Navigation Links
New Genotyping System Identifies Pathogenic E. coli Outbreak Strains
Date:5/21/2013

WOBURN, MA (PRWEB) May 21, 2013

PathoGenetix, Inc., a commercial-stage developer of an automated system for rapid bacterial strain typing, announced today that it has successfully identified and strain typed a collection of 250 pathogenic E. coli strains obtained from the Centers for Disease Control and Prevention (CDC) using the company’s Genome Sequence Scanning™ (GSS™) technology. The findings are detailed in a poster presented at the General Meeting of the American Society for Microbiology in Denver on Monday.

The 250 E. coli strains, which included the most frequently isolated STEC (Shiga toxin-producing E. coli) serotypes from both sporadic cases and multiple foodborne illness outbreaks, were run on the company’s prototype Genome Sequence Scanning system. The results showed that the system could be used to reliably differentiate and strain type STECs of public health and food safety significance, and aid in epidemiological investigation and response in foodborne illness outbreaks.

The GSS-generated phylogenetic tree clearly delineated the major STEC serotypes, and generally clustered the 250 strains into their appropriate serotype-specific branches. Strains that originated from the same foodborne illness outbreak also clustered together on the phylogenetic tree, demonstrating the system’s ability to differentiate outbreak clusters from each other and from epidemiologically unrelated strains. The strain information provided by GSS was comparable to pulsed field gel electrophoresis (PFGE), the current standard for pathogen typing in foodborne illness outbreak investigation and response.

Genome Sequence Scanning isolates and analyzes genomic DNA from either a complex mixture or a pure culture, provides strain type information and predicts the bacterial serotype in five hours, days faster than current identification methods. The GSS technology will be commercially available in 2014 in PathoGenetix’s RESOLUTION™ Microbial Genotyping System.

Of the numerous types of bacteria categorized as Escherichia coli, or E. coli, some cause disease by producing a toxin called Shiga toxin. Since 1993, when four children died and more than 700 people were infected with E. coli O157:H7 in ground beef, there has been an increasing focus on these “Shiga toxin-producing” E. coli (or STECs) in public health, food safety and regulatory efforts. The CDC lists E. coli STEC O157 in the top five pathogens contributing to domestically acquired foodborne illnesses resulting in hospitalization, estimating that it is responsible for 2,138 hospitalizations each year.

In the past 10 years, other E. coli STEC serotypes have been identified in major outbreaks, as dramatically illustrated in Germany in 2011 when more than 4,000 people became ill and 50 people died due to E. coli O104:H4. In 2012, six additional strains of Shiga toxin-producing E. coli (STECs O26, O45, O103, O111, O121 and O145) were declared adulterants by the U.S. Department of Agriculture Food Safety and Inspection Service (USDA-FSIS), which plans to expand testing for these “Big 6” non-O157 strains next year. Although beef remains the most common source, STECs have been linked to major recalls in numerous other foods including spinach, lettuce, cucumbers, peppers, sprouts and currently, frozen foods.

***

About PathoGenetix, Inc.

PathoGenetix, Inc. is a commercial-stage developer of an automated system for rapid bacterial identification from complex samples. PathoGenetix is a venture-backed company that has received more than $50 million in technology development funding from the Department of Homeland Security. The core GSS technology isolates and analyzes DNA directly from an enriched biological sample—without the need for a cultured isolate—and provides results in just five hours, days faster than current methods. GSS has broad applicability in food safety, industrial microbiology, and clinical diagnostics and research. The first commercial GSS system will be available in 2014 for use in food safety testing and foodborne illness outbreak investigations. Learn more at http://www.pathogenetix.com.

Read the full story at http://www.prweb.com/releases/bacterial_identification/pathogenic_e_coli/prweb10752044.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. PathoGenetix Advances Commercialization of New RESOLUTION Microbial Genotyping System for Rapid Bacterial Serotyping and Strain Typing
2. Researchers identify signals that direct the immune system to reject a transplanted organ
3. INTIO Introduces TipTRAC™, its Newest Feature for its ClearStart SVM™ Intraoperative Imaging System
4. Real Time Genomics and Knome Ink Deal to Integrate and Sell the RTG Variant Platform on knoSYS100 System
5. Leviticus Cardio Ltd. Completes a Successful Animal Trial for its Wireless Energy System for VADs
6. Leica Microsystems Debuts First 3D Surgical Microscopes with TrueVision® Technology Inside, at AANS Annual Meeting in New Orleans
7. Magnetic Resonance Imaging (MRI) System Market worth $5.24 Billion By 2018
8. PathoGenetix and FDA to Evaluate Bacterial Identification System for Use in FDA Public Health and Food Safety Efforts
9. Used-Line.com's Automated ‘Wanted-List System’ Matches Test Equipment Wanted Lists with Dealer Inventory; Beta Version Open for All Test Equipment Dealers
10. mPhase Technologies, Inc. Commencing Discussions with Major European Drug Company for Drug Delivery System
11. The SDS/MSA Support Group Officially Changes Name to The Multiple System Atrophy Coalition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... 24, 2016 Epic Sciences unveiled a ... susceptible to PARP inhibitors by targeting homologous recombination ... The new test has already been incorporated into ... cancer types. Over 230 clinical trials ... pathways, including PARP, ATM, ATR, DNA-PK and WEE-1. ...
(Date:6/23/2016)... ... 23, 2016 , ... Mosio, a leader in clinical research ... Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the ... tools, and strategies for clinical researchers. , “The landscape of how patients receive ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... MA (PRWEB) , ... June 23, 2016 , ... ... Peel Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute ... platform of microbial tests introduced last year,” stated Bob Salter, Vice President of ...
Breaking Biology Technology:
(Date:6/27/2016)... -- Research and Markets has announced the addition of ... their offering. The report forecasts ... grow at a CAGR of 12.28% during the period 2016-2020. ... market analysis with inputs from industry experts. The report covers the ... report also includes a discussion of the key vendors operating in ...
(Date:6/22/2016)... 22, 2016  The American College of Medical Genetics and ... Magazine as one of the fastest-growing trade shows during ... the Bellagio in Las Vegas . ... of growth in each of the following categories: net square ... number of attendees. The 2015 ACMG Annual Meeting was ranked ...
(Date:6/22/2016)... ANGELES , June 22, 2016 /PRNewswire/ ... identity management and verification solutions, has partnered ... edge software solutions for Visitor Management, Self-Service ... provides products that add functional enhancements ... partnership provides corporations and venues with an ...
Breaking Biology News(10 mins):