CAMBRIDGE, Mass., Dec. 19, 2013 /PRNewswire/ -- NeuroPhage Pharmaceuticals, Inc. today announced that it has been awarded an $822,000 grant by The Michael J. Fox Foundation for Parkinson's Research (MJFF) for its second-generation drug candidate, NPT088, based on NeuroPhage's GAIM (general amyloid interaction motif) platform, which simultaneously targets multiple misfolded proteins central to many neurodegenerative diseases. In particular, the MJFF grant will be applied to research the effect of NPT088 on alpha-synuclein deposits in the brain, a pathological hallmark of Parkinson's disease (PD). This is NeuroPhage's second grant from MJFF applied to the GAIM platform.
"NeuroPhage is honored to receive its second grant from the MJFF, which supports our GAIM platform as a unique approach to the treatment of PD and other neurodegenerative diseases characterized by deposits of misfolded proteins. This award will allow us to make continued progress on our program in PD with our second-generation candidate, NPT088, continuing to build on our strong preclinical data," said Kimberley S. Gannon, PhD, Senior Vice President of Preclinical R&D at NeuroPhage.
The proceeds of the new MJFF grant will be used to test the effect of NPT088 on alpha-synuclein accumulation in the brain in a preclinical model of PD. The preclinical study will be conducted in collaboration with Dr. Eliezer Masliah at the University of California, San Diego. NeuroPhage previously demonstrated that a single treatment of NPT001, a first-generation GAIM molecule, produced significant reductions in neuropathology along with improved motor performance in preclinical PD models.
"We are pleased with the progress that NeuroPhage has made since our original collaboration began in June 2011 under a Therapeutics Development Initiative Award," said Kuldip Dave, PhD, Senior Associate Director of Research Programs at MJFF.
|SOURCE NeuroPhage Pharmaceuticals, Inc.|
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