Navigation Links
New 1-step process for designer bacteria
Date:5/28/2013

A simpler and faster way of producing designer bacteria used in biotechnology processes has been developed by University of Adelaide researchers.

The researchers have developed a new one-step bacterial genetic engineering process called 'clonetegration', published in the journal ACS Synthetic Biology.

Led by Dr Keith Shearwin, in the University's School of Molecular and Biomedical Sciences, the research facilitates faster development of designer bacteria used in therapeutic drug development, such as insulin, and other biotechnology products.

Designer bacteria are produced by integrating extra pieces of genetic material into the DNA of bacteria, in this case E. coli, so that the bacteria will make a desired product.

"E. coli strains are commonly used workhorses for biotechnology and metabolic engineering," Dr Shearwin says.

"For example, new genes or even the genetic material for whole metabolic pathways are inserted into the bacteria's chromosome so that they produce compounds or proteins not normally produced. Insulin is an example of a therapeutic product produced in this way."

"The existing process for integrating new genes is inefficient, taking several days. Our new process can be completed overnight."

As well as speeding up the process, 'clonetegration' enables multiple rounds of genetic engineering on the same bacteria, and simultaneous integration of multiple genes at different specific locations.

"This will become a valuable technique for facilitating genetic engineering with sequences that are difficult to clone as well as enable the rapid construction of synthetic biological systems," Dr Shearwin says.


'/>"/>

Contact: Dr. Keith Shearwin
keith.shearwin@adelaide.edu.au
61-883-135-361
University of Adelaide
Source:Eurekalert

Page: 1

Related biology technology :

1. ZyGEM and USAMRIID Sign CRADA for Development of Simplified Sample Processing Solutions for Biothreat Agents
2. Powerful AAC Device With Intel® i7 Processor Enables Natural Communication for Stroke, ALS and Autism Patients
3. Van Andel Research Institute Study Provides New Details of Fundamental Cellular Process
4. Improved Cord Blood Processing Research on BioLife Solutions CryoStor® Published in TRANSFUSION
5. KGI Selected to Administer PSM Affiliation Process
6. Cobalt Technologies Hits Key Commercial Milestone with Pretreatment Process Demonstration
7. Cepheid Receives Grant to Develop Sample Processing and Amplification Methods for Detection of Bloodstream Bacteria
8. Proteins shine a brighter light on cellular processes
9. How the alphabet of data processing is growing: Research team generates flying qubits
10. Honeycombs of magnets could lead to new type of computer processing
11. UK company to demonstrate their commercially effective graphene production process
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... In a list published by the ... state’s 76 fastest-growing private companies; a small percentage of the state's 615,000+ small businesses. ... the percent change in revenue from 2012 to 2015. , As this ...
(Date:5/3/2016)... , May 3, 2016 ... Assessing Developers and Producers of Those Competitor Biologics  ... to Companies, Activities and Prospects ,  Who ... companies? And what are their sales potentials? Discover, ... you see results, trends, opportunities and revenue forecasting. ...
(Date:5/2/2016)... ... May 02, 2016 , ... Meister Media Worldwide launches ... look and added functionality give the agricultural world a taste of Meister Media ... in agriculture – from precision farming via satellites and Unmanned Aerial Vehicles (UAVs) ...
(Date:4/29/2016)... ... April 29, 2016 , ... Amendia, ... spinal surgical procedures, today announced the completion of a significant transaction and partnership ... and future customers and partners. Kohlberg & Company, L.L.C. (“Kohlberg”), a leading ...
Breaking Biology Technology:
(Date:4/13/2016)... April 13, 2016  IMPOWER physicians supporting Medicaid patients ... a new clinical standard in telehealth thanks to a ... the higi platform, IMPOWER patients can routinely track key ... body mass index, and, when they opt in, share ... visit to a local retail location at no cost. ...
(Date:3/22/2016)... , March 22, 2016 ... report "Electronic Sensors Market for Consumer Industry by Type ... Others), Application (Communication & IT, Entertainment, Home ... Global Forecast to 2022", published by MarketsandMarkets, ... expected to reach USD 26.76 Billion by ...
(Date:3/15/2016)... 15, 2016 --> ... Transparency Market Research "Digital Door Lock Systems Market - Global ... 2023," the global digital door lock systems market in terms ... and is forecast to grow at a CAGR of 31.8% ... and medium enterprises (MSMEs) across the world and high industrial ...
Breaking Biology News(10 mins):