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Neurocrine Biosciences Reports Fourth Quarter and Year End 2010 Results
Date:2/10/2011

ted to be conducted in both healthy volunteers and patients with stable congestive heart failure to determine the impact of urocortin 2 infusions on biomarkers of cardiovascular function and dysfunction.

The Company has completed several Phase I studies and two Phase II studies of urocortin 2 in patients with stable congestive heart failure. These Phase II studies showed urocortin 2 to be well tolerated with positive hemodynamic effects as evidenced by increases in cardiac output and efficiency.

VMAT2 UpdateThe Company's VMAT2 compound, NBI-98854, successfully completed two Phase I safety studies in healthy male volunteers. In late 2010, the Company initiated a Phase IIa dose exploration study of NBI-98854 in patients with Tardive Dyskinesia. This Phase IIa study consists of assessing approximately ten patients, using once-daily doses over a twelve day treatment period, escalating the dose after every fourth day. The assessment tool for this study is the Abnormal Involuntary Movement Scale (AIMS) and data is expected in April of this year.

Pending successful completion of this initial study in patients, the Company anticipates opening an Investigational New Drug (IND) application in the United States, and commencing a larger appropriately powered Phase IIb study during the second half of 2011.

Conference Call and Webcast Today at 5:00 PM Eastern TimeNeurocrine will hold a live conference call and webcast today at 5:00 p.m. Eastern Time (2:00 p.m. Pacific Time). Participants can access the live conference call by dialing 1-800-862-9098 (US) or 785-424-1051 (International) using the conference ID: 7NBIX. The call can also be accessed via the webcast through the Company's website at http://www.neurocrine.com.

If you are unable to attend the webcast and would like further information on this announcement please contact the Investor Relations Department at Neurocrine Biosciences at (858) 6
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SOURCE Neurocrine Biosciences, Inc.
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