Navigation Links
New Biomarkers Study Could Lead to Better Malaria Vaccine Design
Date:4/27/2011

d scientists have developed genetically attenuated whole parasite vaccine strains that have proven successful in rodent malaria models and have moved into human studies. "In this new study, we will use genetically attenuated parasite strains as probes to determine whether host correlates of immunity can be identified during vaccination in mice," Kappe explained. "These model vaccines provide an opportunity to discriminate biomarkers associated with complete, long-lasting protection from those associated with partial, short-lived or lack of protection."

Researchers at Seattle BioMed will then apply the knowledge gained in mouse models to human studies. "Through studies conducted at Seattle BioMed's Malaria Clinical Trials Center, we'll evaluate whether biomarkers of protection identified in the rodent models will predict protective immunity in humans," explained Wang.

Applying Aderem's expertise in the field of systems biology to malaria research will be a key component of this project. Seattle BioMed researchers will employ network analysis of transcriptional responses to predict protection in both mice and humans to determine if they can find universal markers that will allow them to optimize vaccine candidates. According to Aderem, the power of systems biology lies in its capacity to predict the behavior of a biological system.  "If we have the ability to predict whether a vaccine candidate for malaria will work before it goes into large scale clinical trials, we could move away from today's typical 'trial and error' method toward a more powerful predictive approach to vaccine discovery and development," he said.

Through these integrated studies, Seattle BioMed researchers will deliver a set of candidate immune biomarkers associated with protection against malaria infection that can be used for monitoring vaccine efficacy. "This will facilitate future malaria vaccine trials with the ultimate goal of accelerating the development of a highl
'/>"/>

SOURCE Seattle Biomedical Research Institute
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Transgenomic, Inc. Presentations to Describe High-Sensitivity Detection of Cancer Biomarkers at the 2011 American Association for Cancer Research Meeting
2. Reportlinker Adds Biomarkers - Technologies, Markets and Companies
3. Vermillion Announces Notice of Allowance of Patent for Breast Cancer Biomarkers
4. Reportlinker Adds Biomarkers - Technologies, Markets And Companies
5. Biomarkers in Late Stage Clinical Trials: Applications, Opportunities and Activities of Leading Players
6. LifeGen Technologies Awarded NIH Grant to Identify Biomarkers of a Calorie Restricted Diet in Adipose Tissue
7. Reportlinker Adds Biomarkers: Discovery Techniques and Applications - A Global Market Overview
8. Reportlinker Adds Biomarkers - Technologies, Markets and Companies
9. MarketsandMarkets: Global Oncology Biomarkers Market Worth US$9.5 Billion by 2014
10. Frost & Sullivan Reveals Strategies on Turning Challenges into Opportunities in the European Biomarkers Market
11. Data on WaferGens SmartChip(TM) System to be Presented at 3rd Annual Rediscovering Biomarkers Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... Research and Markets ( http://www.researchandmarkets.com/research/jspg2c/global_biologics ... "Global Biologics and Biosimilars Industry Report 2015" ... The Global Biologics and Biosimilars Industry Report 2015 ... current state of the biologics and biosimilars industry. ... of the industry including definitions, classifications, applications and ...
(Date:3/4/2015)... , March 4, 2015  BioClinica®, ... and technology provider, today announced that clinical ... countries convened at its annual European User ... to discuss the use of its ... BioClinica,s eClinical technologies include: the Microsoft Office-Smart ...
(Date:3/4/2015)... Massachusetts , March 4, 2015 ... präsentiert innovative Entwicklungen für Diagnostik und Therapie, Strahlendosismanagement ...   Royal Philips (NYSE: ... Europäischen Röntgenkongress 2015 (ECR) bekannt, der ... stattfindet. An den Ständen Nr. 102 ...
(Date:3/3/2015)... Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced several new ... in North America , the Middle ... "Bidding activity in 2015 continues to be robust" said Derek ... for bidding in 2014, we are pleased to see the bidding ... organization,s renewed focus on select market segments where we can add ...
Breaking Biology Technology:Global Biologics and Biosimilars Industry Report 2015-2020 2BioClinica Teams With Pharma To Tackle Clinical Trial Challenges In Europe 2BioClinica Teams With Pharma To Tackle Clinical Trial Challenges In Europe 3Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 2Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 3Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 4Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 5Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 6
... SUNNYVALE, Calif., April 11 Accuray,Incorporated (Nasdaq: ... field of radiosurgery,today announced that the Hirslanden Clinic ... private hospitals, has purchased a CyberKnife System.,This marks ... greater,access to the benefits of extracranial radiosurgery., ...
... - AEterna Zentaris Inc.,(Nasdaq: AEZS TSX: AEZ;), a ... today announced that David J. Mazzo, Ph.D.,has resigned ... member of the,Board of Directors of AEterna Zentaris, ... the Board of AEterna Zentaris, has been,appointed as ...
... In the event of an outbreak or a bioterrorist ... virulence or drug resistance is essential to mounting an ... a pathogen genome is time-intensive and likely impractical during ... comparative genomics strategy to drastically reduce the time needed ...
Cached Biology Technology:First CyberKnife System Sold in Switzerland 2First CyberKnife System Sold in Switzerland 3First CyberKnife System Sold in Switzerland 4AEterna Zentaris Announces Changes to its Management Team 2Scientists develop strategy to rapidly describe outbreak strains with next-generation DNA sequencing 2
(Date:2/24/2015)... Feb. 24, 2015 This report analyzes the worldwide markets ... Segments: Face Biometrics, and Voice Biometrics. The report provides separate comprehensive ... Japan , Europe , Asia-Pacific ... Africa , and Latin America . Annual ... Also, a seven-year historic analysis is provided for these markets. Market ...
(Date:2/18/2015)... , Feb. 18, 2015  Cepheid (NASDAQ: ... at the following conferences, and invited investors to participate via ... Boston, MA Tuesday, March 3, 2015 at ... Conference, Orlando, FL Wednesday, March 4, ... Webcasts To access the live webcasts for these events, please ...
(Date:2/11/2015)... 2015 According to ... Market by Product (Cards and Readers, Biometrics, Controllers, Management ... Industrial, Healthcare, Education) and By Geography - Global Forecast and Analysis ... Access Control Market is expected to reach ... CAGR of 10.6% between 2014 and 2020. ...
Breaking Biology News(10 mins):World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16Cepheid to Webcast Upcoming Financial Presentations 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4
... of California, San Diego have built a small fleet ... air quality in real time on their smart phones. ... from chronic conditions, such as asthma, who need to ... air-quality monitoring system capable of delivering real-time data to ...
... The Hass Avocado Board (HAB) is supporting ... benefits of consuming fresh avocados to human health ... investigate the relationship between avocado consumption and risk ... in weight management and diabetes, and avocados, ability ...
... ANN ARBOR A comprehensive map three years in the ... Great Lakes, identifying how "environmental stressors" stretching from Minnesota to ... 20 percent of the world,s fresh water. In an ... Proceedings of the National Academy of Sciences , a group ...
Cached Biology News:Small, portable sensors allow users to monitor exposure to pollution on their smart phones 2Small, portable sensors allow users to monitor exposure to pollution on their smart phones 3Small, portable sensors allow users to monitor exposure to pollution on their smart phones 4Hass Avocado Board study published in Food & Function journal 2Environmental threat map highlights Great Lakes restoration challenges 2Environmental threat map highlights Great Lakes restoration challenges 3Environmental threat map highlights Great Lakes restoration challenges 4
...
Acrylamide, 500 g. Assay: > 99.9%, acrylic acid: < 0.001%. Conductivity (35%): < 2 umhos/cm.Risks: 45, 46, 48, 23, 24, 25 ; Safety Precautions: 53, 44. Category: Nucleotides & Enzymes & Biochemicals...
Direct ELISA Assay Diluent - EDTA, 10 L...
... into an automated, high-throughput operation with the ... is ideal for analyzing multiple PCR products, ... automated, robot-compatible, and ready to put into ... high-throughput screening assignments as easy as Plug ...
Biology Products: