypHer5E and IN Cell Analyzer 1000 6
(Date:5/17/2013)... of all ages will celebrate the science and ... our daily lives during the inaugural Atlanta Science ... educators from local museums, corporations, K-12 schools and ... different events for children and adults at venues ... . , The annual Atlanta Science Festival ...
(Date:5/17/2013)... iCargo project (Intelligent Cargo in Efficient and Sustainable Global ... to an improvement in the efficiency of intermodal loading ... decision making. It comprises 29 European organisations with experience ... It has a budget totalling 17,000,000 and a duration ... working to specify and develop the semantic components and ...
(Date:5/17/2013)... An international team of scientists using a new ... inside a living frog embryo in greater detail than ... advance biological research and the search for new treatments ... Karlsruher Institut fr Technologie in Germany, in collaboration with ... Energy,s Argonne National Laboratory, released the most precise depiction ...
Breaking Biology News(10 mins):First Atlanta Science Festival set for 2014 2New logistics services that will cut energy consumption and CO2 emissions 2New X-ray method shows how frog embryos could help thwart disease 2
... a small amount of carbon nanotubes can go a ... of plastic materials widely used in engineering applications, according ... Institute have developed a simple new technique for identifying ... wings and many other structures made from polymer composites. ...
... 2007 -- An international collaboration directed by an ... first-ever atomic-detail computer simulation of how proteins vibrate ... ORNL,s Center for Molecular Biophysics, said experimental testing ... of the Office of Science,s recently completed Spallation ...
... might affect the type and evolution of toxins in their ... Evolutionary Biology shows. In snakes, venom composition varies ... feed on a range of animals and birds, so scientists ... in their venom. Sea snakes, on the other hand, tend ...
Cached Biology News:Using nanotubes to detect and repair cracks in aircraft wings, other structures 2Using nanotubes to detect and repair cracks in aircraft wings, other structures 3Using nanotubes to detect and repair cracks in aircraft wings, other structures 4Interacting protein theory awaits test from new neutron analysis tools 2
Recombinant Feline IL-5...
dithiothreitol (DTT) Reactive Dyes and Chemicals Thiol-Reactive Dyes, Haptens and Quenchers Reducing Agents...
Recombinant Feline IL-2, CF...
Recombinant Equine IL-4, CF...
Biology Products: