Navigation Links
Neuroscience method of optogenetics as good as electrical stimulation
Date:12/12/2013

ation method compared to no stimulation were small, but statistically significant. When the T was in the receptive field, one research subject became 10 percentage points more accurate (80 percent vs. 70 percent) when optically stimulated and eight points more accurate when electrically stimulated. The subject was five points less accurate (73 percent vs. 78 percent) with optical stimulation and six percentage points less accurate with electrical stimulation when the distracting character was in the receptive field.

The other subject showed similar differences. In all, the two primates made thousands of choices over scores of sessions between the T and the distracting character with either kind of stimulation or none. Compared head-to-head in a statistical analysis, electrical and optical stimulation showed essentially similar effects in biasing the decisions.

Optical advantages

Although the two methods performed at parity on the main measure of accuracy, the optogenetic method had a couple of advantages, Sheinberg said.

Electrical stimulation appeared to be less precise in the cells it reached, a possibility suggested by a reduction in electrically stimulated subjects' reaction time when the T appeared outside the receptive field. Optogenetic stimulation, Sheinberg said, did not produce such unintended effects.

Electrical stimulation also makes simultaneous electrical recording very difficult, Sheinberg said. That makes it hard to understand what neurons do when they are stimulated. Optogenetics, he said, allows for easier simultaneous electrical recording of neural activity.

Sheinberg said he is encouraged about using optogenetics to investigate even more sophisticated questions of cognition.

"Our goal is to be able to now expand this and use it again as a daily tool to probe circuits in more complicated paradigms," Sheinberg said.

He plans a new study in which his group will look at me
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3 4

Related biology technology :

1. Elsevier and the Neuroscience Information Framework Work Together to Improve Reporting of Research in Neuroscience Literature
2. CIRTEMO to Launch Multivariate Optical Element Platform for Neuroscience Applications
3. Pipette.com Announces Promotional T-Shirt and Other Specials for Neuroscience 2013
4. Elekta Opens Global Education Center for Oncology and Neuroscience Professionals
5. Saint Lukes Neuroscience Institute Announces 2013 Symposium
6. Blanchette Rockefeller Neurosciences Institute Partners with Neurotrope BioScience to Advance New Alzheimers Disease Discoveries
7. Biotrial, a Successful Leading CRO, Continues to Expand its Activities, Creating a Unique Neuroscience Pool of Talent and Capabilities: Biotrial Neuroscience
8. Intellect Neurosciences, Inc. to Present at Neurotech Investing and Partnering Conference
9. Trinity College Dublins Neuroscience and Bioengineering Programmes Receive Postgraduate Course of the Year Awards
10. Intellect Neurosciences Adds Two New Tau Programs to its Alzheimers Disease Development Pipeline
11. Intellect Neurosciences Enters Collaboration Agreement with Leading Alzheimers Research Group at University of California Irvine to Test First in Class Dual Target Vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Neuroscience method of optogenetics as good as electrical stimulation
(Date:7/3/2015)... Texas (PRWEB) , ... July 03, 2015 , ... ... firm, highly-regarded by Fortune 500 companies and professional service industries alike-- typically known ... to make clients laugh, honor a good cause and break from their day ...
(Date:7/3/2015)... Forskere kan ansøge ... http://www.openinnovationinscience.at om efteruddannelsesprogrammet "Lab for Open ... Wien .  ... og videnskabsmænd foretaget af Ludwig Boltzmann Gesellschaft ... sundhedsvidenskaben manglen på incitamenter til at undersøge ...
(Date:7/2/2015)... , ... July 02, 2015 , ... Sleepless nights will ... individual’s quality of sleep, launched its Indiegogo campaign on June 23. Sound sleepers and ... command technology makes it effortless to use, while the integration of the Bluetooth speaker, ...
(Date:7/1/2015)... ... 2015 , ... The next-generation sequencing (NGS) clinical market is poised for huge ... industry. BCC Research reveals in its new report that the market drivers of this ... growing need for better diagnostics as part of a molecular diagnostics trend. , The ...
Breaking Biology Technology:The Alexander Group Declares Their Independence with a Bit of Levity 2Lancering af verdens første åbne innovationsprogram til uddannelse af forskere 2Lancering af verdens første åbne innovationsprogram til uddannelse af forskere 3Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3
... COVINA, Calif., May 16 StemCyte Inc. today announced,that ... company,overview with a focus on the StemCyte,s Indian joint ... Bhat will present during the session on "Stem ... the Art" on Saturday, May 17. His,presentation will include ...
... George Abercrombie, president,and chief executive officer, Hoffmann-La Roche ... today at a Rotary Club of Fort Worth ... businesses with challenges,unlike those anticipated with traditional emergency ... familiar with preparing for potential,disasters such as floods ...
... NEW YORK and HAIKOU, China, May 16 ... (OTC Bulletin Board: CPHI),which develops, manufactures, and ... announced today that it donated 2,million RMB ... anti- virus and anti-cold medicines to help ...
Cached Biology Technology:StemCyte Chief Scientific Officer to Present Company Overview with Focus on Indian Joint Venture at TiEcon 2008 2CEO Addresses Fort Worth Business Leaders About Developing Pandemic and Business Continuity Plans 2CEO Addresses Fort Worth Business Leaders About Developing Pandemic and Business Continuity Plans 3China Pharma Holdings, Inc. Donates Medicine for Sichuan Earthquake Relief 2
(Date:6/11/2015)... , June 11, 2015 Daon, ... announced today that its IdentityX Mobile Authentication Platform ... IDentity Online) Alliance is an industry consortium launched ... standards for simpler, stronger authentication.  In order to ... pass a rigorous series of tests that measure ...
(Date:6/9/2015)... , June 9, 2015   MedNet Solutions ... the entire spectrum of clinical research, will be providing ... technology platform at the 2015 Drug Information Association (DIA) ... on June 15-17.  These presentations will include previews of ... out in the upcoming iMedNet 2015 Feature ...
(Date:6/8/2015)...  Trovagene, Inc. (NASDAQ: TROV ), a developer of ... Precision Cancer Monitoring SM platform will be presented at ... San Diego, CA on June 11-12 ... Clinical Genomics and Cancer Therapy in Salt ... "We continue to advance our clinical programs and present ...
Breaking Biology News(10 mins):Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2MedNet To Provide Sneak Peeks Of Its iMedNet "2015 Feature 1 Release" At The DIA Annual Meeting 2MedNet To Provide Sneak Peeks Of Its iMedNet "2015 Feature 1 Release" At The DIA Annual Meeting 3Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 2Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 3Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 4
... The Endocrine Society advocates that all methods for measuring ... be made traceable to a common standard. ... sexual development, these hormones, particularly estradiol, have a significant ... bones, muscle, kidney, liver, digestive system, brain, lung and ...
... in oily fish may have diverse health-promoting effects, potentially ... But how the health effects of one such fatty ... in part because its molecular signaling pathways are only ... of Physiology, at the Perelman School of Medicine, University ...
... New research from Rice University, Baylor College of Medicine (BCM) ... stresses of flow in the small blood vessels of the ... shape and form dangerous blood clots. The scientists were surprised ... clot-initiating shape for up to five hours before returning to ...
Cached Biology News:Better estrogen-testing methods needed to improve patient care 2Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model 2Stressed proteins can cause blood clots for hours 2Stressed proteins can cause blood clots for hours 3