Navigation Links
Nereus Pharmaceuticals Initiates Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer Following Encouraging Phase 1 Data
Date:3/20/2008

SAN DIEGO, March 20 /PRNewswire/ -- Nereus Pharmaceuticals, Inc., a pioneer in drug discovery from marine microbial sources, today announced that enrollment has begun in a Phase 1b study evaluating the vascular disrupting agent (VDA) NPI-2358 in combination with standard chemotherapy in patients with non-small cell lung cancer (NSCLC). This study follows on positive outcomes in a Phase 1 single-agent clinical trial assessing the safety, pharmacokinetics, pharmacodynamics (PK/PD) and efficacy of NPI-2358 in various tumor types.

The open-label Phase 1b study will assess escalating doses of NPI-2358 in combination with docetaxel in patients with NSCLC who previously failed at least one chemotherapy regimen. The existing preclinical and clinical data suggests that VDAs may be complementary or synergistic with chemotherapeutics and anti-angiogenesis agents due to the different targets and mechanisms of action. NPI-2358 has a dual effect on tumors: It selectively attacks existing tumor blood vessels leading to hemorrhagic tumor necrosis without affecting normal vasculature, and it has a direct apoptotic effect on tumors cells. NPI-2358 in combination with chemotherapeutic agents in human xenograft models of NSCLC and other cancers was markedly more effective than either treatment alone.

"We are excited to have a leading role in the clinical development of Nereus' NPI-2358 for the treatment of non-small cell lung cancer. At The Sir Charles Gairdner Hospital, we felt this combination study with NPI-2358 was a high priority given the favorable preclinical and clinical data we have seen," said Michael Millward, M.D., Cancer Council Professor of Clinical Cancer Research at The University of Western Australia based at Sir Charles Gairdner Hospital, Perth.

"Our clinical program for NPI-2358 holds promise in non-small cell lung cancer, a large market indication where novel compounds could make a significant impact on patients. We're pleased to advance
'/>"/>

SOURCE Nereus Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Vion Pharmaceuticals Pays Interest on 7.75% Convertible Senior Notes
2. China Biopharmaceuticals Holdings Announces Second Quarter 2007 Financial Results
3. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
4. XTL Biopharmaceuticals Announces Financial Results for the Six Months Ended June 30, 2007
5. Cadence Pharmaceuticals Reports Second Quarter 2007 Financial Results
6. Nabi Biopharmaceuticals to Present at Upcoming Industry Conferences
7. Anadys Pharmaceuticals Appoints Steve Worland, Ph.D. as President and Chief Executive Officer
8. Poniard Pharmaceuticals Announces Participation in Upcoming Conferences
9. NovaQuest Advances Virtual Development Model With Strategic Investment in TOPIGEN Pharmaceuticals
10. Drug Royalty Corporation (DRC) Announces Acquisition Regarding PEG-INTRON(R) From Enzon Pharmaceuticals, Inc. (ENZN)
11. Sunesis Pharmaceuticals Announces Reorganization to Focus Resources and Build Value in Clinical-Stage Programs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... Md. , April 1, 2015 ... of pathogen-specific therapies for serious infections and diseases, ... announced that clinical data supporting the development of ... certain beta-lactam intravenous (IV) antibiotics within the gastrointestinal ... the gut microbiome for the prevention of ...
(Date:4/1/2015)... Md. , April 1, 2015  Spherix ... company committed to the fostering and monetization of ... LLC, a privately held full service global investment ... recently issued an industry note featuring Spherix. ... , CFA, a Senior Analyst at Chardan, was ...
(Date:4/1/2015)... CA (PRWEB) April 01, 2015 The concept ... loss, a multi-billion dollar industry. Founder of Fasciology, Ashley Black, ... an area of fat, instead of having to wait for ... Black claims that “ prior to fat cooling procedures, ... sculpting or contouring, was liposuction, which is a highly invasive ...
(Date:4/1/2015)... April 01, 2015 National recruitment firm ... placement of Brad Allen as Head of Sales at ... health system market. , Allen brings over 20 ... sales at a number of companies including Dell Services ... and experience were a perfect fit for accomplishing the ...
Breaking Biology Technology:Synthetic Biologics' SYN-004 Clinical Data for Protection of Microbiome Selected for Poster Presentation at American Society of Microbiology 2015 2Synthetic Biologics' SYN-004 Clinical Data for Protection of Microbiome Selected for Poster Presentation at American Society of Microbiology 2015 3Synthetic Biologics' SYN-004 Clinical Data for Protection of Microbiome Selected for Poster Presentation at American Society of Microbiology 2015 4Chardan Capital Issues Industry Note Covering Spherix 2Chardan Capital Issues Industry Note Covering Spherix 3Hybrid Health Guru, Ashley Black, announces that her invention The FasciaBlaster™ rivals the “fat cooling” procedures that reduce exercise and diet resistant fat pockets. 2Hybrid Health Guru, Ashley Black, announces that her invention The FasciaBlaster™ rivals the “fat cooling” procedures that reduce exercise and diet resistant fat pockets. 3Slone Partners Fills Head of Sales at Optimal Medicine 2
... ... in its Intellectual Property Group and will be practicing primarily out of its Portland office. ... ... -- Today Preti Flaherty announced that Wayne Keown has joined the ...
... MediSens Wireless, a startup company in UCLA,s on-campus ... obtained approval under federal Food and Drug Administration ... wireless body-monitoring system, which assesses muscle and neuromotor ... The Clinical Movement Assessment System (CMAS) is ...
... WILMINGTON, Del. , and FLORHAM PARK, N.J. , Jan. ... Science announced they have reached an agreement on a patent infringement dispute. ... each other in U.S. Federal Court in the District of Delaware ... including traits that provide tolerance to ALS herbicides. , DuPont and BASF ...
Cached Biology Technology:Attorney Wayne Keown Joins Preti Flaherty's Portland, ME Office 2Startup at UCLA tech incubator to begin clinical trials for wireless body-monitoring system 2DuPont and BASF Announce Settlement 2DuPont and BASF Announce Settlement 3
(Date:3/24/2015)... March 24, 2015   NexID Biometrics LLC, ... security-authentication needs, today announced the beginning of shipments of ... The company, based in Potsdam, ... three-day Connect:ID Expo, which began here today at the ... version 2.0 of its SDK boosts the accuracy rate ...
(Date:3/23/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... commerce market, announces its biometric payment technology, the Wocket® smart ... starting March 30 th . The ... New York markets. Gino ... our new ad campaign following the recent initial shipment of ...
(Date:3/19/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... commerce market, announces its biometric payment technology, the Wocket® smart ... week on Washington DC,s Fox 5 ... "The Next Great Thing", host Laura Evans calls ... ,a really big breakthrough in mobile payment.,  ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3
... team at the Moores Cancer Center at University of California, ... (CLL) who were treated with a gene therapy protocol began ... study will be published on line the week of February ... National Academy of Science. Researchers led by Thomas J. ...
... health of coastal waters degraded by nutrient pollution, ... for prioritizing stream restoration efforts aimed at reducing ... published in the online version of the journal ... practitioners to make better informed decisions regarding the ...
... EVANSTON, Ill. --- In the science world, in the ... continues over how carbon in the atmosphere is affecting ... the Earth is an enormous challenge, but one Northwestern ... important segment -- rivers. Aaron Packman, associate professor ...
Cached Biology News:Gene therapy protocol at UCSD activates immune system in patients with leukemia 2New research offers prioritization plan for reducing nutrient pollution in feeder streams 2Studying rivers for clues to global carbon cycle 2Studying rivers for clues to global carbon cycle 3