Navigation Links
New Data Presented on Immunocytokine Fusion Protein Further Supports Broad Anti-Cancer Potential Of Peregrine's Anti-PS Technology Platform
Date:10/5/2007

- Immunocytokine Combining Peregrine's Anti-PS Antibodies and IL-2 Protected 80% of Animals From a Lethal Challenge With a Highly Aggressive Form of Breast

Cancer -

- New Data Presented at International Conference on Vascular Targeted Therapies in Oncology Further Supports a Second Mechanism of Action for

Anti-PS Antibodies -

MANDELIEU, France and TUSTIN, Calif., Oct. 5 /PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a clinical stage biopharmaceutical company developing targeted therapeutics for the treatment of cancer and hepatitis C virus infections, today reported that data presented at the International Conference on Vascular Targeted Therapies in Oncology showed that a fusion protein combining interleukin-2 (IL-2) and 2aG4, an anti-phosphatidylserine (anti-PS) antibody similar to Peregrine's bavituximab, was effective in stimulating a strong protective immune response when added to a cancer vaccine. The combination was effective in protecting animals against a lethal challenge with a highly aggressive form of breast cancer. The new data is being presented by Dr. Philip Thorpe, professor of pharmacology at UT Southwestern Medical Center in Dallas and a member of the Peregrine Scientific Resource Board.

In the study reported today, breast cancer cells were irradiated to inactivate them and to expose the anti-PS target on their surface. The irradiated cancer cells were then treated with the 2aG4-IL-2 fusion protein to increase their immunogenicity before being used to vaccinate the study animals. Eighty percent of the immunized mice survived a subsequent lethal challenge with live versions of these aggressive breast cancer cells. In contrast, no animals immunized with untreated irradiated breast cancer cells survived the subsequent lethal challenge.

"We are encouraged by the results of this study in a very challenging model of breast cancer that further support the broad potential of our anti-PS targeting platform," said Dr. Thorpe. "In view of these results, we are eager to learn more about the anti-cancer utility of these immunocytokine fusion proteins in combination with vaccines and as direct therapeutic agents."

The results of this study also suggest that anti-PS antibodies may be stimulating the immune system by a second mechanism. Phosphatidylserine that has become exposed on the external surface of cells has been shown to dampen the body's natural immune response. Researchers have demonstrated that anti-PS antibodies can block this immune-suppressing signal by binding to and neutralizing the exposed phosphatidylserine, allowing the immune system to mount a more vigorous response.

"This data further supports the broad potential of our anti-PS platform, building on earlier data demonstrating that anti-PS antibodies have the ability to recognize tumors and then initiate a robust immune response," said Steven W. King, president and CEO of Peregrine. "Previously we reported that our fusion proteins demonstrated excellent anti-tumor activity in a number of cancer models as a therapeutic agent. This new research shows that these same agents also have the potential to enhance cancer vaccines, priming the body's immune system to prevent the development of cancer in animals challenged with a normally lethal dose of cancer cells by enhancing the immune response to the tumor."

The new class of immunocytokine fusion protein agents is part of Peregrine's Vascular Targeting Agent (VTA) technology platform for cancer therapy that includes over 200 patents and patent applications covering broad concepts of tumor therapy using agents that target tumor blood vessels.

This study, "Enhancement of Tumor Immunogenicity by 2aG4-IL2 Fusion Protein," was conducted by Dr, Xianming Huang, assistant professor of pharmacology in the laboratory of Dr. Philip Thorpe. Study results are being presented by Dr. Thorpe at the International Conference on Vascular Targeted Therapies in Oncology, Mandelieu, France, October 5th, 2007 at 3:10pm local time (9:10am ET).

About Peregrine Pharmaceuticals

Peregrine Pharmaceuticals, Inc. is a biopharmaceutical company with a portfolio of innovative product candidates in clinical trials for the treatment of cancer and hepatitis C virus (HCV) infection. The company is pursuing three separate clinical programs in cancer and HCV infection in the U.S. and India with its lead product candidates bavituximab and Cotara(R). Peregrine also has in-house manufacturing capabilities through its wholly owned subsidiary Avid Bioservices, Inc. (http://www.avidbio.com), which provides development and bio-manufacturing services for both Peregrine and outside customers. Additional information about Peregrine can be found at http://www.peregrineinc.com.

Safe Harbor Statement: Statements in this press release which are not purely historical, including statements regarding Peregrine Pharmaceuticals' intentions, hopes, beliefs, expectations, representations, projections, plans or predictions of the future are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. The forward-looking statements involve risks and uncertainties including, but not limited to, the risk that results of human studies will not correlate to the results achieved in connection with this preclinical breast cancer animal model, and the uncertainty as to whether the results of future clinical studies will support moving this product candidate forward for the treatment of breast cancer. It is important to note that the Company's actual results could differ materially from those in any such forward-looking statements. Factors that could cause actual results to differ materially include, but are not limited to, uncertainties associated with completing preclinical and clinical trials for our technologies; the early stage of product development; the significant costs to develop our products as all of our products are currently in development, preclinical studies or clinical trials; obtaining additional financing to support our operations and the development of our products; obtaining regulatory approval for our technologies; anticipated timing of regulatory filings and the potential success in gaining regulatory approval and complying with governmental regulations applicable to our business. Our business could be affected by a number of other factors, including the risk factors listed from time to time in the Company's SEC reports including, but not limited to, the annual report on Form 10-K for the year ended April 30, 2007 and the quarterly report on Form 10-Q for the quarter ended July 31, 2007. The Company cautions investors not to place undue reliance on the forward-looking statements contained in this press release. Peregrine Pharmaceuticals, Inc. disclaims any obligation, and does not undertake to update or revise any forward-looking statements in this press release.

Contacts:

GendeLLindheim BioCom Partners

Investors Media

info@peregrineinc.com Jennifer Anderson

(800) 987-8256 (212) 918-4642


'/>"/>
SOURCE Peregrine Pharmaceuticals
Copyright©2007 PR Newswire.
All rights reserved

Related biology technology :

1. Wisconsin Assembly passes capital investment bill, revised CAPCO program not presented
2. Simple, Sensitive, and Rapid Detection of FLAG -Tagged Fusion Proteins
3. Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion Transactivators
4. Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini
5. New Fusion Trans-Activator Plasmids for Studying Signal Transduction Pathways
6. Principles and applications of electrical cell fusion
7. Principles and applications of electrical cell fusion
8. Production of Hybridomas by Electrofusion
9. Monitoring fluorescence resonance energy transfer (FRET) between GFP fusions in lysates of the yeast Saccharomyces cerevisiae using the Varian Cary Eclipse
10. Comparison of Performance between the AlphaQuest - HTS and the Fusion α Multilabel Reader for Detection of cAMP
11. Mobile Phase Optimization for the Analysis of an Antibody-Based Fusion Protein and Aggregates using a TSKgel Super SW3000 Size-Exclusion Column
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... , Feb. 8, 2016  CytRx Corporation ... development company specializing in oncology, today announced that ... security agreement with Hercules Technology Growth Capital, Inc. ... $40 million in financing. --> ... first $25 million of financing under the loan ...
(Date:2/8/2016)... 2016  BioElectronics Corporation (OTC Pink: BIEL), the ... that it is responding to a notice of ... and Exchange Commission posted on the agency website.  ... the Board of BioElectronics Corporation and the Edward ... The Fuqua School of Business, Duke University.   ...
(Date:2/8/2016)... Feb. 8, 2016  NanoViricides, Inc. (NYSE MKT: NNVC) (the "Company"), ... Eugene Seymour , MD, MPH, will present information about the company,s ... Hotel in New York City . ... the Windsor Room at 5:30PM EST. Registered attendees can request a ... York City . --> New York ...
(Date:2/6/2016)... ... 06, 2016 , ... The Center for Excellence in Education (CEE) will sponsor ... on Wednesday February 10, 2016. This Bite of Science session, hosted by the ... at 1500 Remount Road in Front Royal, VA from 5:00 p.m. to 8:00 p.m. ...
Breaking Biology Technology:
(Date:2/9/2016)... 2016 Vigilant Solutions announces today that an agency ... develop a lead in a difficult homicide case. The agency ... locate the suspect vehicle. Due to the ongoing investigation, the ... omitted at the agency,s request. --> ... victim was found deceased at an intersection here in the ...
(Date:2/3/2016)... GOTHENBURG, Sweden , February 4, 2016 ... Revenues amounted to SEK 1,351.5 M (105.0), up 1,187% compared with fourth ... Operating profit amounted to SEK 517.6 M (loss: 30.0). Earnings ... from operating activities was SEK 537.4 M (neg: 74.7). , ... , Revenues amounted to SEK 2,900.5 M (233.6), up 1,142% ...
(Date:2/2/2016)... NEW YORK , Feb. 2, 2016 ... healthcare facilities are primarily focused on medical ... that measure point-of-care parameters. Wearable devices that ... a user,s freedom of movement are being ... sensors for human biomedical signal acquisition coupled ...
Breaking Biology News(10 mins):