Navigation Links
Neurogenetic studies show proprietary compound reduces brain plaques linked to Alzheimer's
Date:9/9/2010

SAN DIEGO -- In the Sept 9, 2010 issue of Neuron, Neurogenetic Pharmaceuticals, Inc. (NGP) reports proof of concept studies that show its proprietary compound, NGP 555, is effective in preventing the amyloid pathology of Alzheimer's disease (AD) in a transgenic mouse model. The study further demonstrates that following chronic treatment with the gamma secretase modulator (GSM) compound from NGP, the mice were devoid of gastrointestinal side effects, an adverse finding commonly associated with gamma secretase inhibitors (GSIs).

A major pathological hallmark of Alzheimer's disease is an abundance of neuritic plaques in key areas of the brain involved in memory and cognition. Decades of studies have confirmed that Aβ42 forms the "seed" of these amyloid plaques, which gradually accumulate in the brain and induce neuronal cell death in the underlying brain tissue. This "toxic" molecule is generated by a stepwise process involving a pivotal enzyme, gamma secretase. Modification of gamma secretase activity to decrease production of Aβ42, thereby reducing the deposits of Aβ42 -seeded plaques, would be beneficial for the prevention of Alzheimer's disease-related pathology.

"We are pleased to make public these data on our gamma secretase modulator, NGP 555," said Dr. William T. Comer, President and CEO of Neurogenetic Pharmaceuticals. "Deposition of amyloid plaques can precede dementia by many years, and the progression of plaques to dementia reflects neuronal loss which is irreversible. We believe that halting this gradual progression of AD from pathology to dementia represents a major unmet need, especially given the growth of an aging population and the enormous cost to society for care and hospitalization. Recent advances in the use of A biomarkers in the cerebrospinal fluid and brain scans should permit early diagnosis of AD pathology and allow us to show that NGP 555 prevents the amyloid pathology."

The work published in Neuron is the first to describe these mechanistically and biochemically distinct GSM compounds and how they provide a more selective mechanism than GSIs. The key advantages of these small molecules include reduction of the "toxic" form of beta amyloid (Aβ42), direct binding to components of the gamma secretase complex, and excellent brain exposure. The paper demonstrated that Neurogenetic Pharmaceuticals' approach of gamma secretase modulation allows for selective reduction of Aβ42 and amyloid pathology. Oral administration of NGP 555 (identified as compound 4 in Neuron) in transgenic AD mice resulted in a dose-related lowering of both plasma and brain Aβ42. Chronic daily administration for 7 months led to significant reduction in both diffuse and neuritic plaques, without the GI-related side effects found with GSI compounds, according to the paper in Neuron. The work, conducted by researchers at TorreyPines Therapeutics (TPTX) in collaboration with academic institutions, concludes that these types of GSM compounds warrant further investigation as a potentially safe and effective approach for prevention of AD.

"This study links A biomarker and pathology findings with a mechanistic understanding of how our compounds selectively target a key enzyme involved in the pathology of Alzheimer's disease," said Maria Z. Kounnas, Ph.D., lead author on the study and vice president of Alzheimer's Research at NGP. "Combining early disease identification with a treatment capable of preventing AD-related pathology, such as NGP 555, would represent an important advance in our ability to prevent AD or hinder its progression to dementia. Clearly, the earlier AD is detected and treated, the better the likelihood of a good outcome."


'/>"/>

Contact: Tom Gable
tom@gablepr.com
877-251-3888
Gable PR
Source:Eurekalert

Related biology technology :

1. Health Robotics Releases Results of First 20 i.v.STATIONs Return On Investment (ROI) Studies in the USA and Canada
2. New hydrolysis model promising tool in cellulosic biofuel studies
3. Stretching single molecules allows precision studies of interacting electrons
4. Genomic Health Presents Six New Studies Including Four Oral Presentations in Breast, Colon and Renal Cancers at American Society of Clinical Oncology (ASCO) Annual Meeting
5. Agendia Presents Broad Array of Predictive and Prognostic Studies on Breast and Colorectal Cancers at ASCO 2010 Annual Meeting
6. Advanced Phase I and Phase II Studies of Targeted Gene Delivery Confirm That Rexin-G Impacts Survival in Chemotherapy-resistant Bone and Soft Tissue Sarcoma (ASCO 2010)
7. Studies Demonstrate Early Stage Detection and Economic Benefits of a Blood-Based Test for Lung Cancer
8. Tumor-Targeted Rexin-G Prolongs Survival in Gemcitabine-Resistant Metastatic Pancreas Cancer in Advanced Phase I and II Studies (ASCO 2010)
9. Lilly Oncology to Unveil More Than 50 Studies at ASCO 2010
10. Encorium Group, Inc. Announces New Business Contract Wins of $6.8 Million, Including Two Pivotal Phase III Studies for a Major Asian Technology Company
11. Epeius Biotechnologies Reports Major Clinical Advances: Noteworthy Clinical Case Studies in Cancer Gene Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/9/2017)... ... 2017 , ... The award-winning American Farmer television series will feature 3 Bar ... Tuesdays at 8:30aET on RFD-TV. , With global population estimates nearing ten billion ... continue to feed a growing nation. At the same time, many of our valuable ...
(Date:10/9/2017)... , ... October 09, 2017 ... ... on October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® ... gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface ...
(Date:10/7/2017)... 2017  The 2017 Nobel Prize in Chemistry ... Dubochet, Joachim Frank and Richard ... microscopy (cryo-EM) have helped to broaden the ... community. The winners worked with systems manufactured by ... highly resolved, three-dimensional images of protein structures that ...
(Date:10/5/2017)... ... ... LabRoots , the leading provider of educational and interactive virtual events ... cancer research with a month-long promotion supporting the advancement of breast cancer research with ... promo code PinkRibbon to get 10 percent off their purchase of every the “Cancer ...
Breaking Biology Technology:
(Date:3/30/2017)... 2017  On April 6-7, 2017, Sequencing.com will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
(Date:3/29/2017)... the health IT company that operates the largest health ... today announced a Series B investment from BlueCross BlueShield ... investment and acquisition accelerates higi,s strategy to create the ... activities through the collection and workflow integration of ambient ... secures data today on behalf of over 36 million ...
(Date:3/24/2017)... -- The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative high ... ... Maldives Immigration Controller ... (small picture on the right) have received the IAIR award for the ...
Breaking Biology News(10 mins):