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New Data Suggest Veracyte's Afirma® Gene Expression Classifier Cost-Effectively Resolves Inconclusive Thyroid Nodule FNA Biopsy Results
Date:9/1/2011

assifier, which classifies as benign or suspicious for malignancy those thyroid nodule FNA samples deemed indeterminate by cytology. The analysis did not include indirect costs, such as time lost at work, decreased productivity or money spent on healthcare outside of the medical setting.

In addition to reducing the number of surgeries on patients with benign nodules, the authors found that routine use of the Afirma Gene Expression Classifier on indeterminate cases increased to 54% the likelihood that patients who go to surgery will actually prove to have cancer, from 35% using current practice. There was no increase in missed cancers using the gene expression test.

"These findings add to the evidence demonstrating that our Afirma Gene Expression Classifier can enable doctors to make better and more efficient treatment decisions that improve care for thyroid patients and provide cost savings to the healthcare system," said Bonnie Anderson, Veracyte's cofounder and chief executive officer. "We look forward to continuing to make our test available to doctors and their patients across the country."

The Afirma Gene Expression Classifier is part of Veracyte's Afirma Thyroid FNA Analysis, a novel solution for improved accuracy in thyroid nodule diagnosis. This comprehensive approach combines expert cytopathology assessment along with the company's genomic test, which clarifies as either benign or suspicious for cancer those thyroid nodule FNA results initially deemed indeterminate by cytopathology. Previous multicenter studies have shown the test to have a negative predictive value of greater than 95%. Veracyte began making its solution available earlier this year to endocrinologists around the country.

Thyroid cancer is the fastest-growing cancer in the U.S., with an estimated 44,670 new cases per year. Thyroid FNAs, a procedure conducted in the doctor's office in which a needle is inserted into the suspicious nodule to extract cells for exa
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