Navigation Links
Neurogenetic studies show proprietary compound reduces brain plaques linked to Alzheimer's
Date:9/9/2010

SAN DIEGO -- In the Sept 9, 2010 issue of Neuron, Neurogenetic Pharmaceuticals, Inc. (NGP) reports proof of concept studies that show its proprietary compound, NGP 555, is effective in preventing the amyloid pathology of Alzheimer's disease (AD) in a transgenic mouse model. The study further demonstrates that following chronic treatment with the gamma secretase modulator (GSM) compound from NGP, the mice were devoid of gastrointestinal side effects, an adverse finding commonly associated with gamma secretase inhibitors (GSIs).

A major pathological hallmark of Alzheimer's disease is an abundance of neuritic plaques in key areas of the brain involved in memory and cognition. Decades of studies have confirmed that Aβ42 forms the "seed" of these amyloid plaques, which gradually accumulate in the brain and induce neuronal cell death in the underlying brain tissue. This "toxic" molecule is generated by a stepwise process involving a pivotal enzyme, gamma secretase. Modification of gamma secretase activity to decrease production of Aβ42, thereby reducing the deposits of Aβ42 -seeded plaques, would be beneficial for the prevention of Alzheimer's disease-related pathology.

"We are pleased to make public these data on our gamma secretase modulator, NGP 555," said Dr. William T. Comer, President and CEO of Neurogenetic Pharmaceuticals. "Deposition of amyloid plaques can precede dementia by many years, and the progression of plaques to dementia reflects neuronal loss which is irreversible. We believe that halting this gradual progression of AD from pathology to dementia represents a major unmet need, especially given the growth of an aging population and the enormous cost to society for care and hospitalization. Recent advances in the use of A biomarkers in the cerebrospinal fluid and brain scans should permit early diagnosis of AD pathology and allow us to show that NGP 555 prevents the amyloid pathology."

T
'/>"/>

Contact: Tom Gable
tom@gablepr.com
877-251-3888
Gable PR
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Health Robotics Releases Results of First 20 i.v.STATIONs Return On Investment (ROI) Studies in the USA and Canada
2. New hydrolysis model promising tool in cellulosic biofuel studies
3. Stretching single molecules allows precision studies of interacting electrons
4. Genomic Health Presents Six New Studies Including Four Oral Presentations in Breast, Colon and Renal Cancers at American Society of Clinical Oncology (ASCO) Annual Meeting
5. Agendia Presents Broad Array of Predictive and Prognostic Studies on Breast and Colorectal Cancers at ASCO 2010 Annual Meeting
6. Advanced Phase I and Phase II Studies of Targeted Gene Delivery Confirm That Rexin-G Impacts Survival in Chemotherapy-resistant Bone and Soft Tissue Sarcoma (ASCO 2010)
7. Studies Demonstrate Early Stage Detection and Economic Benefits of a Blood-Based Test for Lung Cancer
8. Tumor-Targeted Rexin-G Prolongs Survival in Gemcitabine-Resistant Metastatic Pancreas Cancer in Advanced Phase I and II Studies (ASCO 2010)
9. Lilly Oncology to Unveil More Than 50 Studies at ASCO 2010
10. Encorium Group, Inc. Announces New Business Contract Wins of $6.8 Million, Including Two Pivotal Phase III Studies for a Major Asian Technology Company
11. Epeius Biotechnologies Reports Major Clinical Advances: Noteworthy Clinical Case Studies in Cancer Gene Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/19/2014)... report "Chocolate, Cocoa Beans, Lecithin, Sugar and Vanilla Market ... (2011 - 2016)," analyzes the chocolate market by ... market drivers, restraints, and opportunities for the chocolate market ... chocolate market is expected to grow from $83.2 billion ... CAGR of 2.7% from 2011 to 2016. , Get ...
(Date:10/18/2014)... The “Human Insulin Market- by Product Type, [Human ... Insulin (Rapid Acting, Long Acting, Premixed)], by Brand ... Forecast to 2018” provides a detailed overview of ... trends, and strategies impacting the global human insulin ... the revenue and share analysis. , The global ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 The Asia-Pacific ... concerned market in Asia-Pacific with analysis and forecast of ... and is expected to reach $51,362.6 million by 2018, ... , Browse through the TOC of the Asia-Pacific hardware ... in-depth analysis provided. This also provides a glimpse of ...
(Date:10/18/2014)... 18, 2014 According to a new ... Well Type - Global Trends & Forecasts up till ... billion in 2011. This value is expected to increase ... 2017, with 10% CAGR during the same period. North ... production market in terms of hydraulic horse power supplied ...
Breaking Biology Technology:Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 2Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 4
... 9 ThermoGenesis,Corp. (Nasdaq: KOOL ), a ... and store adult stem cells, today said that ... than doubled over the same period,a year ago. ... has signed,a distribution agreement with Celling Technologies for ...
... Minn., Sept. 9 For the second consecutive,year, ... clinical study management systems, has been recognized by,Inc. ... growing private,organizations. With consistently strong growth over the ... company in the Twin Cities,metro area, and fifth ...
... LONDON, September 8, 2008 / b3c newswire ... seem to have hit the European pharmaceutical industry yet.  ... in past years, eyeforpharma’s upcoming Marketing Summit Europe, October ... biggest event of its kind ever. , ,Companies obviously ...
Cached Biology Technology:ThermoGenesis Reports Record Quarterly Revenues of $7.2 Million; Full Year Revenues Increase 31 Percent 2ThermoGenesis Reports Record Quarterly Revenues of $7.2 Million; Full Year Revenues Increase 31 Percent 3ThermoGenesis Reports Record Quarterly Revenues of $7.2 Million; Full Year Revenues Increase 31 Percent 4ThermoGenesis Reports Record Quarterly Revenues of $7.2 Million; Full Year Revenues Increase 31 Percent 5ThermoGenesis Reports Record Quarterly Revenues of $7.2 Million; Full Year Revenues Increase 31 Percent 6ThermoGenesis Reports Record Quarterly Revenues of $7.2 Million; Full Year Revenues Increase 31 Percent 7ThermoGenesis Reports Record Quarterly Revenues of $7.2 Million; Full Year Revenues Increase 31 Percent 8ThermoGenesis Reports Record Quarterly Revenues of $7.2 Million; Full Year Revenues Increase 31 Percent 9MedNet Solutions Again Recognized as one of the Fastest Growing US Companies 2Eyeforpharma's Marketing Summit is shaping up to be the biggest event of its kind ever 2
(Date:10/16/2014)... Syncytial Virus causes severe respiratory tract infections and ... year. Scientists at VIB and Ghent University have ... counteract this common virus infection. , Xavier ... that paves the way for the development of ... virus that causes suffering in numerous small children ...
(Date:10/15/2014)... 15, 2014 Sandata Technologies, LLC, an ... community-based care, today announced it released a case ... Electronic Visit Verification™ Solution (EVV™)  for Quality Care ... health company founded in 1996 and has five ... The study details the challenges facing ...
(Date:10/15/2014)... German Gauß-Allianz has admitted Johannes Gutenberg University Mainz ... Rhineland-Palatinate science hub continues to maintain a significant ... , "The acceptance of Johannes Gutenberg University ... is a milestone in the national and international ... The state of Rhineland-Palatinate can be proud that ...
Breaking Biology News(10 mins):New perspectives for development of an RSV vaccine 2Sandata Announces Case Study with Quality Care Services, Inc. 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... 6, 2012 Efforts to begin human clinical trials ... pigmentosa received a $37.3 million boost from the California ... of funding on Sept. 5. UC Irvine ... CIRM Disease Team Therapy Development Awards, which are designed ...
... 2012 -- After last year,s accidental discovery of "zombie"-like bees ... an elaborate experiment to learn more about the plight of ... with tiny radio trackers, and monitoring the bees, movements in ... the Hensill Hall biology building on campus. At the same ...
... Integrative Graduate Education and Research Traineeship (IGERT) program ... research and training programs for Ph.D. students at ... investigators is Thomas Cech, a University of Colorado, ... Prize in chemistry. In addition to the 123 ...
Cached Biology News:State stem cell research funding agency awards $37.3 million to aid UC Irvine efforts 2State stem cell research funding agency awards $37.3 million to aid UC Irvine efforts 3SF State biologists tag 'zombees' to track their flight 2SF State biologists tag 'zombees' to track their flight 3NSF interdisciplinary program takes on critical national research priorities 2NSF interdisciplinary program takes on critical national research priorities 3NSF interdisciplinary program takes on critical national research priorities 4NSF interdisciplinary program takes on critical national research priorities 5NSF interdisciplinary program takes on critical national research priorities 6
... Zyagen tissue microarrays are derived from Paraffin ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... on coated slides. Sections are large (3-5 ...
... from frozen embedded tissue blocks, which are ... ensure the highest quality. Tissues of each ... sectioned at a thickness of 7microns and ... (3-5mm in diameter) in comparison to core ...
... Precision-designed for Optimal Microdissection , ... enable the precise and rapid extraction of ... and cytology samples with Laser Capture Microdissection., ... for Downstream Molecular Analysis , All CapSure ...
... for Optimal Microdissection , CapSure HS and ... and rapid extraction of populations of pure ... with Laser Capture Microdissection., Ensure the ... Analysis , All CapSure LCM Caps have ...
Biology Products: