Navigation Links
New HIV prevention technology shows promise
Date:10/25/2012

ARLINGTON, VA -- CONRAD researchers, in collaboration with engineers at the University of Utah, have designed a 90-day intravaginal ring that can be used by women to prevent the sexual transmission of HIV. A study of the ring used sheep to determine whether safe, effective and steady doses of the antiretroviral drug tenofovir can be released over 90 days. This research is being presented at the 2012 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in Chicago, Ill., Oct. 14 18 and will be published in the 12th issue of Antimicrobial Agents and Chemotherapy.

Tenofovir is a drug commonly used by those infected with HIV to prevent the virus from multiplying in the immune system. A clinical study of women in South Africa who used a vaginal gel containing tenofovir has shown that it is almost 40 percent effective in reducing sexual transmission when used before and after sex, and 54% effective if used with every act of intercourse.

"We have developed a new intravaginal ring technology based on rubbery hydrogel plastics that are loaded with antiretroviral drugs. We can engineer the plastic so it can release a small quantity of drug per day, or a much larger quantity, depending on the drug being delivered," said Patrick Kiser, Ph.D, the lead investigator at the University of Utah.

Vaginal rings have been used since the 1970s, and the possibility for reducing HIV infection has caused a burst of innovation in the field, using new materials and technologies.

"Most vaginal rings release a limited quantity of drug each day, but this ring can release quantities 1,000 times larger due to the selection of specific hydrophilic polymers with high permeability," said David Friend, Ph.D., director of Product Development at CONRAD, who is also an author on the work. "This study showed that the ring releases at least 10 mg of tenofovir a day over 90 days, which makes it very possible that it can be effective in preventing HIV infection in women."

An intravaginal ring that can be worn for 90 days is crucial for adherence, as well as cost in low-income countries. Drugs are only effective when actually used as prescribed, and in the case of a ring containing an active drug that is inserted for 90 days, the problem of adherence is significantly reduced, at least for that time period.

The intravaginal ring used in the study is made from rubbery water swellable plastics that can be processed using techniques developed in the medical device industry. The tubing consists of plastic which is filled with a paste of tenofovir and glycerin. The tube is sealed shut and joined into a ring shape. The glycerol in the core brings fluid from the vagina that accelerates the drug delivery process.

"We directly compared the ring to 1 percent tenofovir gel, and the ring resulted in similar, if not higher, levels of drug in the vaginal tissue," said Dr. Friend. "If the results in sheep hold up in humans, we would expect this ring to be highly protective against HIV."

Gustavo Doncel, MD, Ph.D, executive director of CONRAD and a coauthor of the study said, "We are very excited about this new, improved delivery system for tenofovir, the only microbicide with proof of efficacy in animals and humans, and are working hard to move this product into the first clinical trial of a tenofovir ring next year."

Drs. Kiser and Friend conducted the study with colleagues at CONRAD including Meredith Clark, Ph.D, Dr. Doncel, and Neelima Chandra, PhD.; and graduate students Todd Johnson and Justin Clark; and undergraduate Ted Albright. This work was part of Johnson's Ph.D. thesis. The study was funded by USAID through a grant to CONRAD.


'/>"/>

Contact: Annette Larkin
larkinannette@yahoo.com
703-772-6427
CONRAD
Source:Eurekalert

Related biology technology :

1. Arteriocyte Receives FDA Approval to Initiate Compartment Syndrome Trial for Amputation Prevention Focused on Wounded Warriors
2. Preclinical data shows 100 percent prevention and treatment of influenza with engineered human antibody
3. Bayer HealthCares Cotavance® Drug Eluting Balloon With Paccocath® Technology Reduced Five-Year Target Lesion Revascularization Rates by 59 Percent in PAD Patients Compared to Those Treated With Uncoated Balloon
4. Positive Clinical Study Results for BSPs HyperQ Technology
5. Arizona State University engineers aim to improve performance of technology in extreme environments
6. iBioLaunch™ Technology Successfully Applied to Modified C1 Inhibitor
7. Pitt discoveries in quantum physics could change face of technology
8. Verenium to Present at Baird Clean Technology Conference
9. Puma Biotechnology Announces Completion of Private Placement
10. Roche NimbleGen and BGI Develop Advanced MHC Region Capture Technology for Human Disease and Biomedical Research
11. Animal Biotechnology - Technologies, Markets and Companies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
(Date:6/23/2016)... On Wednesday, June 22, 2016, the ... the Dow Jones Industrial Average edged 0.27% lower to finish ... 0.17%. Stock-Callers.com has initiated coverage on the following equities: Infinity ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... ). Learn more about these stocks by accessing their free ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, a division ... tuned and optimized exclusively for Okuma CNC machining centers at The International Manufacturing ... collaboration among several companies with expertise in toolholding, cutting tools, machining dynamics and ...
(Date:6/22/2016)... Cell Applications, Inc. and StemoniX announced ... up to one billion human induced pluripotent stem ... These high-quality, consistent stem cells enable researchers to ... more time doing meaningful, relevant research. This achievement ... process that produces affordable, reliable HiPSC for life ...
Breaking Biology Technology:
(Date:5/16/2016)... NEW YORK , May 16, 2016   ... authentication solutions, today announced the opening of an IoT ... to strengthen and expand the development of embedded ... provides an unprecedented level of convenience and security with ... to authenticate one,s identity aside from DNA. EyeLock,s platform ...
(Date:4/28/2016)... FRANCISCO and BANGALORE, India , ... of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... provider, today announced a global partnership that will ... way to use mobile banking and payment services. ... is a key innovation area for financial services, but it ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
Breaking Biology News(10 mins):