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New Cancer Treatments and Combination Therapies Presented by Leading Experts from the John Theurer Cancer Center at the American Society of Clinical Oncology Annual Meeting
Date:6/3/2010

treated with rituximab plus a combination of doxorubicin, cyclophosphamide, vincristine, and dexamethasone (R-HCVAD); high-dose chemotherapy followed by autologous stem cell transplantation; and standard-dose chemotherapy with rituximab. Patients treated with either R-HCVAD or stem-cell transplantation had better survival rates than the patients treated with standard-dose chemotherapy and rituximab.

The researchers concluded that both R-HCVAD and high-dose chemotherapy combined with autologous stem cell transplantation provide a platform for treatment strategies that integrate novel therapies, or as part of a maintenance strategy.

Is the Mantle Cell Lymphoma International Prognostic Index (MIPI) adequate to stage this cancer? (Abstract number 8092; poster session, June 5, 8:00 a.m.12:00 p.m.)

In this study, Anthony Mato, M.D., Attending, Lymphoma, the John Theurer Cancer Center and his colleagues looked at the usefulness of a tool known as the Mantle Cell Lymphoma International Prognostic Index (MIPI) for guiding treatment strategies for mantle cell lymphoma, a difficult-to-treat non-Hodgkin lymphoma.  The index is used to classify patients into "low," "intermediate" and "high" risk groups in order to stage the cancer and determine the best treatment strategy.  Although MIPI has been validated in other studies, conflicting results on using MIPI to guide an aggressive therapy known as "HCVAD" led the researchers to investigate further. They conducted a single-center, retrospective cohort study to identify predictors of survival in patients treated with first-line rituximab-plus-HCVAD (R-HCVAD), alternating with rituximab-methotrexate-AraC (R-MTX-AraC), another combination therapy.

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