CAMBRIDGE, Mass., Feb. 16, 2012 /PRNewswire/ -- NeuroPhage Pharmaceuticals, Inc. announced today that it has been awarded funding by The Michael J. Fox Foundation (MJFF) to conduct pre-clinical research targeting alpha-synuclein, a protein whose clumping is the pathological hallmark of Parkinson's disease (PD). This is NeuroPhage's first grant from MJFF.
"It is a privilege to collaborate with MJFF toward the development of our novel therapeutic approach. This grant will provide NeuroPhage with access to world class experts in PD and we look forward to a productive relationship with the Foundation," said Kimberley S. Gannon, PhD, Senior Vice President of Preclinical R&D at NeuroPhage.
NeuroPhage will test the effect of NPT001 (a novel therapeutic in development for Alzheimer's disease) on alpha-synuclein levels in a pre-clinical model of PD. In preliminary preclinical studies, NPT001 had been shown to reduce brain levels of alpha-synuclein.
"Alpha-synuclein is a high-priority target for our Foundation, as there is evidence that it may play a role in both genetic and idiopathic cases of PD," said Kuldip Dave, PhD, associate director of research programs at MJFF. "NeuroPhage's unique approach has the potential to reduce levels of alpha-synuclein in the brain, which could, in turn, lead to novel therapies to treat PD."
NeuroPhage's technology platform permits the development of therapeutics that target multiple misfolded proteins such as amyloid beta and tau (involved in Alzheimer's disease), as well as alpha-synuclein (involved in PD).
About Parkinson's Disease
Parkinson's disease is a chronic, progressive disorder of the central nervous system and results from the loss of cells in an area of the brain called the substantia nigra. These cells produce dopamine, a chemical messenger responsible for transmitting signals within the brain. Loss of dopamine causes
|SOURCE NeuroPhage Pharmaceuticals, Inc.|
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