Navigation Links
New Drugs for Atrial Fibrillation Represent Choices for Clinicians, Opportunities for Generics
Date:12/4/2013

Amherst, NH (PRWEB) December 04, 2013

The availability of a new class of anticoagulants is providing cardiologists with a new set of tools for treating a refractory indication. Atrial fibrillation (AF) represents a growing clinical challenge for healthcare practitioners, due primarily to a set of diverse causative factors and to the secondary nature of AF. Often classified as either valvular or nonvalvular, AF increases the risk of stroke. The degree of increase can be substantial, depending on the presence of additional risk factors (such as high blood pressure). Atrial fibrillation may be treated with medications to either slow the heart rate to a normal range (rate control) or revert the heart rhythm to normal (rhythm control). The prevalence of AF in a population increases with age, with 8% of people over 80 having AF.

Drugs known as novel oral anticoagulants (NOACs) are providing clinicians with a new set of tools to treat patients with AF. NOACs are more convenient, and are considered to be at least equally effective and safer (regarding bleeding complications) for stroke prevention compared with vitamin K antagonists. Drugs in this group include Eliquis (apixaban, BMS), Pradaxa (dabigaran etexilate, Boehringer Ingelheim), and Xarelto (rivaroxiban, Janssen). Together, these three drugs had revenue of $2.3 billion in 2012 (ex-manufacturer basis).

While Pradaxa established the early lead in this market segment, Xarelto and Eliquis have been expected to make gains and win market share over the next three years. Clinical trial results indicated that Eliquis would have an advantage over Xarelto, but since the latter’s FDA approval it has been Xarelto that has made a significant impact, with total expected revenue for 2013 easily exceeding one billion dollars. Meanwhile, Eliquis has struggled, with sales for 2013 well below company and analyst forecasts.

All three drugs have been granted exclusivity by the FDA, with expiration dates that fall in 2015-2017. We expect all three to come under pressure from generics companies during that time frame, with ANDAs likely being disclosed over the next eighteen months. Eliquis has an advantage here, with exclusivity expiring at the tail end of 2017. But BMS will have to find a way to accelerate sales growth in order to maximize its investment in the drug prior to generic market entry. We expect the likely appearance of a first-to-file generic version of Eliquis in 2018 to result in a 37% drop in revenue for the year, relative to our baseline (no early generic entry) forecast for Eliquis.

More information is available at Symporia.com.

About Symporia Bioscience

Symporia Bioscience analyzes generic drug markets, publishing generic drug First-to-File Opportunity Assessments, which are designed to allow industry managers to understand and evaluate the market potential for selected branded drugs from the viewpoint of creating and refining FDA ANDA regulatory filings in pursuit of first-filer generic drug applications. By applying predictive analytics to known drug market data, generic drug first-to-file opportunity assessments provide a unique view into the evolving generics drug sector. The publications represent detailed assessments of selected branded drugs in several important areas. The resulting conclusions are contained in written reports that are structured to provide timely insight to market participants.

Read the full story at http://www.prweb.com/releases/2013/12/prweb11384170.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. Enteris BioPharma Forms Scientific Advisory Board to Enhance Leadership in Oral Delivery of Peptide and Small Molecule Drugs
2. Biohack Pure’s Jonathan Weisman Predicts the Future of Smart Drugs
3. Tricking algaes biological clock boosts production of drugs, biofuels
4. Novogen Launches Joint Venture Aimed At Developing Drugs to Fight Ovarian Cancer
5. In The Face Of Increasing Healthcare Spend And High-Cost Targeted Treatment, Market Access Barriers Continue To Rise For Targeted Oncology Drugs
6. Legislative Benefits and Unmet Needs to Drive the Market for Orphan Drugs, According to a New Report by Global Industry Analysts, Inc.
7. Spartan Bioscience Receives FDA Clearance for First Rapid DNA Test of Mutations Affecting Metabolism of Common Drugs
8. Neuroprotection - Drugs, Markets and Companies - Updated 2013 Report with Extra Company Collaborations
9. Stem Cells Might Beat Drugs in Delivering Relief Faster, More Effectively to Rheumatoid Arthritis Sufferers
10. Currently approved drugs found effective in laboratory mice against bioterror threats
11. Alzheimer Disease - New Drugs, Markets and Companies - 2013
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator ... Members of the Class of 2016 were selected from a pool of 128 ... About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, ... of the Supplyframe Design Lab . Located in Pasadena, Calif., the Design ... of how hardware projects are designed, built and brought to market. , The ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... -- On Wednesday, June 22, 2016, the NASDAQ ... Dow Jones Industrial Average edged 0.27% lower to finish at ... Stock-Callers.com has initiated coverage on the following equities: Infinity Pharmaceuticals ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ... Learn more about these stocks by accessing their free trade ...
Breaking Biology Technology:
(Date:3/23/2016)... , March 23, 2016 ... erhöhter Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender ... das Unternehmen mit SpeechPro zusammenarbeitet, um erstmals ... Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im Rahmen ...
(Date:3/22/2016)... OTTAWA, Ontario , PROVO ... 2016 Newborn Screening Ontario (NSO), which operates ... for molecular testing, and Tute Genomics and ... process management technology respectively, today announced the launch of ... new next-generation sequencing (NGS) testing panel. ...
(Date:3/18/2016)... , March 18, 2016 ... Suppliers of Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure ... & security companies in the border security market and the ... and Europe has led visiongain ... companies improved success. --> defence & security ...
Breaking Biology News(10 mins):