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Neuralstem Receives Final Notice of Allowance for New Stem Cell Immortalization Technology Patent
Date:1/26/2009

ROCKVILLE, Md., Jan. 26 /PRNewswire-FirstCall/ -- Neuralstem, Inc. (NYSE Alternext US: CUR) today announced that it has received Official Notice of Allowance for its patent application, number 10/047,352, for Stable Neural Stem Cell Lines from the US Patent and Trade Office (USPTO). This patent covers the technology to immortalize any human neural stem cell, rendering its growth robust and long-lasting.

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"We are pleased to have received the Notice of Allowance on this important technology," said President & CEO Richard Garr. "The technology behind this patent allows us to grow practically unlimited quantities of neural stem cells from all regions of the brain without regard to the natural mitotic (growth) limits of cells from a particular region. Equally important, this technology is a next-generation immortalization process that avoids the harmful effects of traditional immortalization methods, which have invariably resulted in uncontrolled growth. Our technology provides the necessary assurance that the cell lines are fully controlled and remain consistent trial-over-trial and year-after-year. This consistency is ultimately key to the commercialization of any cell products and greatly enhances our ability to deliver cell therapies for very prevalent diseases, such as stroke and traumatic brain injury. It will also enable, for the first time, systematic drug screening against many different kinds of normal human brain cells for new Central Nervous System (CNS) drugs, and stem cell-mediated protein delivery for neurologic diseases."

About the Technology

The newly patented method uses cMyc-ER, a recombinant fusion of two proteins normally present in cells, c-Myc, a human cell-cycle regulating protein, and estrogen receptor (ER), a human protein that is activate
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