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NeurogesX Provides U.S. Regulatory Update for Qutenza(TM)
Date:6/10/2009

approval for Qutenza; any regulatory approvals which are received may be limited to certain indications; NeurogesX' product candidates may have unexpected adverse side effects or inadequate therapeutic efficacy; and other difficulties or delays in, clinical development of, and obtaining regulatory approval for NeurogesX' product candidates. For further information regarding these and other risks related to NeurogesX' business, investors should consult NeurogesX' filings with the Securities and Exchange Commission.

    NeurogesX, Inc.             The Ruth Group
    Stephen Ghiglieri           Sara Pellegrino (investors)
    Chief Financial Officer     (646) 536-7002
    (650) 358-3310              spellegrino@theruthgroup.com

                                Jason Rando (media)/Janine McCargo
                                (646) 536-7025/7033
                                jrando@theruthgroup.com
                                jmccargo@theruthgroup.com



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