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NeurogesX Appoints New Board Director and Audit Committee Chairman
Date:8/25/2009

of the Safe Harbor for forward-looking statements contained in the Act. Examples of such statements include, but are not limited to the timing and outcome of regulatory decisions and label approval being sought or that may be obtained with respect to the NDA for Qutenza with the FDA, including the PDUFA date for the NDA; plans and timing for commercialization of Qutenza and development activities for NGX-1998 and other product candidates, including regulatory submissions and any outcomes of such submissions. Such statements are based on management's current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to; positive results in clinical trials may not be sufficient to obtain FDA approval; the FDA may request additional clinical trials or other information prior to granting approval for Qutenza; any regulatory approvals which are received may be limited to certain indications; NeurogesX' product candidates may have unexpected adverse side effects or inadequate therapeutic efficacy or tolerability; physician or patient reluctance to use Qutenza or NGX-1998, if approved; and other difficulties or delays in, clinical development of, and obtaining regulatory approval for NeurogesX' product candidates. For further information regarding these and other risks related to NeurogesX' business, investors should consult NeurogesX' filings with the Securities and Exchange Commission.

    NeurogesX, Inc.               The Ruth Group
    Stephen Ghiglieri             Sara Pellegrino (investors)
    Chief Financial Officer       (646) 536-7002
    (650) 358-3310                spellegrino@theruthgroup.com

                                  Jason Rando (media)
                                  (646) 536-7025
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1. NeurogesX Reports Second Quarter 2009 Results
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3. NeurogesX to Hold Conference Call to Discuss Second Quarter 2009 Financial Results
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5. NeurogesX Provides U.S. Regulatory Update for Qutenza(TM)
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7. NeurogesX Receives European Commission Approval for Qutenza(TM)
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10. NeurogesX Presents Two Posters at 61st Annual American Academy of Neurology Annual Meeting
11. NeurogesX to Hold Conference Call to Discuss Fourth Quarter and Year-End 2008 Financial Results and European Regulatory Update
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