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New Data Confirms the Negative Impact of Febrile Neutropenia in Patients With Non-Hodgkin Lymphoma Receiving R-CHOP Chemotherapy
Date:6/13/2010

CHOP-21 chemotherapy between 2005 and 2008. Centres were based in Europe (123 sites) and Australia (5 sites), with each enrolling up to 30 patients. Participating centres recorded their assessment of patients' FN risk, G-CSF use and FN incidence, as well as related outcomes such as chemotherapy delivery and unplanned hospitalisations. This current analysis is based on data from 1,111 patients with diffuse large B cell lymphoma.

G-CSFs are indicated to shorten the duration of severe neutropenia and reduce the incidence of FN.

About CHOP Chemotherapy

CHOP chemotherapy is named after the initials of the drugs used in the chemotherapy treatment. The drugs include cyclophosphamide, doxorubicin (chemical name hydoxydaunorubicin), vincristine (used to be called Oncovin®) and prednisolone, which is a steroid.(iii)

CHOP is given by a combination of injections into the tubing of a drip (infusion).The prednisolone is taken as tablets. In some instances CHOP chemotherapy may also be administered in combination with the monoclonal antibody rituximab (R-CHOP).

About FN

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SOURCE Amgen
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