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New Data Confirms the Negative Impact of Febrile Neutropenia in Patients With Non-Hodgkin Lymphoma Receiving R-CHOP Chemotherapy
Date:6/13/2010

s an abnormally low level of neutrophils, an important infection-fighting white blood cell (WBC), in the blood stream.  A low white blood cell count indicates that the immune system is not as strong as it should be, and the risk for serious infection is increased.(iv)

FN is a common and potentially dangerous side effect of myelosuppressive chemotherapy leading to a heightened risk of infection, sometimes life-threatening, among people with cancer. Severe neutropenia and/or FN may lead physicians to delay the next cycle of chemotherapy or reduce the dose given (in order to reduce further toxicity).

About G-CSFs

Granulocyte-colony stimulating factors (G-CSFs) are haematopoetic growth factors. It stimulates the bone marrow to produce more white blood cells. A major side effect of chemotherapy is the reduction in white blood cells which makes the body less able to combat infection. The use of a G-CSF after chemotherapy reduces the risk to patients of developing febrile neutropenia and reduces the duration of neutropenia.(v)

For further information please refer to the SmPC for pegfilgrastim and filgrastim – two commonly used G-CSFs.

About Amgen

Amgen discovers, develops and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realise the new science's promise by bringing safe and effective medicines from lab, to manufacturing plant, to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid arthritis, and other serious illnesses. With a deep and broad pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people's lives. To learn more a
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