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Nektar's PEGylation Technology Enables Peptide Mimetic, Highlighted by Data Presented at 45th ERA-EDTA Congress
Date:5/12/2008

SAN CARLOS, Calif., May 12 /PRNewswire-FirstCall/ -- Nektar Therapeutics (Nasdaq: NKTR) highlighted today that its proprietary PEGylation technology is used in the novel therapeutic, Hematide(TM), a synthetic, peptide-based erythropoiesis-stimulating agent that is under development by Takeda Global Research & Development Center, Inc. and Affymax. Data were presented for Hematide(TM) today at the 45th ERA-EDTA Congress in Stockholm, Sweden, which showed that Hematide(TM) administered once every four weeks was well-tolerated and maintained mean hemoglobin levels between 11 and 12 g/dL in patients with CKD, both pre-dialysis and hemodialysis, over a 12-month period.(1)

"The data on Hematide(TM) demonstrate how Nektar's advanced PEGylation chemistry can be used in peptide mimetics to enable a once-monthly dosing schedule while maintaining efficacy," said Tim Riley, Vice President of PEGylation Research at Nektar. "This represents another example of the unique value and broad applicability of Nektar's PEGylation technology and its ability to enable new therapeutics that otherwise might not be possible."

Under the terms of an exclusive agreement between Nektar and Affymax, Nektar is entitled to receive royalties on the global sales of Hematide(TM) for all indications, as well as manufacturing revenues.

With the use of Nektar's advanced PEGylation technology, the properties of therapeutic agents, such as Hematide(TM), can be enhanced by increasing drug circulation time in the bloodstream, decreasing immunogenicity, and reducing dosing frequency. Nektar proprietary technology uses advanced conjugation chemistry and techniques to attach polyethylene glycol polymers to therapeutic agents.

About Hematide(TM)

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SOURCE Nektar Therapeutics
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