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New HIV prevention technology shows promise
Date:10/25/2012

ARLINGTON, VA -- CONRAD researchers, in collaboration with engineers at the University of Utah, have designed a 90-day intravaginal ring that can be used by women to prevent the sexual transmission of HIV. A study of the ring used sheep to determine whether safe, effective and steady doses of the antiretroviral drug tenofovir can be released over 90 days. This research is being presented at the 2012 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in Chicago, Ill., Oct. 14 18 and will be published in the 12th issue of Antimicrobial Agents and Chemotherapy.

Tenofovir is a drug commonly used by those infected with HIV to prevent the virus from multiplying in the immune system. A clinical study of women in South Africa who used a vaginal gel containing tenofovir has shown that it is almost 40 percent effective in reducing sexual transmission when used before and after sex, and 54% effective if used with every act of intercourse.

"We have developed a new intravaginal ring technology based on rubbery hydrogel plastics that are loaded with antiretroviral drugs. We can engineer the plastic so it can release a small quantity of drug per day, or a much larger quantity, depending on the drug being delivered," said Patrick Kiser, Ph.D, the lead investigator at the University of Utah.

Vaginal rings have been used since the 1970s, and the possibility for reducing HIV infection has caused a burst of innovation in the field, using new materials and technologies.

"Most vaginal rings release a limited quantity of drug each day, but this ring can release quantities 1,000 times larger due to the selection of specific hydrophilic polymers with high permeability," said David Friend, Ph.D., director of Product Development at CONRAD, who is also an author on the work. "This study showed that the ring releases at least 10 mg of tenofovir a day over 90 days, which makes it very possible that it can
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Contact: Annette Larkin
larkinannette@yahoo.com
703-772-6427
CONRAD
Source:Eurekalert

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